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Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine

John J. Savarese, M.D., Hiroshi Sunaga, M.D., Jeff D. McGilvra, Ph.D., Matthew R. Belmont, M.D., Matthew T. Murrell, M.D., Ph.D., Erin Jeannotte, L.V.T., R.Lat.G., Farrell E. Cooke, B.S., William B. Wastila, Ph.D., Paul M. Heerdt, M.D., Ph.D.

Anesthesiology. November 2018: 129(5):970–988

https://doi.org/10.1097/ALN.0000000000002408

Published: November 2018

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Articles

Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers

Josh D. Kaullen, Pharm.D., Joel S. Owen, Ph.D., Kim L. R. Brouwer, Pharm.D., Ph.D., Paul M. Heerdt, M.D., Ph.D., Cynthia A. Lien, M.D., John J. Savarese, M.D., Virginia D. Schmith, Ph.D.

Anesthesiology. June 2018: 128(6):1107–1116

https://doi.org/10.1097/ALN.0000000000002157

Published: June 2018

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Articles

Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man

Paul M. Heerdt, M.D., Ph.D., Hiroshi Sunaga, M.D., Joel S. Owen, Ph.D., Matthew T. Murrell, M.D., Ph.D., Jaideep K. Malhotra, M.D., Deena Godfrey, B.A., Michelle Steinkamp, R.N., Peter Savard, M.D., John J. Savarese, M.D., Cynthia A. Lien, M.D.

Anesthesiology. December 2016: 125(6):1136–1143

https://doi.org/10.1097/ALN.0000000000001386

Published: December 2016

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Articles

Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine—Additional Studies of Safety and Efficacy in the Anesthetized Rhesus Monkey and Cat

Hiroshi Sunaga, M.D., John J. Savarese, M.D., Jeff D. McGilvra, Ph.D., Paul M. Heerdt, M.D., Ph.D., Matthew R. Belmont, M.D., Scott G. Van Ornum, Ph.D., Matthew T. Murrell, M.D., Ph.D., Jaideep K. Malhotra, M.D., Peter M. Savard, M.D., Erin Jeannotte, L.V.T., R.Lat.G., Bryce J. Petty, B.A., Erica Allen, Ph.D., Gilbert W. Carnathan, Ph.D.

Anesthesiology. October 2016: 125(4):732–743

https://doi.org/10.1097/ALN.0000000000001254

Published: October 2016

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Articles

Rapid Chemical Antagonism of Neuromuscular Blockade by l-Cysteine Adduction to and Inactivation of the Olefinic (Double-bonded) Isoquinolinium Diester Compounds Gantacurium (AV430A), CW 002, and CW 011

John J. Savarese, M.D., Jeff D. McGilvra, Ph.D., Hiroshi Sunaga, M.D., Matthew R. Belmont, M.D., Scott G. Van Ornum, Ph.D., Peter M. Savard, M.D., Paul M. Heerdt, M.D., Ph.D.

Anesthesiology. July 2010: 113(1):58–73

https://doi.org/10.1097/ALN.0b013e3181dc1b5b

Published: July 2010

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Articles

Gantacurium and CW002 Do Not Potentiate Muscarinic Receptor-mediated Airway Smooth Muscle Constriction in Guinea Pigs

Hiroshi Sunaga, M.D., Yi Zhang, M.D., John J. Savarese, M.D., Charles W. Emala, M.D.

Anesthesiology. April 2010: 112(4):892–899

https://doi.org/10.1097/ALN.0b013e3181d32016

Published: April 2010

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Articles

Cysteine Reversal of the Novel Neuromuscular Blocking Drug CW002 in Dogs: Pharmacodynamics, Acute Cardiovascular Effects, and Preliminary Toxicology

Hiroshi Sunaga, M.D., Jaideep K. Malhotra, M.D., Edward Yoon, B.S., John J. Savarese, M.D., Paul M. Heerdt, M.D., Ph.D.

Anesthesiology. April 2010: 112(4):900–909

https://doi.org/10.1097/ALN.0b013e3181d31f8c

Published: April 2010

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Articles

Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs

Paul M. Heerdt, M.D., Ph.D., Jaideep K. Malhotra, M.D., Brian Y. Pan, B.S., Hiroshi Sunaga, M.D., John J. Savarese, M.D.

Anesthesiology. April 2010: 112(4):910–916

https://doi.org/10.1097/ALN.0b013e3181d31f71

Published: April 2010

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Articles

GW280430A: Pharmacodynamics and Potential Adverse Effects

John J. Savarese, M.D.

Anesthesiology. April 2005: 102(4):863–865

https://doi.org/10.1097/00000542-200504000-00027

Published: April 2005

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Articles

Cardiopulmonary Effects of the Novel Neuromuscular Blocking Drug GW280430A (AV430A) in Dogs

Paul M. Heerdt, M.D., Ph.D., Richard Kang, B.S., Andrew The’, B.S., Mir Hashim, Ph.D., Robert J. Mook, Ph.D., John J. Savarese, M.D.

Anesthesiology. April 2004: 100(4):846–851

https://doi.org/10.1097/00000542-200404000-00014

Published: April 2004

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Articles

Clinical Pharmacology of GW280430A in Humans

Matthew R. Belmont, M.D., Cynthia A. Lien, M.D., Joseph Tjan, M.D., Eleanor Bradley, C.R.N.A., Brenna Stein, C.R.N.A., Sanjay S. Patel, Ph.D., John J. Savarese, M.D.

Anesthesiology. April 2004: 100(4):768–773

https://doi.org/10.1097/00000542-200404000-00004

Published: April 2004

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Articles

Preclinical Pharmacology of GW280430A (AV430A) in the Rhesus Monkey and in the Cat: A Comparison with Mivacurium

John J. Savarese, M.D., Matthew R. Belmont, M.D., Mir A. Hashim, Ph.D., Robert A. Mook, Ph.D., Eric E. Boros, Ph.D., Vicente Samano, Ph.D., Sanjay S. Patel, Ph.D., Paul L. Feldman, Ph.D., Jan-Ake I. Schultz, M.D., Michael McNulty, Ph.D., Timothy Spitzer, Ph.D., Douglas L. Cohn, D.V.M., Philip Morgan, Ph.D., William B. Wastila, Ph.D.

Anesthesiology. April 2004: 100(4):835–845

https://doi.org/10.1097/00000542-200404000-00013

Published: April 2004

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Articles

Room 224-226, 10/16/2000 9: 00 AM - 10: 30 AM (PD) Early Antagonism of Neuromuscular Block: Is It Effective? : A-1039

Cynthia A. Lien, MD, Matthew R. Belmont, MD, John J. Savarese, MD

Anesthesiology. September 2000: 93(3A):A–1039

https://doi.org/10.1097/00000542-200009001-01039

Published: September 2000

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Articles

Pharmacodynamics and the Plasma Concentration of Mivacurium during Spontaneous Recovery and Neostigmine-facilitated Recovery

Cynthia A. Lien, MD, Matthew R. Belmont, MD, Doreen L. Wray Roth, MD, Michiko Okamoto, PhD, Amy Abalos, RN, John J. Savarese, MD

Anesthesiology. July 1999: 91(1):119–126

https://doi.org/10.1097/00000542-199907000-00019

Published: July 1999

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Articles

Comparative Pharmacology of Cisatracurium (51W89), Atracurium, and Five Isomers in Cats

William B. Wastila, PhD, Robert B. Maehr, BS, Geoffrey L. Turner, PhD., Derek A. Hill, M. Phil., John J. Savarese, MD

Anesthesiology. July 1996: 85(1):169–177

https://doi.org/10.1097/00000542-199607000-00023

Published: July 1996

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Articles

Antagonism of Residual Mivacurium Blockade: Setting the Record Straight

John J. Savarese, MD, Cynthia A. Lien, MD, Matthew R. Belmont, MD

Anesthesiology. June 1996: 84(6):1525–1527

https://doi.org/10.1097/00000542-199606000-00045

Published: June 1996

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Articles

Pharmacokinetics of Cisatracurium in Patients Receiving Nitrous Oxide/Opioid/Barbiturate Anesthesia

Cynthia A. Lien, MD, Virginia D. Schmith, PhD, Matthew R. Belmont, MD, Amy Abalos, RN, David F. Kisor, PharmD, John J. Savarese, MD

Anesthesiology. February 1996: 84(2):300–308.

https://doi.org/10.1097/00000542-199602000-00007

Published: February 1996

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Articles

The Clinical Neuromuscular Pharmacology of 51W89 in Patients Receiving Nitrous Oxide/Opioid/Barbiturate Anesthesia

Matthew R. Belmont, MD, Cynthia A. Lien, MD, Steve Quessy, PhD, Martha M. Abou-Donia, PhD, Amy Abalos, RN, Larissa Eppich, BS, John J. Savarese, MD

Anesthesiology. May 1995: 82(5):1139–1145

https://doi.org/10.1097/00000542-199505000-00008

Published: May 1995

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Articles

The Cardiovascular Effects and Histamine-releasing Properties of 51W89 in Patients Receiving Nitrous Oxide/Opioid/Barbiturate Anesthesia

Cynthia A. Lien, MD, Matthew R. Belmont, MD, Amy Abalos, RN, Larissa Eppich, BS, Steve Quessy, PhD, Martha M. Abou-Donia, PhD, John J. Savarese, MD

Anesthesiology. May 1995: 82(5):1131–1138

https://doi.org/10.1097/00000542-199505000-00007

Published: May 1995

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Articles

The Phamtacokinetics and Pharmacodynamics of the Stereoisomers of Mivacurium in Patients Receiving Nitrous Oxide/Opioid/Barbiturate Anesthesia

Cynthia A. Lien, M.D., Virginia D. Schmith, Ph.D., Patricia B. Embree, C.R.N.A., Matthew R. Belmont, M.D., William A. Wargin, Ph.D., John J. Savarese, M.D.

Anesthesiology. June 1994: 80(6):1296–1302

https://doi.org/10.1097/00000542-199406000-00017

Published: June 1994

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NARROW

Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine

Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers

Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man

Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine—Additional Studies of Safety and Efficacy in the Anesthetized Rhesus Monkey and Cat

Rapid Chemical Antagonism of Neuromuscular Blockade by l-Cysteine Adduction to and Inactivation of the Olefinic (Double-bonded) Isoquinolinium Diester Compounds Gantacurium (AV430A), CW 002, and CW 011

Gantacurium and CW002 Do Not Potentiate Muscarinic Receptor-mediated Airway Smooth Muscle Constriction in Guinea Pigs

Cysteine Reversal of the Novel Neuromuscular Blocking Drug CW002 in Dogs: Pharmacodynamics, Acute Cardiovascular Effects, and Preliminary Toxicology

Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs

GW280430A: Pharmacodynamics and Potential Adverse Effects

Cardiopulmonary Effects of the Novel Neuromuscular Blocking Drug GW280430A (AV430A) in Dogs

Clinical Pharmacology of GW280430A in Humans

Preclinical Pharmacology of GW280430A (AV430A) in the Rhesus Monkey and in the Cat: A Comparison with Mivacurium

Room 224-226, 10/16/2000 9: 00 AM - 10: 30 AM (PD) Early Antagonism of Neuromuscular Block: Is It Effective? : A-1039

Pharmacodynamics and the Plasma Concentration of Mivacurium during Spontaneous Recovery and Neostigmine-facilitated Recovery

Comparative Pharmacology of Cisatracurium (51W89), Atracurium, and Five Isomers in Cats

Antagonism of Residual Mivacurium Blockade: Setting the Record Straight

Pharmacokinetics of Cisatracurium in Patients Receiving Nitrous Oxide/Opioid/Barbiturate Anesthesia

The Clinical Neuromuscular Pharmacology of 51W89 in Patients Receiving Nitrous Oxide/Opioid/Barbiturate Anesthesia

The Cardiovascular Effects and Histamine-releasing Properties of 51W89 in Patients Receiving Nitrous Oxide/Opioid/Barbiturate Anesthesia

The Phamtacokinetics and Pharmacodynamics of the Stereoisomers of Mivacurium in Patients Receiving Nitrous Oxide/Opioid/Barbiturate Anesthesia

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