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Articles

Developmental Anesthesia Neurotoxicity Research in Humans: Moving the Concept

Laszlo Vutskits, M.D., Ph.D., Andrew J. Davidson, M.B.B.S., M.D.

Anesthesiology. September 2024: 141(3):431–433

https://doi.org/10.1097/ALN.0000000000005126

Published: September 2024

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Articles

Stress Pathways Induced by Volatile Anesthetics and Failure of Preconditioning in a Mitochondrial Complex I Mutant

Zachariah P. G. Olufs, B.S., David A. Wassarman, Ph.D., Misha Perouansky, M.D.

Anesthesiology. March 2024: 140(3):463–482

https://doi.org/10.1097/ALN.0000000000004874

Published: March 2024

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Articles

Developmental Anesthesia Neurotoxicity: Lessons from the Heart

Caleb Ing, M.D., M.S., Laszlo Vutskits, M.D., Ph.D.

Anesthesiology. October 2023: 139(4):371–373

https://doi.org/10.1097/ALN.0000000000004648

Published: October 2023

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Articles

Anesthesia and Developing Brains: Unanswered Questions and Proposed Paths Forward

Caleb Ing, M.D., M.S., David O. Warner, M.D., Lena S. Sun, M.D., Randall P. Flick, M.D., M.P.H., Andrew J. Davidson, M.B.B.S., M.D., F.A.N.Z.C.A., F.A.H.M.S., Laszlo Vutskits, M.D., Ph.D., Mary Ellen McCann, M.D., James O’Leary, M.D., David C. Bellinger, Ph.D., M.Sc., Virginia Rauh, Sc.D., Beverley A. Orser, M.D., Ph.D., F.R.C.P.C., Santhanam Suresh, M.D., Dean B. Andropoulos, M.D., M.H.C.M.

Anesthesiology. March 2022: 136(3):500–512

https://doi.org/10.1097/ALN.0000000000004116

Published: March 2022

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Articles

Androgenic Modulation of the Chloride Transporter NKCC1 Contributes to Age-dependent Isoflurane Neurotoxicity in Male Rats

Gregory A. Chinn, M.D., Ph.D., Jennifer M. Sasaki Russell, Ph.D., Nicole A. Yabut, B.S., Deenu Maharjan, M.D., Jeffrey W. Sall, Ph.D., M.D.

Anesthesiology. October 2020: 133(4):852–866

https://doi.org/10.1097/ALN.0000000000003437

Published: October 2020

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Articles

GAS, PANDA, and MASK: No Evidence of Clinical Anesthetic Neurotoxicity!

Laszlo Vutskits, M.D., Ph.D., Deborah J. Culley, M.D.

Anesthesiology. October 2019: 131(4):762–764

https://doi.org/10.1097/ALN.0000000000002863

Published: October 2019

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Articles

The Basics of Anesthesia, 7th Edition.

Adolfo Gonzalez, M.D., Stephen Kimatian, M.D., F.A.A.P.

Anesthesiology. December 2018: 129(6):1194–1195

https://doi.org/10.1097/ALN.0000000000002432

Published: December 2018

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Articles

Noninvasive Tracking of Anesthesia Neurotoxicity in the Developing Rodent Brain

Rany Makaryus, M.D., Hedok Lee, Ph.D., John Robinson, Ph.D., Grigori Enikolopov, Ph.D., Helene Benveniste, M.D., Ph.D.

Anesthesiology. July 2018: 129(1):118–130

https://doi.org/10.1097/ALN.0000000000002229

Published: July 2018

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Articles

Are We Moving Closer to Noninvasive Imaging and Monitoring of Neonatal Anesthesia–induced Neurotoxicity?

Helene Benveniste, M.D., Ph.D., Rany Makaryus, M.D.

Anesthesiology. July 2016: 125(1):22–24

https://doi.org/10.1097/ALN.0000000000001155

Published: July 2016

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Articles

Astrocytes Protect against Isoflurane Neurotoxicity by Buffering pro-brain–derived Neurotrophic Factor

Creed M. Stary, M.D., Ph.D., Xiaoyun Sun, M.D., Rona G. Giffard, Ph.D., M.D.

Anesthesiology. October 2015: 123(4):810–819

https://doi.org/10.1097/ALN.0000000000000824

Published: October 2015

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Articles

Down-regulation of MicroRNA-21 Is Involved in the Propofol-induced Neurotoxicity Observed in Human Stem Cell–derived Neurons

Danielle M. Twaroski, B.S., Yasheng Yan, B.S., Jessica M. Olson, M.S., Zeljko J. Bosnjak, Ph.D., Xiaowen Bai, M.D., Ph.D.

Anesthesiology. October 2014: 121(4):786–800

https://doi.org/10.1097/ALN.0000000000000345

Published: October 2014

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Articles

Anesthetic-related Neurotoxicity in the Young and Outcome Measures: The Devil Is in the Details

Randall P. Flick, M.D., Michael E. Nemergut, M.D., Ph.D., Kaare Christensen, M.D., Ph.D., D.M.Sc., Tom G. Hansen, M.D., Ph.D.

Anesthesiology. June 2014: 120(6):1303–1305

https://doi.org/10.1097/ALN.0000000000000249

Published: June 2014

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Articles

Nociceptor-selective Peripheral Nerve Block Induces Delayed Mechanical Hypersensitivity and Neurotoxicity in Rats

Christopher M. Peters, Ph.D., Douglas Ririe, M.D., Ph.D., Timothy T. Houle, Ph.D., Carol A. Aschenbrenner, M.A., James C. Eisenach, M.D.

Anesthesiology. April 2014: 120(4):976–986

https://doi.org/10.1097/ALN.0000000000000088

Published: April 2014

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Articles

Xenon Neurotoxicity in Rat Hippocampal Slice Cultures Is Similar to Isoflurane and Sevoflurane

Heather Brosnan, B.S., Philip E. Bickler, M.D., Ph.D.

Anesthesiology. August 2013: 119(2):335–344

https://doi.org/10.1097/ALN.0b013e31829417f0

Published: August 2013

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Articles

Sevoflurane Anesthesia in Pregnant Mice Induces Neurotoxicity in Fetal and Offspring Mice

Hui Zheng, M.D., Ph.D., Yuanlin Dong, M.D., M.S., Zhipeng Xu, M.D., Ph.D., Gregory Crosby, M.D., Deborah J. Culley, M.D., Yiying Zhang, M.D., M.S., Zhongcong Xie, M.D., Ph.D.

Anesthesiology. March 2013: 118(3):516–526

https://doi.org/10.1097/ALN.0b013e3182834d5d

Published: March 2013

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Articles

A Users' Guide to Interpreting Observational Studies of Pediatric Anesthetic Neurotoxicity: The Lessons of Sir Bradford Hill

Randall P. Flick, M.D., David O. Warner, M.D.

Anesthesiology. September 2012: 117(3):459–462

https://doi.org/10.1097/ALN.0b013e31826446a5

Published: September 2012

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Articles

Neurotoxicity and the Need for Anesthesia in the Newborn: Does the Emperor Have No Clothes?

Andrew J. Davidson, M.B.B.S., M.D., F.A.N.Z.C.A.

Anesthesiology. March 2012: 116(3):507–509

https://doi.org/10.1097/ALN.0b013e3182475673

Published: March 2012

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Articles

Propofol Neurotoxicity Is Mediated by p75 Neurotrophin Receptor Activation

Matthew L. Pearn, M.D., Yue Hu, B.S., Ingrid R. Niesman, M.S., Hemal H. Patel, Ph.D., John C. Drummond, M.D., David M. Roth, Ph.D., M.D., Katerina Akassoglou, Ph.D., Piyush M. Patel, M.D., Brian P. Head, M.S., Ph.D.

Anesthesiology. February 2012: 116(2):352–361

https://doi.org/10.1097/ALN.0b013e318242a48c

Published: February 2012

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Articles

A New Phase in Anesthetic-induced Neurotoxicity Research

Phil G. Morgan, M.D., Margaret Sedensky, M.D.

Anesthesiology. January 2011: 114(1):10–11

https://doi.org/10.1097/ALN.0b013e318201dda0

Published: January 2011

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Articles

Isoflurane Neurotoxicity Is Mediated by p75 NTR -RhoA Activation and Actin Depolymerization

Brian P. Lemkuil, M.D., Brian P. Head, M.S., Ph.D., Matthew L. Pearn, M.D., Hemal H. Patel, Ph.D., John C. Drummond, M.D., Piyush M. Patel, M.D.

Anesthesiology. January 2011: 114(1):49–57

https://doi.org/10.1097/ALN.0b013e318201dcb3

Published: January 2011

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NARROW

Developmental Anesthesia Neurotoxicity Research in Humans: Moving the Concept

Stress Pathways Induced by Volatile Anesthetics and Failure of Preconditioning in a Mitochondrial Complex I Mutant

Developmental Anesthesia Neurotoxicity: Lessons from the Heart

Anesthesia and Developing Brains: Unanswered Questions and Proposed Paths Forward

Androgenic Modulation of the Chloride Transporter NKCC1 Contributes to Age-dependent Isoflurane Neurotoxicity in Male Rats

GAS, PANDA, and MASK: No Evidence of Clinical Anesthetic Neurotoxicity!

The Basics of Anesthesia, 7th Edition.

Noninvasive Tracking of Anesthesia Neurotoxicity in the Developing Rodent Brain

Are We Moving Closer to Noninvasive Imaging and Monitoring of Neonatal Anesthesia–induced Neurotoxicity?

Astrocytes Protect against Isoflurane Neurotoxicity by Buffering pro-brain–derived Neurotrophic Factor

Down-regulation of MicroRNA-21 Is Involved in the Propofol-induced Neurotoxicity Observed in Human Stem Cell–derived Neurons

Anesthetic-related Neurotoxicity in the Young and Outcome Measures: The Devil Is in the Details

Nociceptor-selective Peripheral Nerve Block Induces Delayed Mechanical Hypersensitivity and Neurotoxicity in Rats

Xenon Neurotoxicity in Rat Hippocampal Slice Cultures Is Similar to Isoflurane and Sevoflurane

Sevoflurane Anesthesia in Pregnant Mice Induces Neurotoxicity in Fetal and Offspring Mice

A Users' Guide to Interpreting Observational Studies of Pediatric Anesthetic Neurotoxicity: The Lessons of Sir Bradford Hill

Neurotoxicity and the Need for Anesthesia in the Newborn: Does the Emperor Have No Clothes?

Propofol Neurotoxicity Is Mediated by p75 Neurotrophin Receptor Activation

A New Phase in Anesthetic-induced Neurotoxicity Research

Isoflurane Neurotoxicity Is Mediated by p75 NTR -RhoA Activation and Actin Depolymerization

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