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Issues

Volume 137, Issue 2
August 2022
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Anesthesiology

Table of Contents

Anesthesiology
Anesthesiology August 2022, Vol. 137, A3–A5. https://doi.org/10.1097/ALN.0000000000004319
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Editorial Board

Anesthesiology
Anesthesiology August 2022, Vol. 137, A7–A9. https://doi.org/10.1097/ALN.0000000000004306
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This Month in Anesthesiology

This Month in Anesthesiology
Anesthesiology August 2022, Vol. 137, A1–A2. https://doi.org/10.1097/ALN.0000000000004303
View Articletitled, This Month in Anesthesiology
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Science, Medicine, and the Anesthesiologist

Science, Medicine, and the Anesthesiologist
Anesthesiology August 2022, Vol. 137, A13–A16. https://doi.org/10.1097/ALN.0000000000004304
View Articletitled, Science, Medicine, and the Anesthesiologist
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Infographics in Anesthesiology

The Early Days: Do Immediate Perioperative Opioid Prescribing Practices Affect Long-Term Opioid Utilization?
Holly B. Ende; James P. Rathmell; Jonathan P. Wanderer
Anesthesiology August 2022, Vol. 137, A17. https://doi.org/10.1097/ALN.0000000000004305
View Articletitled, The Early Days: Do Immediate Perioperative Opioid Prescribing Practices Affect Long-Term Opioid Utilization?
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Topics: opioid analgesics , opioids , perioperative care , prescribing behavior

Anesthesiology CME Program

Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit
Anesthesiology August 2022, Vol. 137, A11. https://doi.org/10.1097/ALN.0000000000004307
View Articletitled, Instructions for Obtaining A<span class="small-caps">nesthesiology</span> Continuing Medical Education (CME) Credit
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Editorial

Postoperative Opioid Prescribing: Finding the Balance
This article has an Audio Podcast
Daniel I. McIsaac, M.D., M.P.H., F.R.C.P.C.; Karim S. Ladha, M.D., M.Sc.
Anesthesiology August 2022, Vol. 137, 131–133. https://doi.org/10.1097/ALN.0000000000004297
View Articletitled, Postoperative Opioid Prescribing: Finding the Balance
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Topics: opioids , prescribing behavior
Realigning Incentives for Novel Pain Therapeutics
Michael S. Sinha, M.D., J.D., M.P.H.; Kelly K. Dineen Gillespie, R.N., J.D., Ph.D.
Anesthesiology August 2022, Vol. 137, 134–136. https://doi.org/10.1097/ALN.0000000000004287
View Articletitled, Realigning Incentives for Novel Pain Therapeutics
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Topics: incentives , pain

Readers' Toolbox

Understanding Research Methods: Up-and-down Designs for Dose-finding
Readers' Toolbox
Assaf P. Oron, Ph.D.; Michael J. Souter, M.B., Ch.B., F.R.C.A., F.N.C.S.; Nancy Flournoy, Ph.D.
Anesthesiology August 2022, Vol. 137, 137–150. https://doi.org/10.1097/ALN.0000000000004282
View Articletitled, Understanding Research Methods: Up-and-down Designs for Dose-finding
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Topics: median effective dose

Perioperative Medicine: Clinical Science

Surgeon Variation in Perioperative Opioid Prescribing and Medium- or Long-term Opioid Utilization after Total Knee Arthroplasty: A Cross-sectional Analysis
This article has an Audio Podcast
Xi Cen, Ph.D.; Anupam B. Jena, M.D., Ph.D.; Sean Mackey, M.D., Ph.D.; Eric C. Sun, M.D., Ph.D.
Anesthesiology August 2022, Vol. 137, 151–162. https://doi.org/10.1097/ALN.0000000000004259
View Articletitled, Surgeon Variation in Perioperative Opioid Prescribing and Medium- or Long-term Opioid Utilization after Total Knee Arthroplasty: A Cross-sectional Analysis
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Topics: knee replacement arthroplasty , opioid analgesics , opioids , perioperative care , prescribing behavior
Population Pharmacokinetics of Intranasal Dexmedetomidine in Infants and Young Children
Bi L. Li, M.D.; Yan P. Guan, M.D.; Vivian M. Yuen, M.D.; Wei Wei, M.D.; Min Huang, Ph.D.; Ma Z. Zhang, M.D.; Ai W. Li, Ph.D.; Joseph F. Standing, Ph.D.; Guo P. Zhong, Ph.D.; Xing R. Song, M.D.
Anesthesiology August 2022, Vol. 137, 163–175. https://doi.org/10.1097/ALN.0000000000004258
View Articletitled, Population Pharmacokinetics of Intranasal Dexmedetomidine in Infants and Young Children
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Topics: child , dexmedetomidine , pharmacokinetics , infant
Gas Phase Diffusion Does Not Limit Lung Volatile Anesthetic Uptake Rate
Philip J. Peyton, M.D., Ph.D., M.B.B.S., F.A.N.Z.C.A.
Anesthesiology August 2022, Vol. 137, 176–186. https://doi.org/10.1097/ALN.0000000000004260
View Articletitled, Gas Phase Diffusion Does Not Limit Lung Volatile Anesthetic Uptake Rate
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Topics: carbon dioxide , desflurane , diffusion , lung , partial pressure
Isoelectric Electroencephalography in Infants and Toddlers during Anesthesia for Surgery: An International Observational Study
This article has an Audio Podcast
Ian Yuan, M.D.; Ting Xu, M.D.; Justin Skowno, M.B.Ch.B., Ph.D.; Bingqing Zhang, M.P.H.; Andrew Davidson, M.B.B.S., M.D., Ph.D.; Britta S. von Ungern-Sternberg, M.D., Ph.D.; David Sommerfield, M.D.; Jianmin Zhang, M.D.; Xingrong Song, M.D., Ph.D.; Mazhong Zhang, M.D., Ph.D.; Ping Zhao, M.D., Ph.D.; Huacheng Liu, M.D., Ph.D.; Yifei Jiang, M.D., Ph.D.; Yunxia Zuo, M.D., Ph.D.; Jurgen C. de Graaff, M.D., Ph.D.; Laszlo Vutskits, M.D., Ph.D.; Vanessa A. Olbrecht, M.D., M.B.A.; Peter Szmuk, M.D.; Charles D. Kurth, M.D.; for the BRAIN Collaborative Investigators
Anesthesiology August 2022, Vol. 137, 187–200. https://doi.org/10.1097/ALN.0000000000004262
View Articletitled, Isoelectric Electroencephalography in Infants and Toddlers during Anesthesia for Surgery: An International Observational Study
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Topics: electroencephalography , infant , isoelectric electroencephalogram , propofol , sevoflurane
Expert Consensus Regarding Core Outcomes for Enhanced Recovery after Cesarean Delivery Studies: A Delphi Study
Pervez Sultan, M.B.Ch.B.; Ron George, M.D.; Carolyn F. Weiniger, M.D.; K. El-Boghdadly, M.B.B.S.; Perman Pandal, M.B.B.S.; Brendan Carvalho, M.B.B.Ch.; CRADLE Study Investigators
Anesthesiology August 2022, Vol. 137, 201–211. https://doi.org/10.1097/ALN.0000000000004263
View Articletitled, Expert Consensus Regarding Core Outcomes for Enhanced Recovery after Cesarean Delivery Studies: A Delphi Study
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Topics: cesarean section , consensus

Perioperative Medicine: Basic Science

Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice via Canonical NO-mediated Protein Kinase-G Signaling
Swati Agarwal, Ph.D.; Michele L. Schaefer, Ph.D.; Caroline Krall, B.V.M.&S., M.Sc.; Roger A. Johns, M.D., M.H.S., Ph.D.
Anesthesiology August 2022, Vol. 137, 212–231. https://doi.org/10.1097/ALN.0000000000004264
View Articletitled, Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice <em>via</em> Canonical NO-mediated Protein Kinase-G Signaling
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Topics: depression, post-stroke , hippocampus , isoflurane , mice , neurons

Critical Care Medicine: Clinical Science

Coagulopathy Underlying Rotational Thromboelastometry Derangements in Trauma Patients: A Prospective Observational Multicenter Study
This article has a Visual Abstract This article has a Video Abstract
Romein W. G. Dujardin, M.D.; Derek J. B. Kleinveld, Ph.D.; Christine Gaarder, Ph.D.; Karim Brohi, M.D.; Ross A. Davenport, Ph.D.; Nicola Curry, M.D.; Simon Stanworth, Ph.D.; Pär I. Johansson, Ph.D.; Jakob Stensballe, Ph.D.; Marc Maegele, Ph.D.; Nicole P. Juffermans, Ph.D.
Anesthesiology August 2022, Vol. 137, 232–242. https://doi.org/10.1097/ALN.0000000000004268
View Articletitled, Coagulopathy Underlying Rotational Thromboelastometry Derangements in Trauma Patients: A Prospective Observational Multicenter Study
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Topics: blood coagulation disorders , fibrinolysis , wounds and injuries , blood coagulation factors , cytolysis

Pain Medicine: Clinical Science

Estimates of Probabilities of Successful Development of Pain Medications: An Analysis of Pharmaceutical Clinical Development Programs from 2000 to 2020
Dermot P. Maher, M.D., M.S., M.H.S.; Chi Heem Wong, Ph.D.; Kien Wei Siah, Ph.D.; Andrew W. Lo, Ph.D.
Anesthesiology August 2022, Vol. 137, 243–251. https://doi.org/10.1097/ALN.0000000000004265
View Articletitled, Estimates of Probabilities of Successful Development of Pain Medications: An Analysis of Pharmaceutical Clinical Development Programs from 2000 to 2020
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Topics: analgesics , drug development , pain , pharmacy (field) , neuropathic pain

Education: Clinical Focus Review

Emerging Paradigms in the Prevention of Surgical Site Infection: The Patient Microbiome and Antimicrobial Resistance
CME Article
Dustin R. Long, M.D.; John C. Alverdy, M.D., F.A.C.S.; Monica S. Vavilala, M.D.
Anesthesiology August 2022, Vol. 137, 252–262. https://doi.org/10.1097/ALN.0000000000004267
View Articletitled, Emerging Paradigms in the Prevention of Surgical Site Infection: The Patient Microbiome and Antimicrobial Resistance
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Topics: drug resistance, microbial , microbiome , prevention , surgical wound infection , surgical procedures, operative

Education: Mind to Mind

Model Patient
Ellen Zhang, B.A.
Anesthesiology August 2022, Vol. 137, 263–264. https://doi.org/10.1097/ALN.0000000000004186
View Articletitled, Model Patient
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Topics: pain , chest , consciousness related finding , fingernail , hair

Anesthesiology Reflections from the Wood Library-Museum

A “Stryking” Anesthetic Room: Gorgeous in Borgess?
Anesthesiology August 2022, Vol. 137, 175. https://doi.org/10.1097/ALN.0000000000004294
View Articletitled, A “Stryking” Anesthetic Room: Gorgeous in Borgess?
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Vesalius’ Fabrica: Sublime Anatomy, Crude Physiology
Anesthesiology August 2022, Vol. 137, 186. https://doi.org/10.1097/ALN.0000000000004295
View Articletitled, Vesalius’ <em>Fabrica</em>: Sublime Anatomy, Crude Physiology
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Correspondence

Pain and Mobilization after Surgery: Comment
Mikita Fuchita, M.D.; Kyle J. Ridgeway, P.T., D.P.T.; Ana Fernandez-Bustamante, M.D., Ph.D.
Anesthesiology August 2022, Vol. 137, 265–266. https://doi.org/10.1097/ALN.0000000000004248
View Articletitled, Pain and Mobilization after Surgery: Comment
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Pain and Mobilization after Surgery: Reply
Eva Rivas, M.D.; Barak Cohen, M.D.; Xuan Pu, M.S.C.; Daniel I. Sessler, M.D.; Alparslan Turan, M.D.
Anesthesiology August 2022, Vol. 137, 266–267. https://doi.org/10.1097/ALN.0000000000004249
View Articletitled, Pain and Mobilization after Surgery: Reply
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Iatrogenic Pediatric Pneumothorax: Comment
James Xie, M.D.; Radhamangalam J. Ramamurthi, M.D.
Anesthesiology August 2022, Vol. 137, 267–268. https://doi.org/10.1097/ALN.0000000000004270
View Articletitled, Iatrogenic Pediatric Pneumothorax: Comment
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Iatrogenic Pediatric Pneumothorax: Reply
Shelly H. Pecorella, M.D.; L. Daniela Smith, B.S.; Timothy E. Smith, M.D.; T. Wesley Templeton, M.D.
Anesthesiology August 2022, Vol. 137, 268–269. https://doi.org/10.1097/ALN.0000000000004271
View Articletitled, Iatrogenic Pediatric Pneumothorax: Reply
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Reviews of Educational Material

Breathing for a Living: A Memoir
Kathryn Elizabeth McGoldrick, M.D., F.C.A.I. (Hon).
Anesthesiology August 2022, Vol. 137, 270–271. https://doi.org/10.1097/ALN.0000000000004257
View Articletitled, Breathing for a Living: A Memoir
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Topics: inspiration , respiration , cystic fibrosis
Making Healthcare Safe: The Story of the Patient Safety Movement
Fredrick K. Orkin, M.D., M.B.A., S.M. (Retired).
Anesthesiology August 2022, Vol. 137, 272–273. https://doi.org/10.1097/ALN.0000000000004261
View Articletitled, Making Healthcare Safe: The Story of the Patient Safety Movement
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Topics: patient safety

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