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Understanding Potential Drug Side Effects: Can We Translate Molecular Mechanisms to Clinical Applications?

Andreas Koster, M.D., Jerrold H. Levy, M.D., F.A.H.A., F.C.C.M.

Anesthesiology. July 2017: 127(1):6–8

https://doi.org/10.1097/ALN.0000000000001666

Published: July 2017

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Articles

High Concentrations of Tranexamic Acid Inhibit Ionotropic Glutamate Receptors

Irene Lecker, Ph.D., Dian-Shi Wang, M.D., Ph.D., Kirusanthy Kaneshwaran, B.S., C. David Mazer, M.D., Beverley A. Orser, M.D., Ph.D.

Anesthesiology. July 2017: 127(1):89–97

https://doi.org/10.1097/ALN.0000000000001665

Published: July 2017

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Articles

Long-term Application of Glycine Transporter Inhibitors Acts Antineuropathic and Modulates Spinal N -methyl-d-aspartate Receptor Subunit NR-1 Expression in Rats

Franziska Barthel, V.M.D., Andrea Urban, V.M.D., Lukas Schlösser, M.D., Volker Eulenburg, Ph.D., Robert Werdehausen, M.D., Timo Brandenburger, M.D., Carmen Aragon, Ph.D., Inge Bauer, Ph.D., Henning Hermanns, M.D.

Anesthesiology. July 2014: 121(1):160–169

https://doi.org/10.1097/ALN.0000000000000203

Published: July 2014

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Articles

Neuroprotection against Traumatic Brain Injury by Xenon, but Not Argon, Is Mediated by Inhibition at the N -Methyl-d-Aspartate Receptor Glycine Site

Katie Harris, B.Sc., Scott P. Armstrong, M.Sc., Rita Campos-Pires, M.D., Louise Kiru, M.Res., Nicholas P. Franks, F.R.C.A., F.Med.Sci., F.R.S., Robert Dickinson, Ph.D.

Anesthesiology. November 2013: 119(5):1137–1148

https://doi.org/10.1097/ALN.0b013e3182a2a265

Published: November 2013

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Articles

Mutations M287L and Q266I in the Glycine Receptor α1 Subunit Change Sensitivity to Volatile Anesthetics in Oocytes and Neurons, but Not the Minimal Alveolar Concentration in Knockin Mice

Cecilia M. Borghese, Ph.D., Wei Xiong, Ph.D., S. Irene Oh, B.S., Angel Ho, B.S., S. John Mihic, Ph.D., Li Zhang, M.D., David M. Lovinger, Ph.D., Gregg E. Homanics, Ph.D., Edmond I. Eger, M.D., R. Adron Harris, Ph.D.

Anesthesiology. October 2012: 117(4):765–771

https://doi.org/10.1097/ALN.0b013e31826a0d93

Published: October 2012

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Articles

Identification of Two Mutations (F758W and F758Y) in the N -methyl-D-aspartate Receptor Glycine-binding Site that Selectively Prevent Competitive Inhibition by Xenon without Affecting Glycine Binding

Scott P. Armstrong, M.Sc., Paul J. Banks, Ph.D., Thomas J. W. McKitrick, B.Sc., Catharine H. Geldart, B.Sc., Christopher J. Edge, Ph.D., F.R.C.A., Rohan Babla, B.Sc., Constantinos Simillis, B.Sc., M.B.B.S., Nicholas P. Franks, Ph.D., F.R.S., F.R.C.A., F.Med.Sci., Robert Dickinson, Ph.D.

Anesthesiology. July 2012: 117(1):38–47

https://doi.org/10.1097/ALN.0b013e31825ada2e

Published: July 2012

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Articles

Lidocaine Metabolites Inhibit Glycine Transporter 1: A Novel Mechanism for the Analgesic Action of Systemic Lidocaine?

Robert Werdehausen, M.D., David Kremer, M.D., Timo Brandenburger, M.D., Lukas Schlösser, M.D., Janusz Jadasz, M.Sc., Patrick Küry, Ph.D., Inge Bauer, Ph.D., Carmen Aragón, Ph.D., Volker Eulenburg, Ph.D., Henning Hermanns, M.D.

Anesthesiology. January 2012: 116(1):147–158

https://doi.org/10.1097/ALN.0b013e31823cf233

Published: January 2012

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Articles

Competitive Inhibition at the Glycine Site of the N -Methyl-d-Aspartate Receptor Mediates Xenon Neuroprotection against Hypoxia–Ischemia

Paul Banks, B.Sc., Nicholas P. Franks, Ph.D., F.R.C.A., F.Med.Sci., Robert Dickinson, Ph.D.

Anesthesiology. March 2010: 112(3):614–622

https://doi.org/10.1097/ALN.0b013e3181cea398

Published: March 2010

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Articles

Glycine Transporter Inhibitors as a Potential Therapeutic Strategy for Chronic Pain with Memory Impairment

Mitsuo Tanabe, Ph.D., Keiko Takasu, Ph.D., Sachiko Yamaguchi, M.Pharm.Sci., Daisuke Kodama, M.Pharm.Sci., Hideki Ono, Ph.D.

Anesthesiology. May 2008: 108(5):929–937

https://doi.org/10.1097/ALN.0b013e31816c9044

Published: May 2008

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Articles

Nonhalogenated Alkanes Cyclopropane and Butane Affect Neurotransmitter-gated Ion Channel and G-protein–coupled Receptors: Differential Actions on GABAAand Glycine Receptors

Koji Hara, M.D., Ph.D., Edmond I. Eger, M.D., Michael J. Laster, D.V.M., R. Adron Harris, Ph.D.

Anesthesiology. December 2002: 97(6):1512–1520

https://doi.org/10.1097/00000542-200212000-00025

Published: December 2002

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Articles

Divergence of Volatile Anesthetic Effects in Inhibitory Neurotransmitter Receptors

Eric P. Greenblatt, M.D., Xin Meng, M.D.

Anesthesiology. June 2001: 94(6):1026–1033

https://doi.org/10.1097/00000542-200106000-00017

Published: June 2001

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Articles

Room D, 10/17/2000 2: 00 PM - 4: 00 PM (PS) Spinal GABA A and Glycine Systems Cooperatively Mediate Halothane Depression of Spinal Dorsal Horn Neurons in Rats : A-804

M. Yamauchi, M.D., H. Sekiyama, M.D., S. G. Shimada, Ph.D., J. G. Collins, Ph.D.

Anesthesiology. September 2000: 93(3A):A–804

https://doi.org/10.1097/00000542-200009001-00804

Published: September 2000

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Articles

Continuous Intrathecal Administration of Short-lasting micro Opioids Remifentanil and Alfentanil in the Rat

Hartmut Buerkle, MD, Tony L. Yaksh, PhD

Anesthesiology. April 1996: 84(4):926–935.

https://doi.org/10.1097/00000542-199604000-00021

Published: April 1996

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Articles

Masseter Muscle Rigidity Associated with Glycine 1306 -to- Alanine Mutation in the Adult Muscle Sodium Channel α-Subunit Gene

Gary M. Vita, MD, Antonel Olckers, MSc, Anne E. Jedlicka, BSc, Alfred L. George, MD, Terry Heiman-Patterson, MD, Henry Rosenberg, MD, Jeffrey E. Fletcher, PhD, Roy C. Levitt, MD

Anesthesiology. May 1995: 82(5):1097–1103

https://doi.org/10.1097/00000542-199505000-00002

Published: May 1995

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Articles

Isoflurane Reduces Ischemia-induced Glutamate Release in Rats Subjected to Forebrain Ischemia

Piyush M. Patel, MD, FRCPC, John C. Drummond, MD, FRCPC, Daniel J. Cole, MD, Randall L. Goskowicz, MD

Anesthesiology. April 1995: 82(4):996–1003.

https://doi.org/10.1097/00000542-199504000-00024

Published: April 1995

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Articles

Effects of Hypothermia or Anesthetics on Hippocampal Glutamate and Glycine Concentrations after Repeated Transient Global Cerebral Ischemia

Udo M. Illievich, M.D., Mark H. Zornow, M.D., Kyu Taek Choi, M.D., Martin A. P. Strnat, M.S., Mark S. Scheller, M.D.

Anesthesiology. January 1994: 80(1):177–186

https://doi.org/10.1097/00000542-199401000-00025

Published: January 1994

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Articles

Transurethral Resection of the Prostate, Serum Glycine Levels, and Ocular Evoked Potentials

Janice Mel-Li Wang, M.D., Donnell J. Creel, Ph.D., K. C. Wong, M.D., Ph.D.

Anesthesiology. January 1989: 70(1):36–41

https://doi.org/10.1097/00000542-198901000-00009

Published: January 1989

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Articles

Ammonia Toxicity Resulting from Glycine Absorption during a Transurethral Resection of the Prostate

RYLAND P. ROESCH, M.D., ROBERT K. STOELTING, M.D., JAMES E. LINGEMAN, M.D., RICHARD J. KAHNOSKI, M.D., DAVID J. BACKES, M.D., STEPHEN A. GEPHARDT, M.D.

Anesthesiology. June 1983: 58(6):577–578

https://doi.org/10.1097/00000542-198306000-00021

Published: June 1983

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Articles

Acute Water Intoxication during Transurethral Resection of the Prostate, Using Glycine Solution for Irrigation

James A. Still, M.D., Jerome H. Modell, M.D.

Anesthesiology. January 1973: 38(1):98–99

https://doi.org/10.1097/00000542-197301000-00026

Published: January 1973

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NARROW

Understanding Potential Drug Side Effects: Can We Translate Molecular Mechanisms to Clinical Applications?

High Concentrations of Tranexamic Acid Inhibit Ionotropic Glutamate Receptors

Long-term Application of Glycine Transporter Inhibitors Acts Antineuropathic and Modulates Spinal N -methyl-d-aspartate Receptor Subunit NR-1 Expression in Rats

Neuroprotection against Traumatic Brain Injury by Xenon, but Not Argon, Is Mediated by Inhibition at the N -Methyl-d-Aspartate Receptor Glycine Site

Mutations M287L and Q266I in the Glycine Receptor α1 Subunit Change Sensitivity to Volatile Anesthetics in Oocytes and Neurons, but Not the Minimal Alveolar Concentration in Knockin Mice

Identification of Two Mutations (F758W and F758Y) in the N -methyl-D-aspartate Receptor Glycine-binding Site that Selectively Prevent Competitive Inhibition by Xenon without Affecting Glycine Binding

Lidocaine Metabolites Inhibit Glycine Transporter 1: A Novel Mechanism for the Analgesic Action of Systemic Lidocaine?

Competitive Inhibition at the Glycine Site of the N -Methyl-d-Aspartate Receptor Mediates Xenon Neuroprotection against Hypoxia–Ischemia

Glycine Transporter Inhibitors as a Potential Therapeutic Strategy for Chronic Pain with Memory Impairment

Nonhalogenated Alkanes Cyclopropane and Butane Affect Neurotransmitter-gated Ion Channel and G-protein–coupled Receptors: Differential Actions on GABAAand Glycine Receptors

Divergence of Volatile Anesthetic Effects in Inhibitory Neurotransmitter Receptors

Room D, 10/17/2000 2: 00 PM - 4: 00 PM (PS) Spinal GABA A and Glycine Systems Cooperatively Mediate Halothane Depression of Spinal Dorsal Horn Neurons in Rats : A-804

Continuous Intrathecal Administration of Short-lasting micro Opioids Remifentanil and Alfentanil in the Rat

Masseter Muscle Rigidity Associated with Glycine 1306 -to- Alanine Mutation in the Adult Muscle Sodium Channel α-Subunit Gene

Isoflurane Reduces Ischemia-induced Glutamate Release in Rats Subjected to Forebrain Ischemia

Effects of Hypothermia or Anesthetics on Hippocampal Glutamate and Glycine Concentrations after Repeated Transient Global Cerebral Ischemia

Transurethral Resection of the Prostate, Serum Glycine Levels, and Ocular Evoked Potentials

Ammonia Toxicity Resulting from Glycine Absorption during a Transurethral Resection of the Prostate

Acute Water Intoxication during Transurethral Resection of the Prostate, Using Glycine Solution for Irrigation

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