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Articles

You Don’t Always Get What You Want!

Philip G. Morgan, M.D., Margaret M. Sedensky, M.D.

Anesthesiology. October 2024: 141(4):745–749

https://doi.org/10.1097/ALN.0000000000005143

Published: October 2024

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Articles

Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity

Zachariah P. G. Olufs, B.S., Barry Ganetzky, Ph.D., David A. Wassarman, Ph.D., Misha Perouansky, M.D.

Anesthesiology. October 2020: 133(4):839–851

https://doi.org/10.1097/ALN.0000000000003486

Published: October 2020

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Articles

An Assessment of Penetrance and Clinical Expression of Malignant Hyperthermia in Individuals Carrying Diagnostic Ryanodine Receptor 1 Gene Mutations

Carlos A. Ibarra Moreno, M.D., Ph.D., Sally Hu, M.D., Natalia Kraeva, Ph.D., Frank Schuster, M.D., Stephan Johannsen, M.D., Henrik Rueffert, M.D., Werner Klingler, M.D., Ph.D., Luc Heytens, M.D., Ph.D., Sheila Riazi, M.Sc., M.D.

Anesthesiology. November 2019: 131(5):983–991

https://doi.org/10.1097/ALN.0000000000002813

Published: November 2019

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Articles

Syntaxin1A Neomorphic Mutations Promote Rapid Recovery from Isoflurane Anesthesia in Drosophila melanogaster

Michael Troup, Ph.D., Oressia H. Zalucki, Ph.D., Benjamin D. Kottler, Ph.D., Shanker Karunanithi, Ph.D., Victor Anggono, Ph.D., Bruno van Swinderen, Ph.D.

Anesthesiology. September 2019: 131(3):555–568

https://doi.org/10.1097/ALN.0000000000002850

Published: September 2019

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Articles

Alphaxalone Binds in Inner Transmembrane β + –α − Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors

Alexis M. Ziemba, B.A., Andrea Szabo, B.S., David W. Pierce, B.S., Marian Haburcak, Ph.D., Alex T. Stern, B.S., Anahita Nourmahnad, B.S., Elizabeth S. Halpin, B.A., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. February 2018: 128(2):338–351

https://doi.org/10.1097/ALN.0000000000001978

Published: February 2018

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Articles

p.L1612P, a Novel Voltage-gated Sodium Channel Nav1.7 Mutation Inducing a Cold Sensitive Paroxysmal Extreme Pain Disorder

Marc R. Suter, M.D., Zahurul A. Bhuiyan, M.D., Cédric J. Laedermann, Ph.D., Thierry Kuntzer, M.D., Muriel Schaller, M.D., Maurice W. Stauffacher, M.D., Eliane Roulet, M.D., Hugues Abriel, M.D., Ph.D., Isabelle Decosterd, M.D., Christian Wider, M.D.

Anesthesiology. February 2015: 122(2):414–423

https://doi.org/10.1097/ALN.0000000000000476

Published: February 2015

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Articles

Characterization of a Computationally Designed Water-soluble Human μ-Opioid Receptor Variant Using Available Structural Information

Xuelian Zhao, M.D., Ph.D., Jose Manuel Perez-Aguilar, Ph.D., Felipe Matsunaga, B.A., Mitchell Lerner, Ph.D., Jin Xi, M.S., Bernard Selling, Ph.D., A. T. Charlie Johnson, Jr., Ph.D., Jeffery G. Saven, Ph.D., Renyu Liu, M.D., Ph.D.

Anesthesiology. October 2014: 121(4):866–875

https://doi.org/10.1097/ALN.0000000000000308

Published: October 2014

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Articles

Exome Sequencing Reveals Novel Rare Variants in the Ryanodine Receptor and Calcium Channel Genes in Malignant Hyperthermia Families

Jerry H. Kim, M.D., Gail P. Jarvik, M.D., Ph.D., Brian L. Browning, Ph.D., Ramakrishnan Rajagopalan, M.S., Adam S. Gordon, B.A., Mark J. Rieder, Ph.D., Peggy D. Robertson, Ph.D., Deborah A. Nickerson, Ph.D., Nickla A. Fisher, M.Sc., Philip M. Hopkins, M.B.B.S., M.D., F.R.C.A.

Anesthesiology. November 2013: 119(5):1054–1065

https://doi.org/10.1097/ALN.0b013e3182a8a998

Published: November 2013

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Articles

Using Exome Data to Identify Malignant Hyperthermia Susceptibility Mutations

Stephen G. Gonsalves, M.S.N., David Ng, M.D., Jennifer J. Johnston, Ph.D., Jamie K. Teer, Ph.D., Peter D. Stenson, Ph.D., David N. Cooper, Ph.D., James C. Mullikin, Ph.D., Leslie G. Biesecker, M.D.

Anesthesiology. November 2013: 119(5):1043–1053

https://doi.org/10.1097/ALN.0b013e3182a8a8e7

Published: November 2013

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Articles

Skeletal Muscle Ryanodine Receptor Mutations Associated with Malignant Hyperthermia Showed Enhanced Intensity and Sensitivity to Triggering Drugs when Expressed in Human Embryonic Kidney Cells

Keisaku Sato, Ph.D., Cornelia Roesl, M.Sc., Neil Pollock, M.B.Ch.B., F.R.C.A., F.A.N.Z.C.A., M.D., Kathryn M. Stowell, Ph.D.

Anesthesiology. July 2013: 119(1):111–118

https://doi.org/10.1097/ALN.0b013e31828cebfe

Published: July 2013

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Articles

The Benzodiazepine Diazepam Potentiates Responses of α1β2γ2L γ-Aminobutyric Acid Type A Receptors Activated by either γ-Aminobutyric Acid or Allosteric Agonists

Ping Li, M.D., Ph.D., Megan M. Eaton, M.Sc., Joe Henry Steinbach, Ph.D., Gustav Akk, Ph.D.

Anesthesiology. June 2013: 118(6):1417–1425

https://doi.org/10.1097/ALN.0b013e318289bcd3

Published: June 2013

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Articles

Mutations M287L and Q266I in the Glycine Receptor α1 Subunit Change Sensitivity to Volatile Anesthetics in Oocytes and Neurons, but Not the Minimal Alveolar Concentration in Knockin Mice

Cecilia M. Borghese, Ph.D., Wei Xiong, Ph.D., S. Irene Oh, B.S., Angel Ho, B.S., S. John Mihic, Ph.D., Li Zhang, M.D., David M. Lovinger, Ph.D., Gregg E. Homanics, Ph.D., Edmond I. Eger, M.D., R. Adron Harris, Ph.D.

Anesthesiology. October 2012: 117(4):765–771

https://doi.org/10.1097/ALN.0b013e31826a0d93

Published: October 2012

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Articles

Identification of Two Mutations (F758W and F758Y) in the N -methyl-D-aspartate Receptor Glycine-binding Site that Selectively Prevent Competitive Inhibition by Xenon without Affecting Glycine Binding

Scott P. Armstrong, M.Sc., Paul J. Banks, Ph.D., Thomas J. W. McKitrick, B.Sc., Catharine H. Geldart, B.Sc., Christopher J. Edge, Ph.D., F.R.C.A., Rohan Babla, B.Sc., Constantinos Simillis, B.Sc., M.B.B.S., Nicholas P. Franks, Ph.D., F.R.S., F.R.C.A., F.Med.Sci., Robert Dickinson, Ph.D.

Anesthesiology. July 2012: 117(1):38–47

https://doi.org/10.1097/ALN.0b013e31825ada2e

Published: July 2012

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Articles

Regulation of Peripheral Clock to Oscillation of Substance P Contributes to Circadian Inflammatory Pain

Jing Zhang, Ph.D., Huili Li, M.S., Huajing Teng, Ph.D., Ting Zhang, Ph.D., Yonglun Luo, Ph.D., Mei Zhao, Ph.D., Yun-Qing Li, Ph.D., Zhong Sheng Sun, Ph.D.

Anesthesiology. July 2012: 117(1):149–160

https://doi.org/10.1097/ALN.0b013e31825b4fc1

Published: July 2012

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Articles

A Gain-of-function Mutation in Adenylate Cyclase Confers Isoflurane Resistance in Caenorhabditis elegans

Owais Saifee, M.D., Ph.D., Laura B. Metz, B.Sc., Michael L. Nonet, Ph.D., C. Michael Crowder, M.D., Ph.D.

Anesthesiology. December 2011: 115(6):1162–1171

https://doi.org/10.1097/ALN.0b013e318239355d

Published: December 2011

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Articles

Identical de novo Mutation in the Type 1 Ryanodine Receptor Gene Associated with Fatal, Stress-induced Malignant Hyperthermia in Two Unrelated Families

Linda Groom, B.Sc., Sheila M. Muldoon, M.D., Zhen Zhi Tang, Ph.D., Barbara W. Brandom, M.D., Munkhuu Bayarsaikhan, Ph.D., Saiid Bina, Ph.D., Hee-Suk Lee, M.D., Xing Qiu, Ph.D., Nyamkhishig Sambuughin, Ph.D., Robert T. Dirksen, Ph.D.

Anesthesiology. November 2011: 115(5):938–945

https://doi.org/10.1097/ALN.0b013e3182320068

Published: November 2011

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Articles

Anesthesia Literature Review

Timothy J. Brennan, Ph.D., M.D.

Anesthesiology. October 2010: 113(4):962–967

https://doi.org/10.1097/ALN.0b013e3181f20ca2

Published: October 2010

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Articles

Functional Studies of RYR1 Mutations in the Skeletal Muscle Ryanodine Receptor Using Human RYR1 Complementary DNA

Keisaku Sato, M.Sc., Neil Pollock, M.B.Ch.B., Kathryn M. Stowell, Ph.D.

Anesthesiology. June 2010: 112(6):1350–1354

https://doi.org/10.1097/ALN.0b013e3181d69283

Published: June 2010

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Articles

γ-Amino Butyric Acid Type A Receptor Mutations at β2N265 Alter Etomidate Efficacy While Preserving Basal and Agonist-dependent Activity

Rooma Desai, Ph.D., Dirk Ruesch, M.D., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. October 2009: 111(4):774–784

https://doi.org/10.1097/ALN.0b013e3181b55fae

Published: October 2009

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Articles

Anesthetic Sensitivity: Learning to Fly

Max B. Kelz, M.D., Ph.D., Eliot Friedman, M.D.

Anesthesiology. July 2009: 111(1):5–7

https://doi.org/10.1097/ALN.0b013e3181a3278b

Published: July 2009

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NARROW

You Don’t Always Get What You Want!

Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity

An Assessment of Penetrance and Clinical Expression of Malignant Hyperthermia in Individuals Carrying Diagnostic Ryanodine Receptor 1 Gene Mutations

Syntaxin1A Neomorphic Mutations Promote Rapid Recovery from Isoflurane Anesthesia in Drosophila melanogaster

Alphaxalone Binds in Inner Transmembrane β + –α − Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors

p.L1612P, a Novel Voltage-gated Sodium Channel Nav1.7 Mutation Inducing a Cold Sensitive Paroxysmal Extreme Pain Disorder

Characterization of a Computationally Designed Water-soluble Human μ-Opioid Receptor Variant Using Available Structural Information

Exome Sequencing Reveals Novel Rare Variants in the Ryanodine Receptor and Calcium Channel Genes in Malignant Hyperthermia Families

Using Exome Data to Identify Malignant Hyperthermia Susceptibility Mutations

Skeletal Muscle Ryanodine Receptor Mutations Associated with Malignant Hyperthermia Showed Enhanced Intensity and Sensitivity to Triggering Drugs when Expressed in Human Embryonic Kidney Cells

The Benzodiazepine Diazepam Potentiates Responses of α1β2γ2L γ-Aminobutyric Acid Type A Receptors Activated by either γ-Aminobutyric Acid or Allosteric Agonists

Mutations M287L and Q266I in the Glycine Receptor α1 Subunit Change Sensitivity to Volatile Anesthetics in Oocytes and Neurons, but Not the Minimal Alveolar Concentration in Knockin Mice

Identification of Two Mutations (F758W and F758Y) in the N -methyl-D-aspartate Receptor Glycine-binding Site that Selectively Prevent Competitive Inhibition by Xenon without Affecting Glycine Binding

Regulation of Peripheral Clock to Oscillation of Substance P Contributes to Circadian Inflammatory Pain

A Gain-of-function Mutation in Adenylate Cyclase Confers Isoflurane Resistance in Caenorhabditis elegans

Identical de novo Mutation in the Type 1 Ryanodine Receptor Gene Associated with Fatal, Stress-induced Malignant Hyperthermia in Two Unrelated Families

Anesthesia Literature Review

Functional Studies of RYR1 Mutations in the Skeletal Muscle Ryanodine Receptor Using Human RYR1 Complementary DNA

γ-Amino Butyric Acid Type A Receptor Mutations at β2N265 Alter Etomidate Efficacy While Preserving Basal and Agonist-dependent Activity

Anesthetic Sensitivity: Learning to Fly

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