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Volume 129, Issue 5

November 2018

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In this Issue

Table of Contents
Editorial Board
This Month in Anesthesiology
Science, Medicine, and the Anesthesiologist
Infographics in Anesthesiology
Anesthesiology CME Program
Editorial
Special Articles
Perioperative Medicine: Clinical Science
Perioperative Medicine: Basic Science
Pain Medicine: Clinical Science
Education: Images in Anesthesiology
Education: Review Article
Education: Mind to Mind
Correspondence
Reviews of Educational Material
Anesthesiology Reflections from the Wood Library-Museum
Erratum

Anesthesiology

Anesthesiology November 2018, Vol. 129, A3–A7. https://doi.org/10.1097/ALN.0000000000002489

View Articletitled, Anesthesiology

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Editorial Board

Anesthesiology

Anesthesiology November 2018, Vol. 129, A9–A10. https://doi.org/10.1097/ALN.0000000000002472

View Articletitled, Anesthesiology

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This Month in Anesthesiology

Anesthesiology November 2018, Vol. 129, A1–A2. https://doi.org/10.1097/ALN.0000000000002474

View Articletitled, This Month in Anesthesiology

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Science, Medicine, and the Anesthesiologist

Anesthesiology November 2018, Vol. 129, A13–A16. https://doi.org/10.1097/ALN.0000000000002478

View Articletitled, Science, Medicine, and the Anesthesiologist

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Infographics in Anesthesiology

A Calculated Risk: Comparing Perioperative Assessment Tools

Jonathan P. Wanderer; James P. Rathmell

Anesthesiology November 2018, Vol. 129, A17. https://doi.org/10.1097/ALN.0000000000002479

View Articletitled, A Calculated Risk: Comparing Perioperative Assessment Tools

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Topics: assessment scales

Anesthesiology CME Program

Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit

Anesthesiology November 2018, Vol. 129, A11. https://doi.org/10.1097/ALN.0000000000002456

View Articletitled, Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit

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Editorial

Postoperative Brain Function: Toward a Better Understanding and the American Society of Anesthesiologists Perioperative Brain Health Initiative

Daniel J. Cole, M.D.; Evan D. Kharasch, M.D., Ph.D.

Anesthesiology November 2018, Vol. 129, 861–863. https://doi.org/10.1097/ALN.0000000000002085

View Articletitled, Postoperative Brain Function: Toward a Better Understanding and the American Society of Anesthesiologists Perioperative Brain Health Initiative

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Topics: brain , brain function

Workflow Eats Optimum Care for Lunch

Warren S. Sandberg, M.D., Ph.D.; Sorin J. Brull, M.D., F.C.A.R.C.S.I.(Hon)

Anesthesiology November 2018, Vol. 129, 864–866. https://doi.org/10.1097/ALN.0000000000002437

View Articletitled, Workflow Eats Optimum Care for Lunch

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Topics: workflow

Preoperative Cardiac Evaluation before Noncardiac Surgery: Reverend Bayes’s Risk Indices and Optimal Variables

Lee A. Fleisher, M.D.

Anesthesiology November 2018, Vol. 129, 867–868. https://doi.org/10.1097/ALN.0000000000002422

View Articletitled, Preoperative Cardiac Evaluation before Noncardiac Surgery: Reverend Bayes’s Risk Indices and Optimal Variables

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Topics: preoperative cardiovascular examination , surgical procedures, operative

Highways of the Brain, Traffic of the Mind

George A. Mashour, M.D., Ph.D.

Anesthesiology November 2018, Vol. 129, 869–871. https://doi.org/10.1097/ALN.0000000000002385

View Articletitled, Highways of the Brain, Traffic of the Mind

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Topics: brain

Special Articles

Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery—2018

L. Evered; B. Silbert; D. S. Knopman; D. A. Scott; S. T. DeKosky; L. S. Rasmussen; E. S. Oh; G. Crosby; M. Berger; R. G. Eckenhoff; The Nomenclature Consensus Working Group

Anesthesiology November 2018, Vol. 129, 872–879. https://doi.org/10.1097/ALN.0000000000002334

View Articletitled, Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery—2018

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Topics: diagnostic and statistical manual , postoperative cognitive dysfunction , surgery specialty , surgical procedures, operative , cognitive impairment

Perioperative Medicine: Clinical Science

Comparison of the TOFscan and the TOF-Watch SX during Recovery of Neuromuscular Function

Glenn S. Murphy, M.D.; Joseph W. Szokol, M.D.; Michael J. Avram, Ph.D.; Steven B. Greenberg, M.D.; Torin D. Shear, M.D.; Mark Deshur, M.D.; Jessica Benson, B.S.; Rebecca L. Newmark, B.A.; Colleen E. Maher, B.S.

Anesthesiology November 2018, Vol. 129, 880–888. https://doi.org/10.1097/ALN.0000000000002400

View Articletitled, Comparison of the TOFscan and the TOF-Watch SX during Recovery of Neuromuscular Function

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Topics: neuromuscular function , signs and symptoms , induction of neuromuscular blockade , neuromuscular blockade monitoring

Impact of the Choice of Risk Model for Identifying Low-risk Patients Using the 2014 American College of Cardiology/American Heart Association Perioperative Guidelines

Laurent G. Glance, M.D.; Eric Faden, M.D.; Richard P. Dutton, M.D., M.B.A.; Stewart J. Lustik, M.D., M.B.A.; Yue Li, Ph.D.; Michael P. Eaton, M.D.; Andrew W. Dick, Ph.D.

Anesthesiology November 2018, Vol. 129, 889–900. https://doi.org/10.1097/ALN.0000000000002341

View Articletitled, Impact of the Choice of Risk Model for Identifying Low-risk Patients Using the 2014 American College of Cardiology/American Heart Association Perioperative Guidelines

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Topics: american college of cardiology , american college of surgeons , american heart association , cardiac arrest , cardiac event

Differences of Recovery from Rocuronium-induced Deep Paralysis in Response to Small Doses of Sugammadex between Elderly and Nonelderly Patients

Takahiro Muramatsu, M.D.; Shiroh Isono, M.D.; Teruhiko Ishikawa, M.D.; Natsuko Nozaki-Taguchi, M.D.; Junko Okazaki, M.D.; Yuji Kitamura, M.D.; Noriko Murakami, M.D.; Yasunori Sato, Ph.D.

Anesthesiology November 2018, Vol. 129, 901–911. https://doi.org/10.1097/ALN.0000000000002412

View Articletitled, Differences of Recovery from Rocuronium-induced Deep Paralysis in Response to Small Doses of Sugammadex between Elderly and Nonelderly Patients

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Topics: older adult , rocuronium , sugammadex , train-of-four monitoring , paralysis

Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans: A Randomized, Double-blind, Crossover Study

Robert Fong, M.D., Ph.D.; Lingzhi Wang, M.D.; James P. Zacny, Ph.D.; Suhail Khokhar, M.P.H.; Jeffrey L. Apfelbaum, M.D.; Aaron P. Fox, Ph.D.; Zheng Xie, M.D., Ph.D.

Anesthesiology November 2018, Vol. 129, 912–920. https://doi.org/10.1097/ALN.0000000000002367

View Articletitled, Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans: A Randomized, Double-blind, Crossover Study

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Topics: caffeine , isoflurane , saline solutions

Effect of Equipotent Doses of Propofol versus Sevoflurane Anesthesia on Regulatory T Cells after Breast Cancer Surgery

Chung-Sik Oh, M.D., Ph.D.; Jaemoon Lee, M.D.; Tae-Gyoon Yoon, M.D., Ph.D.; Eun-Hye Seo, Ph.D.; Hyun-Jun Park, B.S.; Liyun Piao, B.S.; Seung-Hyun Lee, M.D., Ph.D.; Seong-Hyop Kim, M.D., Ph.D.

Anesthesiology November 2018, Vol. 129, 921–931. https://doi.org/10.1097/ALN.0000000000002382

View Articletitled, Effect of Equipotent Doses of Propofol versus Sevoflurane Anesthesia on Regulatory T Cells after Breast Cancer Surgery

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Topics: clusters of differentiation , operative management of breast cancer , propofol , regulatory t-lymphocytes , sevoflurane

Propofol-based Total Intravenous Anesthesia Is Associated with Better Survival Than Desflurane Anesthesia in Colon Cancer Surgery

Zhi-Fu Wu, M.D.; Meei-Shyuan Lee, D.P.H.; Chih-Shung Wong, M.D., Ph.D.; Chueng-He Lu, M.D.; Yuan-Shiou Huang, M.D.; Kuen-Tze Lin, M.D.; Yu-Sheng Lou, M.S.; Chin Lin, Ph.D.; Yue-Cune Chang, Ph.D.; Hou-Chuan Lai, M.D.

Anesthesiology November 2018, Vol. 129, 932–941. https://doi.org/10.1097/ALN.0000000000002357

View Articletitled, Propofol-based Total Intravenous Anesthesia Is Associated with Better Survival Than Desflurane Anesthesia in Colon Cancer Surgery

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Topics: colon cancer , colorectal cancer , desflurane , propofol , surgical procedures, operative

Perioperative Medicine: Basic Science

Resting-state Dynamics as a Cortical Signature of Anesthesia in Monkeys

Lynn Uhrig, M.D., Ph.D.; Jacobo D. Sitt, M.D., Ph.D.; Amaury Jacob, M.Sc.; Jordy Tasserie, M.Sc.; Pablo Barttfeld, Ph.D.; Morgan Dupont, M.Sc.; Stanislas Dehaene, Ph.D.; Bechir Jarraya, M.D., Ph.D.

Anesthesiology November 2018, Vol. 129, 942–958. https://doi.org/10.1097/ALN.0000000000002336

View Articletitled, Resting-state Dynamics as a Cortical Signature of Anesthesia in Monkeys

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Topics: brain , cercopithecidae , functional magnetic resonance imaging , ketamine , propofol

Etomidate and Etomidate Analog Binding and Positive Modulation of γ-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect

Megan McGrath, B.S.; Zhiyi Yu, Ph.D.; Selwyn S. Jayakar, Ph.D.; Celena Ma, B.S.; Mansi Tolia, M.S.; Xiaojuan Zhou, Ph.D.; Keith W. Miller, D.Phil.; Jonathan B. Cohen, Ph.D.; Douglas E. Raines, M.D.

Anesthesiology November 2018, Vol. 129, 959–969. https://doi.org/10.1097/ALN.0000000000002356

View Articletitled, Etomidate and Etomidate Analog Binding and Positive Modulation of γ-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect

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Topics: etomidate , gaba-a receptor , gamma-aminobutyric acid

Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine

John J. Savarese, M.D.; Hiroshi Sunaga, M.D.; Jeff D. McGilvra, Ph.D.; Matthew R. Belmont, M.D.; Matthew T. Murrell, M.D., Ph.D.; Erin Jeannotte, L.V.T., R.Lat.G.; Farrell E. Cooke, B.S.; William B. Wastila, Ph.D.; Paul M. Heerdt, M.D., Ph.D.

Anesthesiology November 2018, Vol. 129, 970–988. https://doi.org/10.1097/ALN.0000000000002408

View Articletitled, Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine

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Topics: cysteine , gantacurium , induction of neuromuscular blockade , neuromuscular blockade monitoring , neuromuscular blocking agents

Ultrasound Elastography for Rapid, Real-time Detection of Localized Muscular Reaction in Malignant Hyperthermia–susceptible Pigs

Stephan Johannsen, M.D.; Ismail Türkmeneli, M.D.; Susanne Isbary, M.D.; Norbert Roewer, M.D.; Frank Schuster, M.D.

Anesthesiology November 2018, Vol. 129, 989–999. https://doi.org/10.1097/ALN.0000000000002424

View Articletitled, Ultrasound Elastography for Rapid, Real-time Detection of Localized Muscular Reaction in Malignant Hyperthermia–susceptible Pigs

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Topics: caffeine , elasticity imaging techniques , halothane , malignant hyperthermia due to anesthesia , suidae

Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo

Chunyan Wang, M.D., Ph.D.; Tanweer Datoo, M.Res., B.Sc.; Hailin Zhao, Ph.D.; Lingzhi Wu, M.Res., B.Sc.; Akshay Date, M.B.B.S.; Cui Jiang, M.Res., B.Sc.; Robert D. Sanders, M.B.B.S., Ph.D., F.R.C.A.; Guolin Wang, M.D., Ph.D.; Charlotte Bevan, Ph.D.; Daqing Ma, M.D., Ph.D., F.R.C.A.

Anesthesiology November 2018, Vol. 129, 1000–1014. https://doi.org/10.1097/ALN.0000000000002401

View Articletitled, Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo

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Topics: dexmedetomidine , midazolam , carcinoma of lung

Pain Medicine: Clinical Science

Brain Dynamics and Temporal Summation of Pain Predicts Neuropathic Pain Relief from Ketamine Infusion

Rachael L. Bosma, Ph.D.; Joshua C. Cheng, Ph.D.; Anton Rogachov, B.Sc.; Junseok A. Kim, M.Sc.; Kasey S. Hemington, Ph.D.; Natalie R. Osborne, M.Sc.; Lakshmikumar Venkat Raghavan, M.D.; Anuj Bhatia, M.D.; Karen D. Davis, Ph.D.

Anesthesiology November 2018, Vol. 129, 1015–1024. https://doi.org/10.1097/ALN.0000000000002417

View Articletitled, Brain Dynamics and Temporal Summation of Pain Predicts Neuropathic Pain Relief from Ketamine Infusion

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Topics: brain , infusion procedures , ketamine , neuropathic pain , pain

Education: Images in Anesthesiology

Images in Anesthesiology: Early Identification of Tamponade Using Focused Cardiac Ultrasound

Matthew Sigakis, M.D.; Babar Fiza, M.D.

Anesthesiology November 2018, Vol. 129, 1025. https://doi.org/10.1097/ALN.0000000000002283

View Articletitled, Images in Anesthesiology: Early Identification of Tamponade Using Focused Cardiac Ultrasound

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Topics: early diagnosis , echocardiography

Unstable Cervical Spine Fracture Triggered by a Congenital Neurodegenerative Disorder

Ricardo Diaz Milian, M.D.; Manuel R. Castresana, M.D., F.C.C.M., F.A.S.A.

Anesthesiology November 2018, Vol. 129, 1026. https://doi.org/10.1097/ALN.0000000000002282

View Articletitled, Unstable Cervical Spine Fracture Triggered by a Congenital Neurodegenerative Disorder

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Topics: cervical spine instability , fractures , neurodegenerative disorders

Extreme Trachea Dilatation after Prolonged Ventilation at High Tracheal Cuff Pressure

YuLiang Miao, M.D.; Yan Liu, M.D.; RuiJuan Wang, M.D.; Jing Wang, M.D.

Anesthesiology November 2018, Vol. 129, 1027. https://doi.org/10.1097/ALN.0000000000002370

View Articletitled, Extreme Trachea Dilatation after Prolonged Ventilation at High Tracheal Cuff Pressure

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Topics: dilatation, pathologic , environmental air flow , respiration , trachea

False-positive Transesophageal Echocardiography after False-positive Computed Tomography Angiography in Suspected Type A Aortic Dissection

Edward Gologorsky, M.D., F.A.S.E.; Qin N. Zhang, M.D.; Angela Gologorsky, M.D.

Anesthesiology November 2018, Vol. 129, 1028. https://doi.org/10.1097/ALN.0000000000002347

View Articletitled, False-positive Transesophageal Echocardiography after False-positive Computed Tomography Angiography in Suspected Type A Aortic Dissection

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Topics: computed tomographic angiography , false-positive results , proximal aortic dissection , transesophageal echocardiography

Education: Review Article

Role of Network Science in the Study of Anesthetic State Transitions

UnCheol Lee, Ph.D.; George A. Mashour, M.D., Ph.D.

Anesthesiology November 2018, Vol. 129, 1029–1044. https://doi.org/10.1097/ALN.0000000000002228

View Articletitled, Role of Network Science in the Study of Anesthetic State Transitions

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Topics: anesthesia, general , brain , unconsciousness , consciousness related finding

Education: Mind to Mind

To My Mother in Surgery
Part of the Letheon Writing Competition

Karen Paul Holmes

Anesthesiology November 2018, Vol. 129, 1045. https://doi.org/10.1097/ALN.0000000000002263

View Articletitled, To My Mother in Surgery

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Topics: mothers , surgery specialty , surgical procedures, operative

Acceptance: A Letter to My Grieving Self

Katherine B. Hagan, M.D.

Anesthesiology November 2018, Vol. 129, 1046–1047. https://doi.org/10.1097/ALN.0000000000002345

View Articletitled, Acceptance: A Letter to My Grieving Self

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Topics: bereavement , grief

Correspondence

Surrogates or Outcomes: What Should We Measure?

Mark C. Kendall, M.D.

Anesthesiology November 2018, Vol. 129, 1048. https://doi.org/10.1097/ALN.0000000000002418

View Articletitled, Surrogates or Outcomes: What Should We Measure?

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In Reply

Lukas M. Löffel, M.D.; Marc P. Schneider, M.D., Ph.D.; Stefan A. Girsberger, M.D.; Fiona C. Burkhard, M.D.; Patrick Y. Wuethrich, M.D.

Anesthesiology November 2018, Vol. 129, 1048–1049. https://doi.org/10.1097/ALN.0000000000002419

View Articletitled, In Reply

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Airway Management: The Less Popular Skill of Bag-mask Ventilation

Gerald P. Rosen, M.D.; Omar Viswanath, M.D.; Jason C. Wigley, M.D.; Bryan Kerner, D.O.

Anesthesiology November 2018, Vol. 129, 1049–1050. https://doi.org/10.1097/ALN.0000000000002420

View Articletitled, Airway Management: The Less Popular Skill of Bag-mask Ventilation

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In Reply

Rebecca A. Schroeder, M.D.; Richard Pollard, M.D.; Mark Stafford-Smith, M.D., C.M., F.R.C.P.C.

Anesthesiology November 2018, Vol. 129, 1050–1051. https://doi.org/10.1097/ALN.0000000000002421

View Articletitled, In Reply

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Reviews of Educational Material

Anesthesia: The Gift of Oblivion and the Mystery of Consciousness.

J. Lance Lichtor, M.D.

Anesthesiology November 2018, Vol. 129, 1052. https://doi.org/10.1097/ALN.0000000000002369

View Articletitled, Anesthesia: The Gift of Oblivion and the Mystery of Consciousness.

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Topics: consciousness related finding

Anesthesiology Reflections from the Wood Library-Museum

The Trademarked Red “Elixir of Life,” Hall’s Coca Wine

Anesthesiology November 2018, Vol. 129, 863. https://doi.org/10.1097/ALN.0000000000002464

View Articletitled, The Trademarked Red “Elixir of Life,” Hall’s Coca Wine

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How Hertzler’s Local Anesthesia Saw More Than Local Military Action

Anesthesiology November 2018, Vol. 129, 871. https://doi.org/10.1097/ALN.0000000000002465

View Articletitled, How Hertzler’s Local Anesthesia Saw More Than Local Military Action

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Not a Pipe Dream: Crescent Interest in Free’s Vegetable Anesthetic

Anesthesiology November 2018, Vol. 129, 941. https://doi.org/10.1097/ALN.0000000000002466

View Articletitled, Not a Pipe Dream: Crescent Interest in Free’s Vegetable Anesthetic

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As for “Fresh Laughing Gas”—Get It Out of Jehl Free....

Anesthesiology November 2018, Vol. 129, 958. https://doi.org/10.1097/ALN.0000000000002467

View Articletitled, As for “Fresh Laughing Gas”—Get It Out of Jehl Free....

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Crying Foul on Chloroforming Fowl

Anesthesiology November 2018, Vol. 129, 1014. https://doi.org/10.1097/ALN.0000000000002468

View Articletitled, Crying Foul on Chloroforming Fowl

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Erratum

Perioperative Hyperglycemia Management: An Update: Erratum

Anesthesiology November 2018, Vol. 129, 1053. https://doi.org/10.1097/ALN.0000000000002425

View Articletitled, Perioperative Hyperglycemia Management: An Update: Erratum

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Issues

Cover Image

Table of Contents

Editorial Board

This Month in Anesthesiology

Science, Medicine, and the Anesthesiologist

Infographics in Anesthesiology

Anesthesiology CME Program

Editorial

Special Articles

Perioperative Medicine: Clinical Science

Perioperative Medicine: Basic Science

Pain Medicine: Clinical Science

Education: Images in Anesthesiology

Education: Review Article

Education: Mind to Mind

To My Mother in Surgery Part of the Letheon Writing Competition

Correspondence

Reviews of Educational Material

Anesthesiology Reflections from the Wood Library-Museum

Erratum

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To My Mother in Surgery
Part of the Letheon Writing Competition