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This special article series on the Coronavirus Disease 2019 (COVID-19) pandemic provides:

  • An inside look at anesthesia practice from the epicenter of Wuhan, China

  • First-hand accounts on how anesthesiologists were affected – from airway and pulmonary management to practicing in temporary medical units

  • Recommendations from the joint task force of the Chinese Society of Anesthesiology and Chinese Association of Anesthesiologists on the management of patients in the perioperative setting and on emergency airway management outside of the operating room

  • Scholarly review and lessons about the novel 2019 coronavirus and the healthcare response which it has galvanized

  • Perspectives from anesthesiologists, pulmonologists, epidemiologists, and critical care physicians


Anesthesiologists may encounter and care for patients with Coronavirus 2019 (COVID-19) in their roles as experts in emergent airway management, acute and intensive care, and perioperative anesthesia. And the care they provide imposes a significant risk to their own health. Our goal is to bring Trusted Evidence on Coronavirus Disease 2019 (COVID-19) to our readers, as best we know it now (March 2020). In the interest of expediency, we are sharing these unedited proofs and all journal content related to Coronavirus Disease 2019 (COVID-19) will be freely available. 

New podcast:
COVID-19: Challenges of hemostasis and coagulopathy
Moderator: BobbieJean Sweitzer, M.D.
Participants: Jerrold Levy, M.D., and Jean M. Connors, M.D.

New! Elastomeric Respirators for COVID-19 and the Next Respiratory Virus Pandemic: Essential Design Elements 
T. Andrew Bowdle, M.D., Ph.D., F.A.S.E.; Srdjan Jelacic, M.D., F.A.S.E.; L. Silvia Munoz-Price, M.D., Ph.D.; Marty Cohen, Sc.D.; Sai Krishna M, M.S.E.; Lisa Brosseau, Sc.D.

Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study 
Xu Zhao, M.D.,; Chan Gao, M.D., Ph.D.; Feng Dai, Ph.D.; Miriam M. Treggiari, M.D., Ph.D., M.P.H.; Ranjit Deshpande, M.D., F.C.C.M.; Lingzhong Meng, M.D.

Emergency Airway Management in Patients with COVID-19: A Prospective International Multicenter Cohort Study
Danny J. N. Wong, F.R.C.A., Ph.D.; Kariem El-Boghdadly, F.R.C.A., M.Sc.; Ruth Owen, M.Sc.; Craig Johnstone, F.R.C.A.; Mark D. Neuman, M.D., M.Sc.; Paweł Andruszkiewicz, Ph.D.; Paul A. Baker, M.D., F.A.N.Z.C.A.; Bruce M. Biccard, Ph.D.; Gregory L. Bryson, M.D., F.R.C.P.C., M.Sc.; Matthew T. V. Chan, M.B.B.S., Ph.D.; Ming Hua Cheng, M.Med.; Ki Jinn Chin, F.R.C.P.C.; Mark Coburn, M.D.; Malin Jonsson Fagerlund, M.D., Ph.D.; Clara A. Lobo, M.D.; Eugenio Martinez-Hurtado, M.D.; Sheila N. Myatra, M.D.; Paul S. Myles, D.Sc.; Guillermo Navarro, M.D.; Ellen O’Sullivan, F.R.C.A., F.C.A.I.; Laura Pasin, M.D.; Kathleen Quintero, M.D.; Nabil Shallik, M.D.; Faisal Shamim, F.C.P.S.; Wilton A. van Klei, M.D., Ph.D.; Imran Ahmad, F.R.C.A.

Concordance of Upper and Lower Respiratory Tract Samples for SARS-CoV-2 in Pediatric Patients: Research Letter 
Elaina E. Lin, M.D. ; Elikplim H. Akaho, M.D., M.H.S.; Anna Sobilo, M.D.; Allison M. Blatz, M.D.; William R. Otto, M.D.; Audrey R. Odom John, M.D., Ph.D.

Greater Fibrinolysis Resistance but No Greater Platelet Aggregation in Critically Ill COVID-19 Patients
Christoph Heinz, M.D.; Wolfgang Miesbach, M.D.; Eva Herrmann, Ph.D.; Michael Sonntagbauer, M.D.; Florian Raimann, M.D.; Kai Zacharowski, M.D., Ph.D.; Christian F. Weber, M.D.; Elisabeth H. Adam, M.D.

COVID-19–Associated Coagulopathy: Less Fibrinolysis Can Be More Harmful!
Klaus Görlinger, M.D.; Jerrold H. Levy, M.D., F.A.H.A., F.C.C.M.

COVID-19, Personal Protective Equipment, and Human Performance 
Keith J. Ruskin, M.D., F.R.Ae.S.; Anna Clebone Ruskin, M.D.; Brian T. Musselman, C.As.P.; Jaime Rivas Harvey, C.As.P.; Thomas E. Nesthus, Ph.D.; Michael O’Connor, M.D.

Aerosol Retention Characteristics of Barrier Devices
Richard L. Fidler, Ph.D., M.B.A., C.R.N.A., N.P.; Christopher R. Niedek, B.S.; Justin J. Teng, M.D.; Mary E. Sturgeon, D.M.D.; Qi Zhang, Ph.D.; David L. Robinowitz, M.D., M.H.S., M.S.; Jan Hirsch, Ph.D., M.D.

“Silent” Presentation of Hypoxemia and Cardiorespiratory Compensation in COVID-19
Philip E. Bickler, M.D., Ph.D.; John R. Feiner, M.D.; Michael S. Lipnick, M.D.; William McKleroy, M.D.

Acute Respiratory Distress Syndrome: Contemporary Management and Novel Approaches during COVID-19
George W. Williams, M.D.; Nathaniel K. Berg, B.S.; Alexander Reskallah, M.D.; Xiaoyi Yuan, Ph.D.; Holger K. Eltzschig, M.D., Ph.D.

Quality Improvement and In Situ Simulation for High-quality Crisis Care: Lessons from a COVID-19 Field Hospital
Meghan B. Lane-Fall, M.D., M.S.H.P., F.C.C.M., Joshua H. Atkins, M.D., Ph.D., C.P.E.

Development of Rapid Response Capabilities in a Large COVID-19 Alternate Care Site Using Failure Modes and Effect Analysis with In Situ Simulation
Nadav Levy, M.D.; Liana Zucco, M.B.B.S., F.R.C.A.; Richard J. Ehrlichman, M.D., F.A.C.S.; Ronald E. Hirschberg, M.D.; Stacy Hutton Johnson, Ph.D., R.N.; Michael B. Yaffe, M.D., Ph.D., Col. (ret); Satya Krishna Ramachandran, M.D.; Somnath Bose, M.D.; Akiva Leibowitz, M.D.

Images from the Frontlines of the COVID-19 Pandemic
Differential Ventilation Using Flow Control Valves as a Potential Bridge to Full Ventilatory Support during the COVID-19 Crisis: From Bench to Bedside
Matthew A. Levin, M.D.; Anjan Shah, M.D.; Ronak Shah, M.D.; Erica Kane, M.D., M.P.H.; George Zhou, M.D.; James B. Eisenkraft, M.D.; Martin D. Chen, M.D.; for the Mount Sinai HELPS Innovate Group

Evolving Role of Anesthesiology Intensivists in Cardiothoracic Critical Care
Kenneth T. Shelton, M.D.; Jeanine P. Wiener-Kronish, M.D.

Response of Chinese Anesthesiologists to the COVID-19 Outbreak
Hong-Fei Zhang, M.D., Ph.D.; Lulong Bo, M.D., Ph.D.; Yun Lin, M.D., Ph.D.; Feng-Xian Li, M.D., Ph.D.; Shujun Sun, M.D.; Hong-Bin Lin, M.D.; Shi-Yuan Xu, M.D.; Jinjun Bian, M.D., Ph.D.; Shanglong Yao, M.D., Ph.D.; Xiangdong Chen, M.D., Ph.D. Lingzhong Meng, M.D.; Xiaoming Deng, M.D., Ph.D.

Preventing Infection of Patients and Healthcare Workers Should Be the New Normal in the Era of Novel Coronavirus Epidemics
Andrew Bowdle, M.D., Ph.D., F.A.S.E.; L. Silvia Munoz-Price, M.D., Ph.D.

Establishing and Managing a Temporary Coronavirus Disease 2019 Specialty Hospital in Wuhan, China
Weihong Zhu, M.D.; Yang Wang, M.D.; Kui Xiao, M.D.; Huilin Zhang, M.D.; Yi Tian, M.D.; Sean P. Clifford, M.D.; Junmei Xu, M.D.; Jiapeng Huang, M.D., Ph.D.

COVID-19 Infection: Implications for Perioperative and Critical Care Physicians
John R. Greenland, M.D., Ph.D., Marilyn D. Michelow, M.D., Linlin Wang, M.D., Ph.D., Martin J. London, M.D.
Listen to the accompanying podcast, an interview with lead author Dr. Greenland

Perioperative Management of Patients Infected with the Novel Coronavirus: Recommendation from the Joint Task Force of the Chinese Society of Anesthesiology and Chinese Association of Anesthesiologists
Xiangdong Chen, M.D., Ph.D.; Yanhong Liu, M.D., Ph.D.; Yahong Gong, M.D.; Xiangyang Guo, M.D., Ph.D.; Mingzhang Zuo, M.D., Ph.D.; Jun Li, M.D., Ph.D.; Wenzhu Shi, M.D., Ph.D.; Hao Li, M.D., Ph.D.; Xiaohan Xu, M.D.; Weidong Mi, M.D., Ph.D. Yuguang Huang, M.D., Ph.D.
Listen to the accompanying podcast, an interview with senior author Dr. Huang and Dr. Jiang

Intubation and Ventilation Amid COVID-19 Outbreak
Lingzhong Meng, M.D.; Haibo Qiu, M.D.; Li Wan, M.D.; Yuhang Ai, M.D.; Zhanggang Xue, M.D.; Qulian Guo, M.D.; Ranjit Deshpande, M.D.; Lina Zhang, M.D., Ph.D.; Jie Meng, M.D., Ph.D.; Chuanyao Tong, M.D. Hong Liu, M.D.; Lize Xiong, M.D., Ph.D.
Novel Coronavirus 2019 and Anesthesiology
Evan D. Kharasch, M.D., Ph.D.; Yandong Jiang, M.D., Ph.D.

Balancing Supply and Demand for Blood during the COVID-19 Pandemic
Eric A. Gehrie, M.D.; Steven M. Frank, M.D.; Susan M. Goobie, M.D., F.R.C.P.C.

As rapidly as the coronavirus is spreading, so too is our ability to understand it, and the pace of discovery is unheralded. It is not without understanding that a journal which publishes monthly cannot keep abreast of these daily events. In addition to the articles in this issue of ANESTHESIOLOGY, more comprehensive and more timely resources are available. These include the World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), European Centre for Disease Prevention and Control, and university and research center websites. The American Society of Anesthesiologists (ASA) has created and is continually updating COVID-19 resources for the anesthesia community, including clinical FAQs and guidance for caring for patients with known or suspected COVID-19 infection.

For patient care the CDC’s Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Disease 2019 (COVID-19) and Interim Infection Prevention and Control Recommendations for Patients with Confirmed Coronavirus Disease 2019 (COVID-19) or Persons Under Investigation for COVID-19 in Healthcare Settings may be particularly helpful.

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