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Volume 135, Issue 2

August 2021

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In this Issue

Table of Contents
Editorial Board
This Month in Anesthesiology
Science, Medicine, and the Anesthesiologist
Infographics in Anesthesiology
Anesthesiology CME Program
Editorial
Perioperative Medicine: Clinical Science
Critical Care Medicine: Clinical Science
Pain Medicine: Clinical Science
Education: Images in Anesthesiology
Education: Clinical Focus Review
Education: Review Article
Education: Mind to Mind
Anesthesiology Reflections from the Wood Library-Museum
Correspondence
Erratum

Anesthesiology

Anesthesiology August 2021, Vol. 135, A3–A5. https://doi.org/10.1097/ALN.0000000000003915

View Articletitled, Anesthesiology

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Editorial Board

Anesthesiology

Anesthesiology August 2021, Vol. 135, A9–A11. https://doi.org/10.1097/ALN.0000000000003889

View Articletitled, Anesthesiology

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This Month in Anesthesiology

Anesthesiology August 2021, Vol. 135, A1–A2. https://doi.org/10.1097/ALN.0000000000003888

View Articletitled, This Month in Anesthesiology

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Science, Medicine, and the Anesthesiologist

Anesthesiology August 2021, Vol. 135, A15–A18. https://doi.org/10.1097/ALN.0000000000003891

View Articletitled, Science, Medicine, and the Anesthesiologist

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Infographics in Anesthesiology

Putting the Neuro in Neuraxial: Delirium Reduction and Epidurals

Jonathan P. Wanderer; James P. Rathmell

Anesthesiology August 2021, Vol. 135, A19. https://doi.org/10.1097/ALN.0000000000003892

View Articletitled, Putting the Neuro in Neuraxial: Delirium Reduction and Epidurals

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Topics: delirium

Anesthesiology CME Program

Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit
CME Article

Anesthesiology August 2021, Vol. 135, A13. https://doi.org/10.1097/ALN.0000000000003890

View Articletitled, Instructions for Obtaining A<span class="small-caps">nesthesiology</span> Continuing Medical Education (CME) Credit

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Editorial

The Cognitive Neuraxis: Epidurals and Postoperative Delirium

Phillip E. Vlisides, M.D.; George A. Mashour, M.D., Ph.D.

Anesthesiology August 2021, Vol. 135, 197–199. https://doi.org/10.1097/ALN.0000000000003824

View Articletitled, The Cognitive Neuraxis: Epidurals and Postoperative Delirium

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Topics: axon , postoperative delirium , delirium

A Step toward Combined Platelet and Erythrocyte Recovery

David Faraoni, M.D., Ph.D.; Ian J. Welsby, B.Sc., M.B.B.S.

Anesthesiology August 2021, Vol. 135, 200–202. https://doi.org/10.1097/ALN.0000000000003846

View Articletitled, A Step toward Combined Platelet and Erythrocyte Recovery

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Topics: blood platelets , erythrocytes

Computer-assisted Anesthesia Care: Avoiding the Highway to HAL

David A. Story, M.D., F.A.N.Z.C.A.

Anesthesiology August 2021, Vol. 135, 203–205. https://doi.org/10.1097/ALN.0000000000003838

View Articletitled, Computer-assisted Anesthesia Care: Avoiding the Highway to HAL

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Topics: anesthesia care , computers

Back to the OR of the Future: How Do We Make It a Good One?

Martin J. London, M.D., F.A.S.E.

Anesthesiology August 2021, Vol. 135, 206–208. https://doi.org/10.1097/ALN.0000000000003862

View Articletitled, Back to the OR of the Future: How Do We Make It a Good One?

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Topics: artificial intelligence , intraoperative care , operating room , perioperative care , software

Pulmonary Aspiration of Gastric Contents: Can We Improve Patient Outcomes?

Anahi Perlas, M.D., F.R.C.P.C.; Cristian Arzola, M.D., M.Sc.

Anesthesiology August 2021, Vol. 135, 209–211. https://doi.org/10.1097/ALN.0000000000003861

View Articletitled, Pulmonary Aspiration of Gastric Contents: Can We Improve Patient Outcomes?

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Topics: patient-focused outcomes , pulmonary aspiration of gastric contents

Emergency Airway Management in the Time of COVID-19: Lessons for All?

Tim M. Cook, M.B.B.S.

Anesthesiology August 2021, Vol. 135, 212–214. https://doi.org/10.1097/ALN.0000000000003819

View Articletitled, Emergency Airway Management in the Time of COVID-19: Lessons for All?

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Topics: airway maintenance , covid-19

Chronic Postoperative Pain: Preventable or Inevitable?

J. David Clark, M.D., Ph.D.

Anesthesiology August 2021, Vol. 135, 215–217. https://doi.org/10.1097/ALN.0000000000003839

View Articletitled, Chronic Postoperative Pain: Preventable or Inevitable?

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Topics: postoperative pain , pain

Perioperative Medicine: Clinical Science

Delirium in Older Patients after Combined Epidural–General Anesthesia or General Anesthesia for Major Surgery: A Randomized Trial
This article has a Visual Abstract This article has an Audio Podcast

Ya-Wei Li, M.D.; Huai-Jin Li, M.D.; Hui-Juan Li, Ph.D.; Bin-Jiang Zhao, M.D.; Xiang-Yang Guo, M.D.; Yi Feng, M.D.; Ming-Zhang Zuo, M.D.; Yong-Pei Yu, Ph.D.; Hao Kong, M.D.; Yi Zhao, M.D.; Da Huang, M.D.; Chun-Mei Deng, M.D.; Xiao-Yun Hu, M.D.; Peng-Fei Liu, M.D.; Yan Li, M.D.; Hai-Yan An, M.D.; Hong-Ye Zhang, M.D.; Mei-Rong Wang, M.D.; Yang-Feng Wu, M.D., Ph.D.; Dong-Xin Wang, M.D., Ph.D.; Daniel I. Sessler, M.D.; for the Peking University Clinical Research Program Study Group

Anesthesiology August 2021, Vol. 135, 218–232. https://doi.org/10.1097/ALN.0000000000003834

View Articletitled, Delirium in Older Patients after Combined Epidural–General Anesthesia or General Anesthesia for Major Surgery: A Randomized Trial

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Topics: anesthesia, general , delirium , older adult , surgical procedures, operative , surgery specialty

Long-term Survival after Combined Epidural–General Anesthesia or General Anesthesia Alone: Follow-up of a Randomized Trial
This article has a Visual Abstract

Ya-Ting Du, M.D.; Ya-Wei Li, M.D.; Bin-Jiang Zhao, M.D.; Xiang-Yang Guo, M.D.; Yi Feng, M.D.; Ming-Zhang Zuo, M.D.; Cong Fu, M.D.; Wei-Jie Zhou, M.D.; Huai-Jin Li, M.D.; Ya-Fei Liu, M.D.; Tong Cheng, M.D.; Dong-Liang Mu, M.D.; Yuan Zeng, M.D.; Peng-Fei Liu, M.D.; Yan Li, M.D.; Hai-Yan An, M.D.; Sai-Nan Zhu, M.S.; Xue-Ying Li, M.S.; Hui-Juan Li, Ph.D.; Yang-Feng Wu, M.D., Ph.D.; Dong-Xin Wang, M.D., Ph.D.; Daniel I. Sessler, M.D.; for the Peking University Clinical Research Program Study Group

Anesthesiology August 2021, Vol. 135, 233–245. https://doi.org/10.1097/ALN.0000000000003835

View Articletitled, Long-term Survival after Combined Epidural–General Anesthesia or General Anesthesia Alone: Follow-up of a Randomized Trial

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Topics: anesthesia, general , cancer , follow-up , surgical procedures, operative , surgery specialty

Combined Platelet and Erythrocyte Salvage: Evaluation of a New Filtration-based Autotransfusion Device
This article has a Visual Abstract

Alexandre Mansour, M.D.; Benoit Decouture, Ph.D.; Mikaël Roussel, M.D., Ph.D.; Charles Lefevre, Pharm.D.; Lucie Skreko, M.Sc.; Véronique Picard, M.D.; Alexandre Ouattara, M.D., Ph.D.; Christilla Bachelot-Loza, Ph.D.; Pascale Gaussem, Pharm.D., Ph.D.; Nicolas Nesseler, M.D., Ph.D.; Isabelle Gouin-Thibault, Pharm.D., Ph.D.

Anesthesiology August 2021, Vol. 135, 246–257. https://doi.org/10.1097/ALN.0000000000003820

View Articletitled, Combined Platelet and Erythrocyte Salvage: Evaluation of a New Filtration-based Autotransfusion Device

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Topics: autologous blood transfusion , blood platelets , erythrocytes , filtration , medical devices

Computer-assisted Individualized Hemodynamic Management Reduces Intraoperative Hypotension in Intermediate- and High-risk Surgery: A Randomized Controlled Trial
This article has a Visual Abstract This article has a Video Abstract

Alexandre Joosten, M.D., Ph.D.; Joseph Rinehart, M.D.; Philippe Van der Linden, M.D., Ph.D.; Brenton Alexander, M.D.; Christophe Penna, M.D., Ph.D.; Jacques De Montblanc, M.D.; Maxime Cannesson, M.D., Ph.D.; Jean-Louis Vincent, M.D., Ph.D.; Eric Vicaut, M.D., Ph.D.; Jacques Duranteau, M.D., Ph.D.

Anesthesiology August 2021, Vol. 135, 258–272. https://doi.org/10.1097/ALN.0000000000003807

View Articletitled, Computer-assisted Individualized Hemodynamic Management Reduces Intraoperative Hypotension in Intermediate- and High-risk Surgery: A Randomized Controlled Trial

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Topics: computers , hemodynamics , intraoperative hypotension , surgical procedures, operative , doppler hemodynamics

Assisted Fluid Management Software Guidance for Intraoperative Fluid Administration
This article has a Visual Abstract

Kamal Maheshwari, M.D., M.P.H.; Gaurav Malhotra, M.D.; Xiaodong Bao, M.D., Ph.D.; Peiman Lahsaei, M.D.; William R. Hand, M.D.; Neal W. Fleming, M.D., Ph.D.; Davinder Ramsingh, M.D.; Miriam M. Treggiari, M.D., Ph.D., M.P.H.; Daniel I. Sessler, M.D.; Timothy E. Miller, M.B.Ch.B.; on behalf of the Assisted Fluid Management Study Team

Anesthesiology August 2021, Vol. 135, 273–283. https://doi.org/10.1097/ALN.0000000000003790

View Articletitled, Assisted Fluid Management Software Guidance for Intraoperative Fluid Administration

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Topics: fluid management , intraoperative care , intravenous fluids administration , software

Pulmonary Aspiration of Gastric Contents: A Closed Claims Analysis
This article has a Visual Abstract This article has an Audio Podcast

Mark A. Warner, M.D.; Karen L. Meyerhoff, M.D., M.P.H.; Mary E. Warner, M.D.; Karen L. Posner, Ph.D.; Linda Stephens, Ph.D.; Karen B. Domino, M.D., M.P.H.

Anesthesiology August 2021, Vol. 135, 284–291. https://doi.org/10.1097/ALN.0000000000003831

View Articletitled, Pulmonary Aspiration of Gastric Contents: A Closed Claims Analysis

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Topics: insurance claim review , pulmonary aspiration , pulmonary aspiration of gastric contents , gastrointestinal obstruction

Critical Care Medicine: Clinical Science

Emergency Airway Management in Patients with COVID-19: A Prospective International Multicenter Cohort Study
This article has a Visual Abstract

Danny J. N. Wong, F.R.C.A., Ph.D.; Kariem El-Boghdadly, F.R.C.A., M.Sc.; Ruth Owen, M.Sc.; Craig Johnstone, F.R.C.A.; Mark D. Neuman, M.D., M.Sc.; Paweł Andruszkiewicz, Ph.D.; Paul A. Baker, M.D., F.A.N.Z.C.A.; Bruce M. Biccard, Ph.D.; Gregory L. Bryson, M.D., F.R.C.P.C., M.Sc.; Matthew T. V. Chan, M.B.B.S., Ph.D.; Ming Hua Cheng, M.Med.; Ki Jinn Chin, F.R.C.P.C.; Mark Coburn, M.D.; Malin Jonsson Fagerlund, M.D., Ph.D.; Clara A. Lobo, M.D.; Eugenio Martinez-Hurtado, M.D.; Sheila N. Myatra, M.D.; Paul S. Myles, D.Sc.; Guillermo Navarro, M.D.; Ellen O’Sullivan, F.R.C.A., F.C.A.I.; Laura Pasin, M.D.; Kathleen Quintero, M.D.; Nabil Shallik, M.D.; Faisal Shamim, F.C.P.S.; Wilton A. van Klei, M.D., Ph.D.; Imran Ahmad, F.R.C.A.

Anesthesiology August 2021, Vol. 135, 292–303. https://doi.org/10.1097/ALN.0000000000003791

View Articletitled, Emergency Airway Management in Patients with COVID-19: A Prospective International Multicenter Cohort Study

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Topics: airway maintenance , covid-19 , endotracheal intubation , income , intubation

Pain Medicine: Clinical Science

Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis
This article has a Visual Abstract

Meg E. Carley, B.Sc.; Luis E. Chaparro, M.D., F.R.C.P.C.; Manon Choinière, Ph.D.; Henrik Kehlet, M.D., Ph.D.; R. Andrew Moore, D.Sc.; Elizabeth Van Den Kerkhof, R.N., Dr.PH.; Ian Gilron, M.D., M.Sc.

Anesthesiology August 2021, Vol. 135, 304–325. https://doi.org/10.1097/ALN.0000000000003837

View Articletitled, Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis

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Topics: adult , chronic pain , pain , pharmacotherapy , prevention

Chiral Pharmacokinetics and Metabolite Profile of Prolonged-release Ketamine Tablets in Healthy Human Subjects
This article has a Visual Abstract

Mahmoud Hasan, Ph.D.; Christiane Modess, M.D.; Tarek Roustom, M.D.; Anne Dokter, M.D.; Markus Grube, Ph.D.; Andreas Link, Ph.D.; Hélène Rey, Ph.D.; Stefanie Adler, M.D.; Konrad Meissner, M.D.; Werner Siegmund, M.D.

Anesthesiology August 2021, Vol. 135, 326–339. https://doi.org/10.1097/ALN.0000000000003829

View Articletitled, Chiral Pharmacokinetics and Metabolite Profile of Prolonged-release Ketamine Tablets in Healthy Human Subjects

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Topics: ketamine , pharmacokinetics , tablet dosage form , metabolites , (2r,6r) hydroxynorketamine

Education: Images in Anesthesiology

Angiotensin-converting Enzyme Inhibitor–mediated Angioedema

Glenio B. Mizubuti, M.Sc., M.D.; Anthony M.-H. Ho, M.D., F.R.C.P.C., F.C.C.P.; Amy Jiang, M.D.; Gregory Klar, M.D., F.R.C.P.C.

Anesthesiology August 2021, Vol. 135, 340–341. https://doi.org/10.1097/ALN.0000000000003810

View Articletitled, Angiotensin-converting Enzyme Inhibitor–mediated Angioedema

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Topics: angioedema , angiotensin-converting enzyme inhibitors

Education: Clinical Focus Review

Viscoelastic Coagulation Testing: Use and Current Limitations in Perioperative Decision-making
CME Article

Gabor Erdoes, M.D., Ph.D.; Andreas Koster, M.D., Ph.D.; Jerrold H. Levy, M.D., F.C.C.M.

Anesthesiology August 2021, Vol. 135, 342–349. https://doi.org/10.1097/ALN.0000000000003814

View Articletitled, Viscoelastic Coagulation Testing: Use and Current Limitations in Perioperative Decision-making

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Topics: blood coagulation , coagulation process , decision making , fibrinogen , perioperative care

Education: Review Article

Evaluation of Therapies for Peripheral and Neuraxial Opioid-induced Pruritus based on Molecular and Cellular Discoveries

Eileen Nguyen, B.S.; Grace Lim, M.D., M.S.; Sarah E. Ross, Ph.D.

Anesthesiology August 2021, Vol. 135, 350–365. https://doi.org/10.1097/ALN.0000000000003844

View Articletitled, Evaluation of Therapies for Peripheral and Neuraxial Opioid-induced Pruritus based on Molecular and Cellular Discoveries

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Topics: opioid analgesics , opioids , pruritus

Education: Mind to Mind

The Path of Minimal Pain

Kate E. Lee, B.A.

Anesthesiology August 2021, Vol. 135, 366–367. https://doi.org/10.1097/ALN.0000000000003832

View Articletitled, The Path of Minimal Pain

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Topics: pain

Preanesthesia Anxiety

Amolpreet S. Toor, B.M.Sc.(Hons.)

Anesthesiology August 2021, Vol. 135, 368–369. https://doi.org/10.1097/ALN.0000000000003836

View Articletitled, Preanesthesia Anxiety

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Topics: anxiety , preanesthetic medication

Anesthesiology Reflections from the Wood Library-Museum

O’Dwyer’s Intubation Set Disrupts Diphtheria’s Dyspnea

Anesthesiology August 2021, Vol. 135, 245. https://doi.org/10.1097/ALN.0000000000003893

View Articletitled, O’Dwyer’s Intubation Set Disrupts Diphtheria’s Dyspnea

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Coca: The Sun God’s Anesthetic Leaves

Anesthesiology August 2021, Vol. 135, 291. https://doi.org/10.1097/ALN.0000000000003894

View Articletitled, Coca: The Sun God’s Anesthetic Leaves

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Mouth Props: Vulcanite Takes a Bite Out of Dental Anesthesia

Anesthesiology August 2021, Vol. 135, 325. https://doi.org/10.1097/ALN.0000000000003895

View Articletitled, Mouth Props: Vulcanite Takes a Bite Out of Dental Anesthesia

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Correspondence

Pulse Wave Analysis to Estimate Cardiac Output: Comment

Scott Hughey, M.D.; Jacob Cole, M.D.; Gregory Booth, M.D.

Anesthesiology August 2021, Vol. 135, 370–371. https://doi.org/10.1097/ALN.0000000000003813

View Articletitled, Pulse Wave Analysis to Estimate Cardiac Output: Comment

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High-fidelity Cuff to Measure Blood Pressure: Comment

Michael H. Dueck, M.D.

Anesthesiology August 2021, Vol. 135, 371–372. https://doi.org/10.1097/ALN.0000000000003818

View Articletitled, High-fidelity Cuff to Measure Blood Pressure: Comment

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High-fidelity Cuff to Measure Blood Pressure: Reply

Josef Briegel, M.D.; Ulrich J. Pfeiffer, M.D.

Anesthesiology August 2021, Vol. 135, 372–373. https://doi.org/10.1097/ALN.0000000000003817

View Articletitled, High-fidelity Cuff to Measure Blood Pressure: Reply

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Patient Anxiety Caused by the Cures Act

Rotem Naftalovich, M.D., M.B.A.; Andrew John Iskander, M.D.; Patrick Joseph Discepola, M.D.; Aaron Avraham Schweitzer, B.A.; Jean Daniel Eloy, M.D.

Anesthesiology August 2021, Vol. 135, 373–374. https://doi.org/10.1097/ALN.0000000000003847

View Articletitled, Patient Anxiety Caused by the Cures Act

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Erratum

Emergency Airway Management in Patients with COVID-19: A Prospective International Multicenter Cohort Study: Erratum

Anesthesiology August 2021, Vol. 135, 375. https://doi.org/10.1097/ALN.0000000000003854

View Articletitled, Emergency Airway Management in Patients with COVID-19: A Prospective International Multicenter Cohort Study: Erratum

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Issues

Cover Image

Anesthesiology

Table of Contents

Editorial Board

This Month in Anesthesiology

Science, Medicine, and the Anesthesiologist

Infographics in Anesthesiology

Anesthesiology CME Program

Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit CME Article

Editorial

Perioperative Medicine: Clinical Science

Delirium in Older Patients after Combined Epidural–General Anesthesia or General Anesthesia for Major Surgery: A Randomized Trial This article has a Visual Abstract This article has an Audio Podcast

Long-term Survival after Combined Epidural–General Anesthesia or General Anesthesia Alone: Follow-up of a Randomized Trial This article has a Visual Abstract

Combined Platelet and Erythrocyte Salvage: Evaluation of a New Filtration-based Autotransfusion Device This article has a Visual Abstract

Computer-assisted Individualized Hemodynamic Management Reduces Intraoperative Hypotension in Intermediate- and High-risk Surgery: A Randomized Controlled Trial This article has a Visual Abstract This article has a Video Abstract

Assisted Fluid Management Software Guidance for Intraoperative Fluid Administration This article has a Visual Abstract

Pulmonary Aspiration of Gastric Contents: A Closed Claims Analysis This article has a Visual Abstract This article has an Audio Podcast

Critical Care Medicine: Clinical Science

Emergency Airway Management in Patients with COVID-19: A Prospective International Multicenter Cohort Study This article has a Visual Abstract

Pain Medicine: Clinical Science

Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis This article has a Visual Abstract

Chiral Pharmacokinetics and Metabolite Profile of Prolonged-release Ketamine Tablets in Healthy Human Subjects This article has a Visual Abstract

Education: Images in Anesthesiology

Education: Clinical Focus Review

Viscoelastic Coagulation Testing: Use and Current Limitations in Perioperative Decision-making CME Article

Education: Review Article

Education: Mind to Mind

Anesthesiology Reflections from the Wood Library-Museum

Correspondence

Erratum

Email alerts

RSS

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Most Cited

Social Media

This Feature Is Available To Subscribers Only

Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit
CME Article

Delirium in Older Patients after Combined Epidural–General Anesthesia or General Anesthesia for Major Surgery: A Randomized Trial
This article has a Visual Abstract This article has an Audio Podcast

Long-term Survival after Combined Epidural–General Anesthesia or General Anesthesia Alone: Follow-up of a Randomized Trial
This article has a Visual Abstract

Combined Platelet and Erythrocyte Salvage: Evaluation of a New Filtration-based Autotransfusion Device
This article has a Visual Abstract

Computer-assisted Individualized Hemodynamic Management Reduces Intraoperative Hypotension in Intermediate- and High-risk Surgery: A Randomized Controlled Trial
This article has a Visual Abstract This article has a Video Abstract

Assisted Fluid Management Software Guidance for Intraoperative Fluid Administration
This article has a Visual Abstract

Pulmonary Aspiration of Gastric Contents: A Closed Claims Analysis
This article has a Visual Abstract This article has an Audio Podcast

Emergency Airway Management in Patients with COVID-19: A Prospective International Multicenter Cohort Study
This article has a Visual Abstract

Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis
This article has a Visual Abstract

Chiral Pharmacokinetics and Metabolite Profile of Prolonged-release Ketamine Tablets in Healthy Human Subjects
This article has a Visual Abstract

Viscoelastic Coagulation Testing: Use and Current Limitations in Perioperative Decision-making
CME Article