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Erik Olofsen
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Articles

Neurocognitive effect of biased µ-opioid receptor agonist oliceridine, a utility function analysis and comparison with morphine

Laurence Moss, MD, Hemme Hijma, PhD, Mark Demitrack, MD, Jessica Kim, MSc, Geert Jan Groeneveld, MD PhD, Monique van Velzen, PhD, Marieke Niesters, MD PhD, Erik Olofsen, PhD, Albert Dahan, MD PhD
Publication: Anesthesiology
Anesthesiology. September 2023: 10.1097/ALN.0000000000004758
https://doi.org/10.1097/ALN.0000000000004758
Published: September 2023
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Opioid Overdose: Limitations in Naloxone Reversal of Respiratory Depression and Prevention of Cardiac Arrest

CME Article
Maarten van Lemmen, B.Sc., Jeffrey Florian, Ph.D., Zhihua Li, Ph.D., Monique van Velzen, Ph.D., Eveline van Dorp, M.D., Ph.D., Marieke Niesters, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Erik Olofsen, Ph.D., Rutger van der Schrier, M.D., David G. Strauss, M.D., Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. September 2023: 139(3):342–353
https://doi.org/10.1097/ALN.0000000000004622
Published: September 2023
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Morphine and Hydromorphone Effects, Side Effects, and Variability: A Crossover Study in Human Volunteers

This article has a Visual Abstract This article has a Video Abstract This article has an Audio Podcast
Konrad Meissner, M.D., Albert Dahan, M.D., Ph.D., Erik Olofsen, Ph.D., Christine Göpfert, M.D., Jane Blood, R.N., B.S.N., Johannes Wieditz, Ph.D., Evan D. Kharasch, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. July 2023: 139(1):16–34
https://doi.org/10.1097/ALN.0000000000004567
Published: July 2023
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Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic–Pharmacodynamic Comparison with Morphine

This article has a Visual Abstract
Pieter Simons, M.D., Rutger van der Schrier, M.D., Maarten van Lemmen, B.Sc., Simone Jansen, M.D., Kiki W.K. Kuijpers, B.Sc., Monique van Velzen, Ph.D., Elise Sarton, M.D., Ph.D., Todd Nicklas, M.S.N., Cathy Michalsky, M.Sc., Mark A. Demitrack, M.D., Michael Fossler, Pharm.D., Ph.D., F.C.P., Erik Olofsen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D. Ph.D.
Publication: Anesthesiology
Anesthesiology. March 2023: 138(3):249–263
https://doi.org/10.1097/ALN.0000000000004473
Published: March 2023
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Ketamine Pharmacodynamics Entangled: Reply

Albert Dahan, M.D., Ph.D., Erik Olofsen, Ph.D., Thomas K. Henthorn, M.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. December 2022: 137(6):748–749
https://doi.org/10.1097/ALN.0000000000004350
Published: December 2022
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Respiratory Effects of the Atypical Tricyclic Antidepressant Tianeptine in Human Models of Opioid-induced Respiratory Depression

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Hyke Algera, M.D., Rutger van der Schrier, M.D., David Cavalla, Ph.D., Monique van Velzen, Ph.D., Margot Roozekrans, M.D., Ph.D., Alison McMorn, Ph.D., Michael Snape, Ph.D., Joseph P. Horrigan, M.D., Stuart Evans, M.A., Bernard Kiernan, Ph.D., Elise Sarton, M.D., Ph.D., Erik Olofsen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. October 2022: 137(4):446–458
https://doi.org/10.1097/ALN.0000000000004324
Published: October 2022
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Ketamine Psychedelic and Antinociceptive Effects Are Connected

This article has a Visual Abstract
Erik Olofsen, Ph.D., Jasper Kamp, Ph.D., Thomas K. Henthorn, M.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. May 2022: 136(5):792–801
https://doi.org/10.1097/ALN.0000000000004176
Published: May 2022
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Does Divergence Exist between Animal and Human Data on the Effect of Cebranopadol?

Albert Dahan, M.D., Ph.D., Erik Olofsen, Ph.D.
Publication: Anesthesiology
Anesthesiology. September 2021: 135(3):382–383
https://doi.org/10.1097/ALN.0000000000003885
Published: September 2021
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Ketamine Pharmacokinetics: A Systematic Review of the Literature, Meta-analysis, and Population Analysis

Jasper Kamp, Pharm.D., Erik Olofsen, Ph.D., Thomas K. Henthorn, M.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D., Ph.D., for the Ketamine Pharmacokinetic Study Group
Publication: Anesthesiology
Anesthesiology. December 2020: 133(6):1192–1213
https://doi.org/10.1097/ALN.0000000000003577
Published: December 2020
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Benefit and Risk Evaluation of Biased μ-Receptor Agonist Oliceridine versus Morphine

Albert Dahan, M.D., Ph.D., C. Jan van Dam, M.D., Marieke Niesters, M.D., Ph.D., Monique van Velzen, Ph.D., Michael J. Fossler, Pharm.D., Ph.D., Mark A. Demitrack, M.D., Erik Olofsen, Ph.D.
Publication: Anesthesiology
Anesthesiology. September 2020: 133(3):559–568
https://doi.org/10.1097/ALN.0000000000003441
Published: September 2020
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Analgesic and Respiratory Depressant Effects of R-dihydroetorphine: A Pharmacokinetic–Pharmacodynamic Analysis in Healthy Male Volunteers

Erik Olofsen, Ph.D., Merel Boom, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Monique van Velzen, Ph.D., Paul Baily, B.Sc., Kevin J. Smith, Ph.D., Alexander Oksche, M.D., Ph.D., Albert Dahan, M.D., Ph.D., Marieke Niesters, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. December 2019: 131(6):1327–1339
https://doi.org/10.1097/ALN.0000000000002991
Published: December 2019
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Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia: A Randomized Controlled Trial

Fleur S. Meijer, M.D., Chris H. Martini, M.D., Ph.D., Suzanne Broens, M.D., Martijn Boon, M.D., Marieke Niesters, M.D., Ph.D., Leon Aarts, M.D., Ph.D., Erik Olofsen, Ph.D., Monique van Velzen, Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. May 2019: 130(5):745–755
https://doi.org/10.1097/ALN.0000000000002634
Published: May 2019
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Where’s the Beef?: How Much Can We Skimp on Pharmacokinetic–Pharmacodynamic Data?

Thomas K. Henthorn, M.D., Erik Olofsen, Ph.D.
Publication: Anesthesiology
Anesthesiology. February 2019: 130(2):186–188
https://doi.org/10.1097/ALN.0000000000002552
Published: February 2019
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Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S(+) and R(–) Ketamine Concentrations

Thomas K. Henthorn, M.D., Michael J. Avram, Ph.D., Albert Dahan, M.D., Ph.D., Lars L. Gustafsson, M.D., Ph.D., Jan Persson, M.D., Ph.D., Tom C. Krejcie, M.D., Erik Olofsen, Ph.D.
Publication: Anesthesiology
Anesthesiology. August 2018: 129(2):260–270
https://doi.org/10.1097/ALN.0000000000002265
Published: August 2018
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Benefit versus Severe Side Effects of Opioid Analgesia: Novel Utility Functions of Probability of Analgesia and Respiratory Depression

Margot Roozekrans, M.D., Rutger van der Schrier, M.D., Leon Aarts, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D., Ph.D., Erik Olofsen, Ph.D.
Publication: Anesthesiology
Anesthesiology. May 2018: 128(5):932–942
https://doi.org/10.1097/ALN.0000000000002138
Published: May 2018
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Pharmacokinetics and Bioavailability of Inhaled Esketamine in Healthy Volunteers

Kelly Jonkman, M.D., Andreas Duma, M.D., Erik Olofsen, M.Sc., Thomas Henthorn, M.D., Monique van Velzen, Ph.D., René Mooren, B.Sc., Liesbeth Siebers, B.Sc., Jojanneke van den Beukel, B.Sc., Leon Aarts, M.D., Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. October 2017: 127(4):675–683
https://doi.org/10.1097/ALN.0000000000001798
Published: October 2017
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An Allometric Model of Remifentanil Pharmacokinetics and Pharmacodynamics

Douglas J. Eleveld, Ph.D., Johannes H. Proost, Pharm.D., Hugo Vereecke, M.D., Ph.D., Anthony R. Absalom, M.D., Ph.D., Erik Olofsen, M.Sc., Jaap Vuyk, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. June 2017: 126(6):1005–1018
https://doi.org/10.1097/ALN.0000000000001634
Published: June 2017
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Respiratory Effects of the Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist, Cebranopadol, in Healthy Human Volunteers

Albert Dahan, M.D., Ph.D., Merel Boom, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Justin Hay, Ph.D., Geert Jan Groeneveld, M.D., Ph.D., Meike Neukirchen, Ph.D., John Bothmer, Ph.D., Leon Aarts, M.D., Ph.D., Erik Olofsen, M.Sc.
Publication: Anesthesiology
Anesthesiology. April 2017: 126(4):697–707
https://doi.org/10.1097/ALN.0000000000001529
Published: April 2017
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Influence of Ethanol on Oxycodone-induced Respiratory Depression: A Dose-escalating Study in Young and Elderly Individuals

Rutger van der Schrier, M.D., Margot Roozekrans, M.D., Erik Olofsen, M.Sc., Leon Aarts, M.D., Ph.D., Monique van Velzen, Ph.D., Merijn de Jong, B.Sc., Albert Dahan, M.D., Ph.D., Marieke Niesters, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. March 2017: 126(3):534–542
https://doi.org/10.1097/ALN.0000000000001505
Published: March 2017
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Big Brain, Small World?

Erik Olofsen, M.Sc., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. January 2015: 122(1):8–11
https://doi.org/10.1097/ALN.0000000000000517
Published: January 2015
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