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Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on γ-Aminobutyric Acid Type A Receptors

Helen Hoyt, B.S., Ryan J. Fantasia, B.S., Kieran Bhave, B.A., Xiaoxuan Yang, M.D., Ph.D., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. November 2022: 137(5):568–585

https://doi.org/10.1097/ALN.0000000000004361

Published: November 2022

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Articles

Anesthesia Mechanisms: A Patchwork Quilt rather than a Wet Blanket?

Logan Voss, Ph.D., Jamie W. Sleigh, M.D.

Anesthesiology. October 2021: 135(4):568–569

https://doi.org/10.1097/ALN.0000000000003879

Published: October 2021

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Articles

High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics

Xiaoxuan Yang, M.D., Youssef Jounaidi, Ph.D., Jennifer B. Dai, B.S., Francisco Marte-Oquendo, B.S., Elizabeth S. Halpin, B.S., Lauren E. Brown, Ph.D., Richard Trilles, B.A., Wenqing Xu, Ph.D., Renee Daigle, B.S., Buwei Yu, M.D., Ph.D., Scott E. Schaus, Ph.D., John A. Porco, Jr., Ph.D., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. September 2018: 129(3):459–476

https://doi.org/10.1097/ALN.0000000000002281

Published: September 2018

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Articles

Gone Fishing…

Roderic G. Eckenhoff, M.D.

Anesthesiology. September 2018: 129(3):392–393

https://doi.org/10.1097/ALN.0000000000002328

Published: September 2018

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Articles

Does Equi–Minimum Alveolar Concentration Value Ensure Equivalent Analgesic or Hypnotic Potency?: A Comparison between Desflurane and Sevoflurane

Kyoung-Ho Ryu, M.D., Keulame Song, M.D., Tae-Young Lim, M.D., Won-Jun Choi, M.D., Ph.D., Yun-Hong Kim, M.D., Ph.D., Hyun-Soo Kim, M.D., Ph.D.

Anesthesiology. June 2018: 128(6):1092–1098

https://doi.org/10.1097/ALN.0000000000002158

Published: June 2018

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Articles

Cyclopropyl-methoxycarbonyl Metomidate: Studies in a Lipopolysaccharide Inflammatory Model of Sepsis

Peter Santer, M.D., Ervin Pejo, B.S., Yan Feng, M.D., Ph.D., Wei Chao, M.D., Ph.D., Douglas E. Raines, M.D.

Anesthesiology. August 2015: 123(2):368–376

https://doi.org/10.1097/ALN.0000000000000721

Published: August 2015

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Articles

Analogues of Etomidate: Modifications around Etomidate’s Chiral Carbon and the Impact on In Vitro and In Vivo Pharmacology

Ervin Pejo, B.S., Peter Santer, M.D., Spencer Jeffrey, Hilary Gallin, B.S., S. Shaukat Husain, D.Phil., Douglas E. Raines, M.D.

Anesthesiology. August 2014: 121(2):290–301

https://doi.org/10.1097/ALN.0000000000000268

Published: August 2014

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Articles

A Response Surface Model Approach for Continuous Measures of Hypnotic and Analgesic Effect during Sevoflurane–Remifentanil Interaction: Quantifying the Pharmacodynamic Shift Evoked by Stimulation

Bjorn Heyse, M.D., Johannes H. Proost, Pharm.D., Ph.D., Laura N. Hannivoort, M.D., Douglas J. Eleveld, Ph.D., Martin Luginbühl, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D., Hugo E. M. Vereecke, M.D., Ph.D.

Anesthesiology. June 2014: 120(6):1390–1399

https://doi.org/10.1097/ALN.0000000000000180

Published: June 2014

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Articles

Forebrain HCN1 Channels Contribute to Hypnotic Actions of Ketamine

Cheng Zhou, M.S., Jennifer E. Douglas, B.A., Natasha N. Kumar, Ph.D., Shaofang Shu, B.S., Douglas A. Bayliss, Ph.D., Xiangdong Chen, M.D., Ph.D.

Anesthesiology. April 2013: 118(4):785–795

https://doi.org/10.1097/ALN.0b013e318287b7c8

Published: April 2013

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Articles

Modifying Methoxycarbonyl Etomidate Inter-Ester Spacer Optimizes In Vitro Metabolic Stability and In Vivo Hypnotic Potency and Duration of Action

S. Shaukat Husain, Ph.D., Ervin Pejo, B.S., Rile Ge, M.D., Ph.D., Douglas E. Raines, M.D.

Anesthesiology. November 2012: 117(5):1027–1036

https://doi.org/10.1097/ALN.0b013e31826d3bef

Published: November 2012

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Articles

Electroencephalographic and Hypnotic Recoveries after Brief and Prolonged Infusions of Etomidate and Optimized Soft Etomidate Analogs

Rile Ge, M.D., Ph.D., Ervin Pejo, B.S., S. Shaukat Husain, Ph.D., Joseph F. Cotten, M.D., Ph.D., Douglas E. Raines, M.D.

Anesthesiology. November 2012: 117(5):1037–1043

https://doi.org/10.1097/ALN.0b013e31826d3de2

Published: November 2012

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Articles

Hypnotic Hypersensitivity to Volatile Anesthetics and Dexmedetomidine in Dopamine β-Hydroxylase Knockout Mice

Frances Y. Hu, B.A., George M. Hanna, M.D., Wei Han, B.S., Feras Mardini, B.S., Steven A. Thomas, M.D., Ph.D., Abraham J. Wyner, Ph.D., Max B. Kelz, M.D. Ph.D.

Anesthesiology. November 2012: 117(5):1006–1017

https://doi.org/10.1097/ALN.0b013e3182700ab9

Published: November 2012

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Articles

All Models Are Wrong

Steven L. Shafer, M.D.

Anesthesiology. February 2012: 116(2):240–241

https://doi.org/10.1097/ALN.0b013e318242a4a7

Published: February 2012

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Articles

Sevoflurane Remifentanil Interaction: Comparison of Different Response Surface Models

Bjorn Heyse, M.D., Johannes H. Proost, Pharm.D., Ph.D., Peter M. Schumacher, M.Sc., Ph.D., Thomas W. Bouillon, P.D. Dr. med., Hugo E. M. Vereecke, M.D., Ph.D., Douglas J. Eleveld, Ph.D., Martin Luginbühl, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D.

Anesthesiology. February 2012: 116(2):311–323

https://doi.org/10.1097/ALN.0b013e318242a2ec

Published: February 2012

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Articles

First Human Administration of MR04A3: A Novel Water-soluble Nonbenzodiazepine Sedative

J. Robert Sneyd, M.D., F.R.C.A., Ann E. Rigby-Jones, B.Sc., Ph.D., Maurice Cross, M.B., B.Chir., Hideharu Tominaga, B.Sc., Satoshi Shimizu, B.Sc., Takako Ohkura, Ph.D., Karen Grimsehl, F.R.C.A.

Anesthesiology. February 2012: 116(2):385–395

https://doi.org/10.1097/ALN.0b013e318242b2af

Published: February 2012

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Articles

Spectral Entropy as a Measure of Hypnosis and Hypnotic Drug Effect of Total Intravenous Anesthesia in Children during Slow Induction and Maintenance

Jaakko G. M. Klockars, M.D., Arja Hiller, M.D., Ph.D., Sinikka Münte, M.D., Ph.D., Mark J. van Gils, Ph.D., Tomi Taivainen, M.D., Ph.D.

Anesthesiology. February 2012: 116(2):340–351

https://doi.org/10.1097/ALN.0b013e3182410b5e

Published: February 2012

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Articles

Disentangling Hypnos from His Poppies

Jamie Sleigh, M.D.

Anesthesiology. August 2010: 113(2):271–272

https://doi.org/10.1097/ALN.0b013e3181e3db4d

Published: August 2010

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Articles

Noxious Stimulation Response Index: A Novel Anesthetic State Index Based on Hypnotic–Opioid Interaction

Martin Luginbühl, PD Dr. med., Peter M. Schumacher, M.Sc., Ph.D., Pascal Vuilleumier, M.D., Hugo Vereecke, M.D., Ph.D., Björn Heyse, M.D., Thomas W. Bouillon, PD Dr. med., Michel M. R. F. Struys, M.D., Ph.D.

Anesthesiology. April 2010: 112(4):872–880

https://doi.org/10.1097/ALN.0b013e3181d40368

Published: April 2010

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Articles

Comparison of Conventional Averaged and Rapid Averaged, Autoregressive-based Extracted Auditory Evoked Potentials for Monitoring the Hypnotic Level during Propofol Induction

Héctor Litvan, M.D., Erik W. Jensen, M.Sc., Ph.D., Josefina Galan, M.D., Jeppe Lund, Ph.D., Bernardo E. Rodriguez, M.Sc., Steen W. Henneberg, Ph.D., Pere Caminal, Ph.D., Juan M. Villar Landeira, M.D.

Anesthesiology. August 2002: 97(2):351–358

https://doi.org/10.1097/00000542-200208000-00011

Published: August 2002

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Articles

Sedative but Not Analgesic α 2 Agonist Tolerance Is Blocked by NMDA Receptor and Nitric Oxide Synthase Inhibitors

M. Frances Davies, Ph.D., Kristina Reid, B.S., Tian-Zhi Guo, M.D., Geeta S. Agashe, M.D., Yogen K. Amin, M.B. Ch.B., F.R.C.A., Mervyn Maze, M.B. Ch.B., F.R.C.A., F.R.C.P.

Anesthesiology. July 2001: 95(1):184–191

https://doi.org/10.1097/00000542-200107000-00029

Published: July 2001

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NARROW

Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on γ-Aminobutyric Acid Type A Receptors

Anesthesia Mechanisms: A Patchwork Quilt rather than a Wet Blanket?

High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics

Gone Fishing…

Does Equi–Minimum Alveolar Concentration Value Ensure Equivalent Analgesic or Hypnotic Potency?: A Comparison between Desflurane and Sevoflurane

Cyclopropyl-methoxycarbonyl Metomidate: Studies in a Lipopolysaccharide Inflammatory Model of Sepsis

Analogues of Etomidate: Modifications around Etomidate’s Chiral Carbon and the Impact on In Vitro and In Vivo Pharmacology

A Response Surface Model Approach for Continuous Measures of Hypnotic and Analgesic Effect during Sevoflurane–Remifentanil Interaction: Quantifying the Pharmacodynamic Shift Evoked by Stimulation

Forebrain HCN1 Channels Contribute to Hypnotic Actions of Ketamine

Modifying Methoxycarbonyl Etomidate Inter-Ester Spacer Optimizes In Vitro Metabolic Stability and In Vivo Hypnotic Potency and Duration of Action

Electroencephalographic and Hypnotic Recoveries after Brief and Prolonged Infusions of Etomidate and Optimized Soft Etomidate Analogs

Hypnotic Hypersensitivity to Volatile Anesthetics and Dexmedetomidine in Dopamine β-Hydroxylase Knockout Mice

All Models Are Wrong

Sevoflurane Remifentanil Interaction: Comparison of Different Response Surface Models

First Human Administration of MR04A3: A Novel Water-soluble Nonbenzodiazepine Sedative

Spectral Entropy as a Measure of Hypnosis and Hypnotic Drug Effect of Total Intravenous Anesthesia in Children during Slow Induction and Maintenance

Disentangling Hypnos from His Poppies

Noxious Stimulation Response Index: A Novel Anesthetic State Index Based on Hypnotic–Opioid Interaction

Comparison of Conventional Averaged and Rapid Averaged, Autoregressive-based Extracted Auditory Evoked Potentials for Monitoring the Hypnotic Level during Propofol Induction

Sedative but Not Analgesic α 2 Agonist Tolerance Is Blocked by NMDA Receptor and Nitric Oxide Synthase Inhibitors

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