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Classic Papers Revisited: An Early Study of Cardioprotection by Volatile Anesthetics: A Behind-the-scenes Look

David C. Warltier, M.D., Ph.D., F.A.H.A., F.A.C.C.

Anesthesiology. September 2018: 129(3):576–579

https://doi.org/10.1097/ALN.0000000000002305

Published: September 2018

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Articles

Failure of Isoflurane Cardiac Preconditioning in Obese Type 2 Diabetic Mice Involves Aberrant Regulation of MicroRNA-21, Endothelial Nitric-oxide Synthase, and Mitochondrial Complex I

Zhi-Dong Ge, M.D., Ph.D., Yingchuan Li, M.D., Ph.D., Shigang Qiao, M.D., Ph.D., Xiaowen Bai, M.D., Ph.D., David C. Warltier, M.D., Ph.D., Judy R. Kersten, M.D., Zeljko J. Bosnjak, Ph.D., Mingyu Liang, M.B., Ph.D.

Anesthesiology. January 2018: 128(1):117–129

https://doi.org/10.1097/ALN.0000000000001926

Published: January 2018

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Articles

MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia–Reperfusion Injury via Akt/Nitric Oxide Synthase/Mitochondrial Permeability Transition Pore Pathway

Shigang Qiao, M.D., Jessica M. Olson, Ph.D., Mark Paterson, B.S., Yasheng Yan, B.S., Ivan Zaja, B.S., Yanan Liu, Ph.D., Matthias L. Riess, M.D., Ph.D., Judy R. Kersten, M.D., Mingyu Liang, Ph.D., David C. Warltier, M.D., Ph.D., Zeljko J. Bosnjak, Ph.D., Zhi-Dong Ge, M.D., Ph.D.

Anesthesiology. October 2015: 123(4):786–798

https://doi.org/10.1097/ALN.0000000000000807

Published: October 2015

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Articles

Isoflurane Favorably Modulates Guanosine Triphosphate Cyclohydrolase-1 and Endothelial Nitric Oxide Synthase during Myocardial Ischemia and Reperfusion Injury in Rats

Ines Baotic, M.D., Dorothee Weihrauch, Ph.D., Jesse Procknow, Ph.D., Jeanette Vasquez-Vivar, Ph.D., Zhi-Dong Ge, M.D., Ph.D., Shaan Sudhakaran, M.D., David C. Warltier, M.D., Ph.D., Judy R. Kersten, M.D.

Anesthesiology. September 2015: 123(3):582–589

https://doi.org/10.1097/ALN.0000000000000778

Published: September 2015

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Articles

Cardioprotection during Diabetes: The Role of Mitochondrial DNA

Maria Muravyeva, M.D., Ph.D., Ines Baotic, M.D., Martin Bienengraeber, Ph.D., Jozef Lazar, Ph.D., Zeljko J. Bosnjak, Ph.D., Filip Sedlic, M.D., Ph.D., David C. Warltier, M.D., Ph.D., Judy R. Kersten, M.D.

Anesthesiology. April 2014: 120(4):870–879

https://doi.org/10.1097/ALN.0000000000000107

Published: April 2014

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Articles

Isoflurane Differentially Modulates Mitochondrial Reactive Oxygen Species Production via Forward versus Reverse Electron Transport Flow: Implications for Preconditioning

Naoyuki Hirata, M.D., Ph.D., Yon Hee Shim, M.D., Danijel Pravdic, M.D., Ph.D., Nicole L. Lohr, M.D., Ph.D., Philip F. Pratt, Ph.D., Dorothee Weihrauch, D.V.M., Ph.D., Judy R. Kersten, M.D., David C. Warltier, M.D., Ph.D., Zeljko J. Bosnjak, Ph.D., Martin Bienengraeber, Ph.D.

Anesthesiology. September 2011: 115(3):531–540

https://doi.org/10.1097/ALN.0b013e31822a2316

Published: September 2011

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Articles

Hyperglycemia Adversely Modulates Endothelial Nitric Oxide Synthase during Anesthetic Preconditioning through Tetrahydrobiopterin– and Heat Shock Protein 90–mediated Mechanisms

Julien Amour, M.D., Ph.D., Anna K. Brzezinska, Ph.D., Zachary Jager, M.D., Corbin Sullivan, M.D., Dorothee Weihrauch, D.V.M., Ph.D., Jianhai Du, Ph.D., Nikolina Vladic, M.D., Yang Shi, Ph.D., David C. Warltier, M.D., Ph.D., Phillip F. Pratt, Ph.D., Judy R. Kersten, M.D., F.A.C.C.

Anesthesiology. March 2010: 112(3):576–585

https://doi.org/10.1097/ALN.0b013e3181cded1f

Published: March 2010

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Articles

Isoflurane Postconditioning Protects against Reperfusion Injury by Preventing Mitochondrial Permeability Transition by an Endothelial Nitric Oxide Synthase–dependent Mechanism

Zhi-Dong Ge, M.D., Ph.D., Danijel Pravdic, M.D., Martin Bienengraeber, Ph.D., Phillip F. Pratt, Ph.D., John A. Auchampach, Ph.D., Garrett J. Gross, Ph.D., Judy R. Kersten, M.D., F.A.C.C., David C. Warltier, M.D., Ph.D.

Anesthesiology. January 2010: 112(1):73–85

https://doi.org/10.1097/ALN.0b013e3181c4a607

Published: January 2010

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Articles

Role of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase during Early Anesthetic and Ischemic Preconditioning

Julien Amour, M.D., Ph.D., Anna K. Brzezinska, Ph.D., Dorothee Weihrauch, D.V.M., Ph.D., Amie R. Billstrom, B.S., Jacek Zielonka, Ph.D., John G. Krolikowski, B.S., Martin W. Bienengraeber, Ph.D., David C. Warltier, M.D., Ph.D., Philip F. Pratt, Ph.D., Judy R. Kersten, M.D., F.A.C.C.

Anesthesiology. February 2009: 110(2):317–325

https://doi.org/10.1097/ALN.0b013e3181942cb4

Published: February 2009

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Articles

Zeljko J. Bosnjak, Ph.D., Recipient of the 2008 Excellence in Research Award

David C. Warltier, M.D., Ph.D.

Anesthesiology. September 2008: 109(3):371–373

https://doi.org/10.1097/ALN.0b013e31818344fd

Published: September 2008

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Articles

Simvastatin Restores Ischemic Preconditioning in the Presence of Hyperglycemia through a Nitric Oxide–mediated Mechanism

Weidong Gu, M.D., Franz Kehl, M.D., John G. Krolikowski, B.A., Paul S. Pagel, M.D., Ph.D., David C. Warltier, M.D., Ph.D., Judy R. Kersten, M.D.

Anesthesiology. April 2008: 108(4):634–642

https://doi.org/10.1097/ALN.0b013e3181672590

Published: April 2008

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Articles

New Frontiers in the Evaluation of Cardiac Patients for Noncardiac Surgery

Ronit Lavi, M.D., Shahar Lavi, M.D., Elena Daghini, M.D., Lilach O. Lerman, M.D. Ph.D., David C. Warltier, M.D., Ph.D.

Anesthesiology. December 2007: 107(6):1018–1028

https://doi.org/10.1097/01.anes.0000287613.49204.94

Published: December 2007

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Articles

Nitric Oxide: Involvement in the Effects of Anesthetic Agents

Noboru Toda, M.D., Ph.D., Hiroshi Toda, M.D., Ph.D., Yoshio Hatano, M.D., Ph.D., David C. Warltier, M.D., Ph.D.

Anesthesiology. November 2007: 107(5):822–842

https://doi.org/10.1097/01.anes.0000287213.98020.b6

Published: November 2007

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Articles

Intracranial Venous Thrombosis in the Parturient

Ellen M. Lockhart, M.D., Curtis L. Baysinger, M.D., David C. Warltier, M.D., Ph.D.

Anesthesiology. October 2007: 107(4):652–658

https://doi.org/10.1097/01.anes.0000282103.70955.c4

Published: October 2007

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Articles

Sedation and Anesthesia Care for Ophthalmologic Surgery during Local/Regional Anesthesia

Mary Ann Vann, M.D., Babatunde O. Ogunnaike, M.D., Girish P. Joshi, M.B., B.S., M.D., F.F.A.R.C.S.I., David C. Warltier, M.D., Ph.D.

Anesthesiology. September 2007: 107(3):502–508

https://doi.org/10.1097/01.anes.0000278996.01831.8d

Published: September 2007

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Articles

Transesophageal Echocardiography and Cardiovascular Sources of Embolism: Implications for Perioperative Management

Christine Ngukhoon Tan, M.B., B.S., F.R.C.A., Alan G. Fraser, F.R.C.P., F.E.S.C., David C. Warltier, M.D., Ph.D.

Anesthesiology. August 2007: 107(2):333–346

https://doi.org/10.1097/01.anes.0000270733.26234.56

Published: August 2007

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Articles

Advances in and Limitations of Up-and-down Methodology: A Précis of Clinical Use, Study Design, and Dose Estimation in Anesthesia Research

Nathan L. Pace, M.D., M.Stat., Mario P. Stylianou, Ph.D., David C. Warltier, M.D., Ph.D., Editor

Anesthesiology. July 2007: 107(1):144–152

https://doi.org/10.1097/01.anes.0000267514.42592.2a

Published: July 2007

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Articles

Volume Replacement Therapy during Major Orthopedic Surgery Using Voluven® (Hydroxyethyl Starch 130/0.4) or Hetastarch

Sweeta D. Gandhi, M.D., Richard B. Weiskopf, M.D., Cornelius Jungheinrich, M.D., Robert Koorn, M.D., Diane Miller, M.D., Robert E. Shangraw, M.D., Ph.D., Donald S. Prough, M.D., Daniela Baus, M.S., Frank Bepperling, Ph.D., David C. Warltier, M.D., Ph.D.

Anesthesiology. June 2007: 106(6):1120–1127

https://doi.org/10.1097/01.anes.0000265422.07864.37

Published: June 2007

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Articles

What Tidal Volumes Should Be Used in Patients without Acute Lung Injury?

Marcus J. Schultz, M.D., Ph.D., Jack J. Haitsma, M.D., Ph.D., Arthur S. Slutsky, M.D., Ognjen Gajic, M.D., David C. Warltier, M.D., Ph.D.

Anesthesiology. June 2007: 106(6):1226–1231

https://doi.org/10.1097/01.anes.0000267607.25011.e8

Published: June 2007

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Articles

Hyperoxia-induced Tissue Hypoxia: A Danger?

Ivy F. Forkner, B.S., Claude A. Piantadosi, M.D., Nicola Scafetta, Ph.D., Richard E. Moon, M.D., David C. Warltier, M.D., Ph.D.

Anesthesiology. May 2007: 106(5):1051–1055

https://doi.org/10.1097/01.anes.0000265167.14383.44

Published: May 2007

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NARROW

Classic Papers Revisited: An Early Study of Cardioprotection by Volatile Anesthetics: A Behind-the-scenes Look

Failure of Isoflurane Cardiac Preconditioning in Obese Type 2 Diabetic Mice Involves Aberrant Regulation of MicroRNA-21, Endothelial Nitric-oxide Synthase, and Mitochondrial Complex I

MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia–Reperfusion Injury via Akt/Nitric Oxide Synthase/Mitochondrial Permeability Transition Pore Pathway

Isoflurane Favorably Modulates Guanosine Triphosphate Cyclohydrolase-1 and Endothelial Nitric Oxide Synthase during Myocardial Ischemia and Reperfusion Injury in Rats

Cardioprotection during Diabetes: The Role of Mitochondrial DNA

Isoflurane Differentially Modulates Mitochondrial Reactive Oxygen Species Production via Forward versus Reverse Electron Transport Flow: Implications for Preconditioning

Hyperglycemia Adversely Modulates Endothelial Nitric Oxide Synthase during Anesthetic Preconditioning through Tetrahydrobiopterin– and Heat Shock Protein 90–mediated Mechanisms

Isoflurane Postconditioning Protects against Reperfusion Injury by Preventing Mitochondrial Permeability Transition by an Endothelial Nitric Oxide Synthase–dependent Mechanism

Role of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase during Early Anesthetic and Ischemic Preconditioning

Zeljko J. Bosnjak, Ph.D., Recipient of the 2008 Excellence in Research Award

Simvastatin Restores Ischemic Preconditioning in the Presence of Hyperglycemia through a Nitric Oxide–mediated Mechanism

New Frontiers in the Evaluation of Cardiac Patients for Noncardiac Surgery

Nitric Oxide: Involvement in the Effects of Anesthetic Agents

Intracranial Venous Thrombosis in the Parturient

Sedation and Anesthesia Care for Ophthalmologic Surgery during Local/Regional Anesthesia

Transesophageal Echocardiography and Cardiovascular Sources of Embolism: Implications for Perioperative Management

Advances in and Limitations of Up-and-down Methodology: A Précis of Clinical Use, Study Design, and Dose Estimation in Anesthesia Research

Volume Replacement Therapy during Major Orthopedic Surgery Using Voluven® (Hydroxyethyl Starch 130/0.4) or Hetastarch

What Tidal Volumes Should Be Used in Patients without Acute Lung Injury?

Hyperoxia-induced Tissue Hypoxia: A Danger?

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