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Articles

Area under the Plasma Concentration–Time Curve of Inorganic Fluoride following Sevoflurane Anesthesia Correlates with CYP2E1 mRNA Level in Mononuclear Cells

Ichiro Hase, M.D., Susumu Imaoka, Ph.D., Yutaka Oda, M.D., Toyoko Hiroi, D.V.M., Tatsuo Nakamoto, M.D., Akira Asada, M.D., Yoshihiko Funae, Ph.D.
Publication: Anesthesiology
Anesthesiology. June 2000: 92(6):1661–1666
https://doi.org/10.1097/00000542-200006000-00025
Published: June 2000
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Articles

Clinical Isoflurane Metabolism by Cytochrome P450 2E1

Evan D. Kharasch, MD, PhD, Douglas C. Hankins, MA, Kathy Cox, BS
Publication: Anesthesiology
Anesthesiology. March 1999: 90(3):766–771
https://doi.org/10.1097/00000542-199903000-00019
Published: March 1999
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Clinical Sevoflurane Metabolism and Disposition: II. The Role of Cytochrome P450 2E1 in Fluoride and Hexafluoroisopropanol Formation

Evan D. Kharasch, MD, PhD, Andrew S. Armstrong, MBBS, FANZCA, Kerry Gunn, MBChB, FANZCA, Alan Artru, MD, Kathy Cox, BS, Michael D. Karol, PhD
Publication: Anesthesiology
Anesthesiology. June 1995: 82(6):1379–1388.
https://doi.org/10.1097/00000542-199506000-00009
Published: June 1995
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Identification of Cytochrome P450 2E1 as the Predominant Enzyme Catalyzing Human Liver Microsomal Defluorination of Sevoflurane, Isoflurane, and Methoxyflurane

Evan D. Kharasch, M.D. Ph.D., Kenneth E. Thummel, Ph.D.
Publication: Anesthesiology
Anesthesiology. October 1993: 79(4):795–807
https://doi.org/10.1097/00000542-199310000-00023
Published: October 1993
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