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Systematized Serendipity: Fishing Expeditions for Anesthetic Drugs and Targets

C. Michael Crowder, M.D., Ph.D., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. November 2024: 141(5):997–1006

https://doi.org/10.1097/ALN.0000000000005153

Published: November 2024

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Articles

Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on γ-Aminobutyric Acid Type A Receptors

Helen Hoyt, B.S., Ryan J. Fantasia, B.S., Kieran Bhave, B.A., Xiaoxuan Yang, M.D., Ph.D., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. November 2022: 137(5):568–585

https://doi.org/10.1097/ALN.0000000000004361

Published: November 2022

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Articles

γ-Aminobutyric Acid Type A Receptor Subtypes and Circuit Connections in Midazolam-induced Amnesia, Sedation, and Hypnosis

Stuart A. Forman, M.D., Ph.D.

Anesthesiology. June 2022: 136(6):880–882

https://doi.org/10.1097/ALN.0000000000004234

Published: June 2022

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Articles

New Evidence of Receptor-based Pharmacology Underlying a Volatile Anesthetic Effect

Stuart A. Forman, M.D., Ph.D.

Anesthesiology. November 2020: 133(5):973–975

https://doi.org/10.1097/ALN.0000000000003559

Published: November 2020

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Articles

Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABA A Receptor and In Vivo Zebrafish Studies

Megan McGrath, B.S., Helen Hoyt, B.A., Andrea Pence, B.S., Selwyn S. Jayakar, Ph.D., Xiaojuan Zhou, Ph.D., Stuart A. Forman, M.D., Ph.D., Jonathan B. Cohen, Ph.D., Keith W. Miller, D.Phil., Douglas E. Raines, M.D.

Anesthesiology. September 2020: 133(3):583–594

https://doi.org/10.1097/ALN.0000000000003403

Published: September 2020

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Articles

Drug-selective Anesthetic Insensitivity of Zebrafish Lacking γ-Aminobutyric Acid Type A Receptor β3 Subunits

Xiaoxuan Yang, M.D., Ph.D., Youssef Jounaidi, Ph.D., Kusumika Mukherjee, Ph.D., Ryan J. Fantasia, B.S., Eric C. Liao, M.D., Ph.D., Buwei Yu, M.D., Ph.D., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. December 2019: 131(6):1276–1291

https://doi.org/10.1097/ALN.0000000000002963

Published: December 2019

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Articles

High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics

Xiaoxuan Yang, M.D., Youssef Jounaidi, Ph.D., Jennifer B. Dai, B.S., Francisco Marte-Oquendo, B.S., Elizabeth S. Halpin, B.S., Lauren E. Brown, Ph.D., Richard Trilles, B.A., Wenqing Xu, Ph.D., Renee Daigle, B.S., Buwei Yu, M.D., Ph.D., Scott E. Schaus, Ph.D., John A. Porco, Jr., Ph.D., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. September 2018: 129(3):459–476

https://doi.org/10.1097/ALN.0000000000002281

Published: September 2018

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Articles

Alphaxalone Binds in Inner Transmembrane β + –α − Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors

Alexis M. Ziemba, B.A., Andrea Szabo, B.S., David W. Pierce, B.S., Marian Haburcak, Ph.D., Alex T. Stern, B.S., Anahita Nourmahnad, B.S., Elizabeth S. Halpin, B.A., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. February 2018: 128(2):338–351

https://doi.org/10.1097/ALN.0000000000001978

Published: February 2018

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Articles

Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site

Anahita Nourmahnad, B.S., Alex T. Stern, B.S., Mayo Hotta, B.S., Deirdre S. Stewart, Ph.D., Alexis M. Ziemba, B.A., Andrea Szabo, B.S., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. December 2016: 125(6):1144–1158

https://doi.org/10.1097/ALN.0000000000001390

Published: December 2016

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Articles

A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors

Alex T. Stern, B.S., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. January 2016: 124(1):89–100

https://doi.org/10.1097/ALN.0000000000000934

Published: January 2016

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Articles

Research at the Harvard Anesthesia Departments

Stuart A. Forman, M.D., Ph.D., Keith W. Miller, D.Phil., Daniel Talmor, M.D., Paul Hickey, M.D., Gary Strichartz, Ph.D., Jeanine Wiener-Kronish, M.D.

Anesthesiology. December 2014: 121(6):1141–1143

https://doi.org/10.1097/ALN.0000000000000483

Published: December 2014

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Articles

In Reply

Stuart A. Forman, M.D., Ph.D.

Anesthesiology. October 2013: 119(4):996

https://doi.org/10.1097/ALN.0b013e3182a46271

Published: October 2013

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Articles

A Paradigm Shift from Biophysical to Neurobiological: The Fading Influence of Claude Bernard’s Ideas about General Anesthesia

Stuart A. Forman, M.D., Ph.D.

Anesthesiology. April 2013: 118(4):984–985

https://doi.org/10.1097/ALN.0b013e3182860777

Published: April 2013

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Articles

The Expanding Genetic Toolkit for Exploring Mechanisms of General Anesthesia

Stuart A. Forman, M.D., Ph.D.

Anesthesiology. April 2013: 118(4):769–771

https://doi.org/10.1097/ALN.0b013e318287b7e4

Published: April 2013

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Articles

Two Etomidate Sites in α1β2γ2 γ-Aminobutyric Acid Type A Receptors Contribute Equally and Noncooperatively to Modulation of Channel Gating

Grigori Guitchounts, B.A., Deirdre S. Stewart, Ph.D., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. June 2012: 116(6):1235–1244

https://doi.org/10.1097/ALN.0b013e3182567df3

Published: June 2012

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Articles

An Allosteric Coagonist Model for Propofol Effects on α1β2γ2L γ-Aminobutyric Acid Type A Receptors

Dirk Ruesch, M.D., Elena Neumann, M.D., Hinnerk Wulf, M.D., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. January 2012: 116(1):47–55

https://doi.org/10.1097/ALN.0b013e31823d0c36

Published: January 2012

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Articles

Clinical and Molecular Pharmacology of Etomidate

Stuart A. Forman, M.D., Ph.D., David S. Warner, M.D.

Anesthesiology. March 2011: 114(3):695–707

https://doi.org/10.1097/ALN.0b013e3181ff72b5

Published: March 2011

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Articles

Carboetomidate: A Pyrrole Analog of Etomidate Designed Not to Suppress Adrenocortical Function

Joseph F. Cotten, M.D., Ph.D., Stuart A. Forman, M.D., Ph.D., Joydev K. Laha, Ph.D., Gregory D. Cuny, Ph.D., S. Shaukat Husain, D.Phil., Keith W. Miller, D.Phil., Hieu H. Nguyen, B.S., Elizabeth W. Kelly, B.A., Deirdre Stewart, Ph.D., Aiping Liu, Ph.D., Douglas E. Raines, M.D.

Anesthesiology. March 2010: 112(3):637–644

https://doi.org/10.1097/ALN.0b013e3181cf40ed

Published: March 2010

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Articles

γ-Amino Butyric Acid Type A Receptor Mutations at β2N265 Alter Etomidate Efficacy While Preserving Basal and Agonist-dependent Activity

Rooma Desai, Ph.D., Dirk Ruesch, M.D., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. October 2009: 111(4):774–784

https://doi.org/10.1097/ALN.0b013e3181b55fae

Published: October 2009

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Articles

Methoxycarbonyl-etomidate: A Novel Rapidly Metabolized and Ultra–short-acting Etomidate Analogue that Does Not Produce Prolonged Adrenocortical Suppression

Joseph F. Cotten, M.D., Ph.D., S Shaukat Husain, D.Phil., Stuart A. Forman, M.D., Ph.D., Keith W. Miller, D.Phil., Elizabeth W. Kelly, B.A., Hieu H. Nguyen, B.A., Douglas E. Raines, M.D.

Anesthesiology. August 2009: 111(2):240–249

https://doi.org/10.1097/ALN.0b013e3181ae63d1

Published: August 2009

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NARROW

Systematized Serendipity: Fishing Expeditions for Anesthetic Drugs and Targets

Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on γ-Aminobutyric Acid Type A Receptors

γ-Aminobutyric Acid Type A Receptor Subtypes and Circuit Connections in Midazolam-induced Amnesia, Sedation, and Hypnosis

New Evidence of Receptor-based Pharmacology Underlying a Volatile Anesthetic Effect

Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABA A Receptor and In Vivo Zebrafish Studies

Drug-selective Anesthetic Insensitivity of Zebrafish Lacking γ-Aminobutyric Acid Type A Receptor β3 Subunits

High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics

Alphaxalone Binds in Inner Transmembrane β + –α − Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors

Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site

A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors

Research at the Harvard Anesthesia Departments

In Reply

A Paradigm Shift from Biophysical to Neurobiological: The Fading Influence of Claude Bernard’s Ideas about General Anesthesia

The Expanding Genetic Toolkit for Exploring Mechanisms of General Anesthesia

Two Etomidate Sites in α1β2γ2 γ-Aminobutyric Acid Type A Receptors Contribute Equally and Noncooperatively to Modulation of Channel Gating

An Allosteric Coagonist Model for Propofol Effects on α1β2γ2L γ-Aminobutyric Acid Type A Receptors

Clinical and Molecular Pharmacology of Etomidate

Carboetomidate: A Pyrrole Analog of Etomidate Designed Not to Suppress Adrenocortical Function

γ-Amino Butyric Acid Type A Receptor Mutations at β2N265 Alter Etomidate Efficacy While Preserving Basal and Agonist-dependent Activity

Methoxycarbonyl-etomidate: A Novel Rapidly Metabolized and Ultra–short-acting Etomidate Analogue that Does Not Produce Prolonged Adrenocortical Suppression

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