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Michel M. R. F. Struys
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Articles

Target-controlled Infusion of Remimazolam in Healthy Volunteers Shows Some Acute Tolerance

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Remco Vellinga, M.D., Jeroen V. Koomen, Ph.D., Douglas J. Eleveld, Ph.D., Thomas Stöhr, Ph.D., Marija Pesic, Ph.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A., Pieter J. Colin, Ph.D.
Publication: Anesthesiology
Anesthesiology. February 2024: 140(2):207–219
https://doi.org/10.1097/ALN.0000000000004811
Published: February 2024
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Immune Modulatory Effects of Nonsteroidal Anti-inflammatory Drugs in the Perioperative Period and Their Consequence on Postoperative Outcome

Dirk J. Bosch, M.D., Ph.D., Gertrude J. Nieuwenhuijs-Moeke, M.D., Ph.D., Matijs van Meurs, M.D., Ph.D., Wayel H. Abdulahad, Ph.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A.
Publication: Anesthesiology
Anesthesiology. May 2022: 136(5):843–860
https://doi.org/10.1097/ALN.0000000000004141
Published: May 2022
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Allometric Scaling in Pharmacokinetic Studies in Anesthesiology

Douglas J. Eleveld, Ph.D., Jeroen V. Koomen, Ph.D., Anthony R. Absalom, M.B.Ch.B., F.R.C.A., M.D., Hong Su, M.Sc., Laura N. Hannivoort, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A.
Publication: Anesthesiology
Anesthesiology. April 2022: 136(4):609–617
https://doi.org/10.1097/ALN.0000000000004115
Published: April 2022
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Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics

Ricardo Alvarez-Jimenez, M.D., Ph.D., Maud A. S. Weerink, M.D., Laura N. Hannivoort, M.D., Ph.D., Hong Su, Pharm.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A., Stephan A. Loer, M.D., Ph.D., Pieter J. Colin, Pharm.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. February 2022: 136(2):279–292
https://doi.org/10.1097/ALN.0000000000004049
Published: February 2022
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Environmental Footprint of Anesthesia: More than Inhaled Anesthetics!

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Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A., Matthew J. Eckelman, Ph.D.
Publication: Anesthesiology
Anesthesiology. December 2021: 135(6):937–939
https://doi.org/10.1097/ALN.0000000000004050
Published: December 2021
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Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700

Beatrijs I. Valk, M.D., Douglas J. Eleveld, Ph.D., Peter Meyer, M.D., Ph.D., Sascha Meier, M.D., Ph.D., Izaak den Daas, Ph.D., Kai van Amsterdam, M.Sc., Jason A. Campagna, M.D., Ph.D., Steven P. Sweeney, B.Sc., Anthony R. Absalom, M.B.Ch.B., F.R.C.A., M.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A.
Publication: Anesthesiology
Anesthesiology. January 2021: 134(1):35–51
https://doi.org/10.1097/ALN.0000000000003590
Published: January 2021
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Meta-analysis of Ketamine Pharmacokinetics: Lots of Work Done but Still Lots to Do

Douglas J. Eleveld, Ph.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A.
Publication: Anesthesiology
Anesthesiology. December 2020: 133(6):1167–1169
https://doi.org/10.1097/ALN.0000000000003593
Published: December 2020
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Population Pharmacodynamics of Propofol and Sevoflurane in Healthy Volunteers Using a Clinical Score and the Patient State Index: A Crossover Study

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Merel H. Kuizenga, M.D., Pieter J. Colin, Ph.D., Koen M. E. M. Reyntjens, M.D., Daan J. Touw, Ph.D., Hasan Nalbat, R.N., Froukje H. Knotnerus, R.N., Hugo E. M. Vereecke, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. December 2019: 131(6):1223–1238
https://doi.org/10.1097/ALN.0000000000002966
Published: December 2019
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Pharmacodynamic Interaction of Remifentanil and Dexmedetomidine on Depth of Sedation and Tolerance of Laryngoscopy

Maud A. S. Weerink, M.D., Clemens R. M. Barends, M.D., Ernesto R. R. Muskiet, M.D., Koen M. E. M. Reyntjens, M.D., Froukje H. Knotnerus, R.N., Martine Oostra, R.N., Jan F. P. van Bocxlaer, Pharm.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A., Pieter J. Colin, Pharm.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. November 2019: 131(5):1004–1017
https://doi.org/10.1097/ALN.0000000000002882
Published: November 2019
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Pharmacokinetic Pharmacodynamic Perspective on the Detection of Signs of Neural Inertia in Humans

Pieter J. Colin, Pharm.D., Ph.D., Merel H. Kuizenga, M.D., Hugo E. M. Vereecke, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. August 2018: 129(2):373–375
https://doi.org/10.1097/ALN.0000000000002287
Published: August 2018
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A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics–Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a Single Ascending Bolus Dose

Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A., Beatrijs I. Valk, B.Sc., Douglas J. Eleveld, Ph.D., Anthony R. Absalom, M.B.Ch.B., F.R.C.A., M.D., Peter Meyer, M.D., Ph.D., Sascha Meier, M.D., Ph.D., Izaak den Daas, Ph.D., Thomas Chou, Ph.D., Kai van Amsterdam, M.Sc., Jason A. Campagna, M.D., Ph.D., Steven P. Sweeney, B.Sc.
Publication: Anesthesiology
Anesthesiology. July 2017: 127(1):20–35
https://doi.org/10.1097/ALN.0000000000001662
Published: July 2017
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An Allometric Model of Remifentanil Pharmacokinetics and Pharmacodynamics

Douglas J. Eleveld, Ph.D., Johannes H. Proost, Pharm.D., Hugo Vereecke, M.D., Ph.D., Anthony R. Absalom, M.D., Ph.D., Erik Olofsen, M.Sc., Jaap Vuyk, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. June 2017: 126(6):1005–1018
https://doi.org/10.1097/ALN.0000000000001634
Published: June 2017
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Not Really Triple Low?

Rik Carette, M.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A. (Hon), André M. De Wolf, M.D., Jan F. A. Hendrickx, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. June 2016: 124(6):1410–1411
https://doi.org/10.1097/ALN.0000000000001087
Published: June 2016
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Development of an Optimized Pharmacokinetic Model of Dexmedetomidine Using Target-controlled Infusion in Healthy Volunteers

Laura N. Hannivoort, M.D., Douglas J. Eleveld, Ph.D., Johannes H. Proost, Pharm.D., Ph.D., Koen M. E. M. Reyntjens, M.D., Anthony R. Absalom, M.B.Ch.B., M.D., Hugo E. M. Vereecke, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. August 2015: 123(2):357–367
https://doi.org/10.1097/ALN.0000000000000740
Published: August 2015
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A Response Surface Model Approach for Continuous Measures of Hypnotic and Analgesic Effect during Sevoflurane–Remifentanil Interaction: Quantifying the Pharmacodynamic Shift Evoked by Stimulation

Bjorn Heyse, M.D., Johannes H. Proost, Pharm.D., Ph.D., Laura N. Hannivoort, M.D., Douglas J. Eleveld, Ph.D., Martin Luginbühl, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D., Hugo E. M. Vereecke, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. June 2014: 120(6):1390–1399
https://doi.org/10.1097/ALN.0000000000000180
Published: June 2014
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Interaction between Nitrous Oxide, Sevoflurane, and Opioids: A Response Surface Approach

Hugo E. M. Vereecke, M.D., Ph.D., Johannes H. Proost, Pharm.D., Ph.D., Bjorn Heyse, M.D., Douglas J. Eleveld, Ph.D., Takasumi Katoh, M.D., Martin Luginbühl, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. April 2013: 118(4):894–902
https://doi.org/10.1097/ALN.0b013e3182860486
Published: April 2013
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A 28-year-old Man with Air in the Mediastinal Space after a Car Accident

Martijn Brakman, M.D., K. Tim Buddingh, M.D., Marije Smit, M.D., Michel M. R. F. Struys, M.D., Ph.D., Jan G. Zijlstra, M.D., Ph.D., Matijs van Meurs, M.D., Ph.D., Hugh C. Hemmings, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. October 2012: 117(4):878
https://doi.org/10.1097/ALN.0b013e318250bb3c
Published: October 2012
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Sevoflurane Remifentanil Interaction: Comparison of Different Response Surface Models

Bjorn Heyse, M.D., Johannes H. Proost, Pharm.D., Ph.D., Peter M. Schumacher, M.Sc., Ph.D., Thomas W. Bouillon, P.D. Dr. med., Hugo E. M. Vereecke, M.D., Ph.D., Douglas J. Eleveld, Ph.D., Martin Luginbühl, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. February 2012: 116(2):311–323
https://doi.org/10.1097/ALN.0b013e318242a2ec
Published: February 2012
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An Evaluation of Using Population Pharmacokinetic Models to Estimate Pharmacodynamic Parameters for Propofol and Bispectral Index in Children

Marc J. Coppens, M.D., Douglas J. Eleveld, Ph.D., Johannes H. Proost, Pharm.D., Ph.D., Luc A. M. Marks, D.D.S., Ph.D., Jan F. P. Van Bocxlaer, Pharm.D., Ph.D., Hugo Vereecke, M.D., Ph.D., Anthony R. Absalom, M.D., Michel M. R. F. Struys, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. July 2011: 115(1):83–93
https://doi.org/10.1097/ALN.0b013e31821a8d80
Published: July 2011
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Propofol and Remifentanil Differentially Modulate Frontal Electroencephalographic Activity

David T. J. Liley, M.B., Ch.B., Ph.D., Nicholas C. Sinclair, B.Sc. (Medical Biophysics), B.E. (Electrical and Electronic) (Hons), Tarmo Lipping, Dr.Tech., Bjorn Heyse, M.D., Hugo E. M. Vereecke, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. August 2010: 113(2):292–304
https://doi.org/10.1097/ALN.0b013e3181e3d8a6
Published: August 2010
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