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Articles

Structural Comparisons of Ligand-gated Ion Channels in Open, Closed, and Desensitized States Identify a Novel Propofol-binding Site on Mammalian γ-Aminobutyric Acid Type A Receptors

Nicholas P. Franks, F.R.C.A., F.Med.Sci., F.R.S.

Anesthesiology. April 2015: 122(4):787–794

https://doi.org/10.1097/ALN.0000000000000588

Published: April 2015

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Articles

Neuroprotection against Traumatic Brain Injury by Xenon, but Not Argon, Is Mediated by Inhibition at the N -Methyl-d-Aspartate Receptor Glycine Site

Katie Harris, B.Sc., Scott P. Armstrong, M.Sc., Rita Campos-Pires, M.D., Louise Kiru, M.Res., Nicholas P. Franks, F.R.C.A., F.Med.Sci., F.R.S., Robert Dickinson, Ph.D.

Anesthesiology. November 2013: 119(5):1137–1148

https://doi.org/10.1097/ALN.0b013e3182a2a265

Published: November 2013

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Articles

Xenon Neuroprotection in Experimental Stroke: Interactions with Hypothermia and Intracerebral Hemorrhage

Siyuan P. Sheng, Beilei Lei, M.D., Ph.D., Michael L. James, M.D., Christopher D. Lascola, M.D., Ph.D., Talaignair N. Venkatraman, Ph.D., Jin Yong Jung, M.D., Ph.D., Mervyn Maze, M.B., Ch.B., Nicholas P. Franks, Ph.D., Robert D. Pearlstein, Ph.D., Huaxin Sheng, M.D., David S. Warner, M.D.

Anesthesiology. December 2012: 117(6):1262–1275

https://doi.org/10.1097/ALN.0b013e3182746b81

Published: December 2012

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Articles

Identification of Two Mutations (F758W and F758Y) in the N -methyl-D-aspartate Receptor Glycine-binding Site that Selectively Prevent Competitive Inhibition by Xenon without Affecting Glycine Binding

Scott P. Armstrong, M.Sc., Paul J. Banks, Ph.D., Thomas J. W. McKitrick, B.Sc., Catharine H. Geldart, B.Sc., Christopher J. Edge, Ph.D., F.R.C.A., Rohan Babla, B.Sc., Constantinos Simillis, B.Sc., M.B.B.S., Nicholas P. Franks, Ph.D., F.R.S., F.R.C.A., F.Med.Sci., Robert Dickinson, Ph.D.

Anesthesiology. July 2012: 117(1):38–47

https://doi.org/10.1097/ALN.0b013e31825ada2e

Published: July 2012

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Articles

Competitive Inhibition at the Glycine Site of the N -Methyl-d-Aspartate Receptor Mediates Xenon Neuroprotection against Hypoxia–Ischemia

Paul Banks, B.Sc., Nicholas P. Franks, Ph.D., F.R.C.A., F.Med.Sci., Robert Dickinson, Ph.D.

Anesthesiology. March 2010: 112(3):614–622

https://doi.org/10.1097/ALN.0b013e3181cea398

Published: March 2010

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Articles

General Anesthesia and Ascending Arousal Pathways

Anna Y. Zecharia, Ph.D., Nicholas P. Franks, Ph.D., F.R.C.A., F.Med.Sci.

Anesthesiology. October 2009: 111(4):695–696

https://doi.org/10.1097/ALN.0b013e3181b061bc

Published: October 2009

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Articles

Competitive Inhibition at the Glycine Site of the N -Methyl-d-aspartate Receptor by the Anesthetics Xenon and Isoflurane: Evidence from Molecular Modeling and Electrophysiology

Robert Dickinson, Ph.D., Brian K. Peterson, Ph.D., Paul Banks, B.Sc., Constantinos Simillis, M.B., B.S., Juan Carlos Sacristan Martin, B.Sc., Carlos A. Valenzuela, Ph.D., Mervyn Maze, M.B., Ch.B., Nicholas P. Franks, Ph.D.

Anesthesiology. November 2007: 107(5):756–767

https://doi.org/10.1097/01.anes.0000287061.77674.71

Published: November 2007

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Articles

Xenon Mitigates Isoflurane-induced Neuronal Apoptosis in the Developing Rodent Brain

Daqing Ma, M.D., Ph.D., Peter Williamson, M.B., B.S., Adam Januszewski, B.Sc., Marie-Caroline Nogaro, B.Sc., Mahmuda Hossain, Ph.D., Lay Ping Ong, Yi Shu, BSc., Nicholas P. Franks, Ph.D., F.Med.Sci., Mervyn Maze, M.B., Ch.B., F.Med.Sci.

Anesthesiology. April 2007: 106(4):746–753

https://doi.org/10.1097/01.anes.0000264762.48920.80

Published: April 2007

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Articles

Air Bubble Growth in Water

Nicholas P. Franks, Ph.D., F.Med.Sci., Rodrigo Benavides, M.D., Mervyn Maze, F.R.C.P., F.R.C.A., F.Med.Sci.

Anesthesiology. November 2006: 105(5):1059–1060

https://doi.org/10.1097/00000542-200611000-00031

Published: November 2006

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Articles

Feasibility and Safety of Delivering Xenon to Patients Undergoing Coronary Artery Bypass Graft Surgery While on Cardiopulmonary Bypass: Phase I Study

Geoffrey G. Lockwood, M.B. B.S., Ph.D., Nicholas P. Franks, Ph.D., F.Med.Sci., Neil A. Downie, Ph.D., Kenneth M. Taylor, Ph.D., M.D., F.R.C.S., F.R.C.S.E., Mervyn Maze, M.B., Ch.B., F.R.C.P., F.R.C.A., F.Med.Sci.

Anesthesiology. March 2006: 104(3):458–465

https://doi.org/10.1097/00000542-200603000-00012

Published: March 2006

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Articles

Expansion of Gas Bubbles by Nitrous Oxide and Xenon

Rodrigo Benavides, M.D., Mervyn Maze, F.R.C.P., F.R.C.A., F.Med.Sci., Nicholas P. Franks, Ph.D., F.Med.Sci.

Anesthesiology. February 2006: 104(2):299–302

https://doi.org/10.1097/00000542-200602000-00015

Published: February 2006

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Articles

Neuroprotection by Nitrous Oxide and Xenon and Its Relation to Minimum Alveolar Concentration

H Mayumi Homi, M.D., Noriko Yokoo, M.D., Daqing Ma, M.D., David S. Warner, M.D., Nicholas P. Franks, Ph.D., Mervyn Maze, M.B.Ch.B., F.R.C.P., F.R.C.A., Hilary P. Grocott, M.D., F.R.C.P.C.

Anesthesiology. July 2004: 101(1):261

https://doi.org/10.1097/00000542-200407000-00050

Published: July 2004

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Articles

Seeing the Light: Protein Theories of General Anesthesia

Nicholas P. Franks, Ph.D., William R. Lieb, Ph.D., Srinivasa N. Raja, M.D.

Anesthesiology. July 2004: 101(1):235–237

https://doi.org/10.1097/00000542-200407000-00034

Published: July 2004

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Articles

Rested and Refreshed after Anesthesia? Overlapping Neurobiologic Mechanisms of Sleep and Anesthesia

Laura E. Nelson, Ph.D., Nicholas P. Franks, Ph.D., Mervyn Maze, M.B., Ch.B., F.R.C.P., F.R.C.A., F.Med.Sci.

Anesthesiology. June 2004: 100(6):1341–1342

https://doi.org/10.1097/00000542-200406000-00003

Published: June 2004

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Articles

Xenon Exerts Age-independent Antinociception in Fischer Rats

Daqing Ma, M.D., Ph.D., Robert D. Sanders, M.B.B.S., Sunil Halder, B.Sc., Nishanthan Rajakumaraswamy, B.Sc., Nicholas P. Franks, Ph.D., Mervyn Maze, F.R.C.P., F.R.C.A., F.Med.Sci.

Anesthesiology. May 2004: 100(5):1313–1318

https://doi.org/10.1097/00000542-200405000-00040

Published: May 2004

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Articles

Determinants of the Sensitivity of AMPA Receptors to Xenon

Andrew J. R. Plested, Ph.D., Scott S. Wildman, Ph.D., William R. Lieb, Ph.D., Nicholas P. Franks, Ph.D.

Anesthesiology. February 2004: 100(2):347–358

https://doi.org/10.1097/00000542-200402000-00025

Published: February 2004

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Articles

The Neuroprotective Effect of Xenon Administration during Transient Middle Cerebral Artery Occlusion in Mice

H. Mayumi Homi, M.D., Noriko Yokoo, M.D., Daqing Ma, M.D., David S. Warner, M.D., Nicholas P. Franks, Ph.D., Mervyn Maze, M.B.Ch.B., F.R.C.P., F.R.C.A., Hilary P. Grocott, M.D., F.R.C.P.C.

Anesthesiology. October 2003: 99(4):876–881

https://doi.org/10.1097/00000542-200310000-00020

Published: October 2003

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Articles

Combination of Xenon and Isoflurane Produces a Synergistic Protective Effect against Oxygen–Glucose Deprivation Injury in a Neuronal–Glial Co-culture Model

Daqing Ma, M.D., Ph.D., Mahmuda Hossain, Ph.D., Nishanthan Rajakumaraswamy, B.Sc., Nicholas P. Franks, Ph.D., Mervyn Maze, FRCP, FRCA, FMedSci

Anesthesiology. September 2003: 99(3):748–751

https://doi.org/10.1097/00000542-200309000-00034

Published: September 2003

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Articles

Xenon Attenuates Cardiopulmonary Bypass–induced Neurologic and Neurocognitive Dysfunction in the Rat

Daqing Ma, M.D., Ph.D., Hong Yang, M.D., John Lynch, M.D., Nicholas P. Franks, Ph.D., Mervyn Maze, M.B., Ch.B., F.R.C.P., F.R.C.A., Hilary P. Grocott, M.D., F.R.C.P.C.

Anesthesiology. March 2003: 98(3):690–698

https://doi.org/10.1097/00000542-200303000-00017

Published: March 2003

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Articles

The α 2 -Adrenoceptor Agonist Dexmedetomidine Converges on an Endogenous Sleep-promoting Pathway to Exert Its Sedative Effects

Laura E. Nelson, B.A., Jun Lu, M.D., Ph.D., Tianzhi Guo, M.D., Clifford B. Saper, M.D., Ph.D., Nicholas P. Franks, Ph.D., Mervyn Maze, M.B., Ch.B., F.R.C.P., F.R.C.A. F.MedSci.

Anesthesiology. February 2003: 98(2):428–436

https://doi.org/10.1097/00000542-200302000-00024

Published: February 2003

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NARROW

Structural Comparisons of Ligand-gated Ion Channels in Open, Closed, and Desensitized States Identify a Novel Propofol-binding Site on Mammalian γ-Aminobutyric Acid Type A Receptors

Neuroprotection against Traumatic Brain Injury by Xenon, but Not Argon, Is Mediated by Inhibition at the N -Methyl-d-Aspartate Receptor Glycine Site

Xenon Neuroprotection in Experimental Stroke: Interactions with Hypothermia and Intracerebral Hemorrhage

Identification of Two Mutations (F758W and F758Y) in the N -methyl-D-aspartate Receptor Glycine-binding Site that Selectively Prevent Competitive Inhibition by Xenon without Affecting Glycine Binding

Competitive Inhibition at the Glycine Site of the N -Methyl-d-Aspartate Receptor Mediates Xenon Neuroprotection against Hypoxia–Ischemia

General Anesthesia and Ascending Arousal Pathways

Competitive Inhibition at the Glycine Site of the N -Methyl-d-aspartate Receptor by the Anesthetics Xenon and Isoflurane: Evidence from Molecular Modeling and Electrophysiology

Xenon Mitigates Isoflurane-induced Neuronal Apoptosis in the Developing Rodent Brain

Air Bubble Growth in Water

Feasibility and Safety of Delivering Xenon to Patients Undergoing Coronary Artery Bypass Graft Surgery While on Cardiopulmonary Bypass: Phase I Study

Expansion of Gas Bubbles by Nitrous Oxide and Xenon

Neuroprotection by Nitrous Oxide and Xenon and Its Relation to Minimum Alveolar Concentration

Seeing the Light: Protein Theories of General Anesthesia

Rested and Refreshed after Anesthesia? Overlapping Neurobiologic Mechanisms of Sleep and Anesthesia

Xenon Exerts Age-independent Antinociception in Fischer Rats

Determinants of the Sensitivity of AMPA Receptors to Xenon

The Neuroprotective Effect of Xenon Administration during Transient Middle Cerebral Artery Occlusion in Mice

Combination of Xenon and Isoflurane Produces a Synergistic Protective Effect against Oxygen–Glucose Deprivation Injury in a Neuronal–Glial Co-culture Model

Xenon Attenuates Cardiopulmonary Bypass–induced Neurologic and Neurocognitive Dysfunction in the Rat

The α 2 -Adrenoceptor Agonist Dexmedetomidine Converges on an Endogenous Sleep-promoting Pathway to Exert Its Sedative Effects

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