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Articles

Local Anesthetic Cardiac Toxicity Is Mediated by Cardiomyocyte Calcium Dynamics

Julia Plakhotnik, B.Sc., Libo Zhang, M.D., Ph.D., Marvin Estrada, R.V.T., John G. Coles, M.D., Per-Arne Lonnqvist, M.D., Ph.D., Jason T. Maynes, M.D., Ph.D.

Anesthesiology. December 2022: 137(6):687–703

DOI: https://doi.org/10.1097/ALN.0000000000004389

Published: December 2022

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Articles

Advances in Reversal Strategies of Opioid-induced Respiratory Toxicity

Rutger van der Schrier, M.D., Jack D. C. Dahan, B.Sc., Martijn Boon, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. April 2022: 136(4):618–632

DOI: https://doi.org/10.1097/ALN.0000000000004096

Published: April 2022

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Articles

Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity

Zachariah P. G. Olufs, B.S., Barry Ganetzky, Ph.D., David A. Wassarman, Ph.D., Misha Perouansky, M.D.

Anesthesiology. October 2020: 133(4):839–851

DOI: https://doi.org/10.1097/ALN.0000000000003486

Published: October 2020

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Articles

Novel Clinical Trial Designs to Improve the Efficiency of Research

Daniel I. Sessler, M.D., Paul S. Myles, M.B., B.S., M.P.H., D.Sc., F.A.N.Z.C.A.

Anesthesiology. January 2020: 132(1):69–81

DOI: https://doi.org/10.1097/ALN.0000000000002989

Published: January 2020

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Articles

Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion

Michael R. Fettiplace, M.S., Katarzyna Kowal, B.S., Richard Ripper, C.V.T., Alexandria Young, B.S., Kinga Lis, B.S., Israel Rubinstein, M.D., Marcelo Bonini, Ph.D., Richard Minshall, Ph.D., Guy Weinberg, M.D.

Anesthesiology. February 2016: 124(2):428–442

DOI: https://doi.org/10.1097/ALN.0000000000000974

Published: February 2016

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Articles

Neosaxitoxin in Rat Sciatic Block: Improved Therapeutic Index Using Combinations with Bupivacaine, with and without Epinephrine

Jay S. Templin, M.S., Matthew C. Wylie, M.S., M.D., Joseph D. Kim, M.A., Katherine E. Kurgansky, M.P.H., Grzegorz Gorski, M.S., John Kheir, M.D., David Zurakowski, Ph.D., Gabriel Corfas, Ph.D., Charles Berde, M.D., Ph.D.

Anesthesiology. October 2015: 123(4):886–898

DOI: https://doi.org/10.1097/ALN.0000000000000832

Published: October 2015

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Articles

Discovery of a Novel General Anesthetic Chemotype Using High-throughput Screening

Andrew R. McKinstry-Wu, M.D., Weiming Bu, Ph.D., Ganesha Rai, Ph.D., Wendy A. Lea, Ph.D., Brian P. Weiser, B.S., David F. Liang, B.S., Anton Simeonov, Ph.D., Ajit Jadhav, Ph.D., David J. Maloney, Ph.D., Roderic G. Eckenhoff, M.D.

Anesthesiology. February 2015: 122(2):325–333

DOI: https://doi.org/10.1097/ALN.0000000000000505

Published: February 2015

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Articles

Preclinical Toxicity Screening of Intrathecal Oxytocin in Rats and Dogs

Tony L. Yaksh, Ph.D., Shotaro Hobo, M.D., Christopher Peters, Ph.D., Kent G. Osborn, D.V.M., Ph.D., Philip J. Richter, Jr, D.V.M., Ph.D., D.A.C.L.A.M., Steven S. Rossi, Ph.D., Marjorie R. Grafe, M.D., Ph.D., James C. Eisenach, M.D.

Anesthesiology. April 2014: 120(4):951–961

DOI: https://doi.org/10.1097/ALN.0000000000000148

Published: April 2014

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Articles

Despite Differences in Cytosolic Calcium Regulation, Lidocaine Toxicity Is Similar in Adult and Neonatal Rat Dorsal Root Ganglia In Vitro

Lisa V. Doan, M.D., Olga Eydlin, M.D., Boris Piskoun, B.A., Richard P. Kline, Ph.D., Esperanza Recio-Pinto, Ph.D., Andrew D. Rosenberg, M.D., Thomas J. J. Blanck, M.D., Ph.D., Fang Xu, Ph.D.

Anesthesiology. January 2014: 120(1):50–61

DOI: https://doi.org/10.1097/ALN.0b013e3182a2a561

Published: January 2014

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Articles

Assessing the Utility of the Utility Function

Evan D. Kharasch, M.D., Ph.D., Carl E. Rosow, M.D., Ph.D.

Anesthesiology. September 2013: 119(3):504–506

DOI: https://doi.org/10.1097/ALN.0b013e31829ce70b

Published: September 2013

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Articles

Evaluation of Spinal Toxicity and Long-term Spinal Reflex Function after Intrathecal Levobupivaciane in the Neonatal Rat

Emre Hamurtekin, M.D., Ph.D., Bethany L. Fitzsimmons, M.Sc., Veronica I. Shubayev, M.D., Marjorie R. Grafe, M.D., Ph.D., Ronald Deumens, Ph.D., Tony L. Yaksh, Ph.D., Suellen M. Walker, M.B., B.S., Ph.D., F.A.N.Z.C.A.

Anesthesiology. July 2013: 119(1):142–155

DOI: https://doi.org/10.1097/ALN.0b013e31828fc7e7

Published: July 2013

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Articles

Case Reports Are Leaving ANESTHESIOLOGY, but Not the Specialty

James C. Eisenach, M.D.

Anesthesiology. March 2013: 118(3):479–480

DOI: https://doi.org/10.1097/ALN.0b013e318280a44f

Published: March 2013

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Articles

Lipid Resuscitation of Bupivacaine Toxicity: Long-chain Triglyceride Emulsion Provides Benefits over Long- and Medium-chain Triglyceride Emulsion

Zhengqian Li, B.S., Yun Xia, M.D., Ph.D., Xiaoxi Dong, M.D., Hongfei Chen, B.S., Fangfang Xia, B.S., Xianqin Wang, Ph.D., Huimin Dong, M.D., Zhousheng Jin, B.S., Xili Ding, B.S., Thomas J. Papadimos, M.D., M.P.H., Xuzhong Xu, M.D.

Anesthesiology. December 2011: 115(6):1219–1228

DOI: https://doi.org/10.1097/ALN.0b013e318238be73

Published: December 2011

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Articles

TASK Channel Deletion Reduces Sensitivity to Local Anesthetic-induced Seizures

Guizhi Du, M.D., Xiangdong Chen, M.D., Ph.D., Marko S. Todorovic, B.S., Shaofang Shu, B.S., Jaideep Kapur, M.D., Douglas A. Bayliss, Ph.D.

Anesthesiology. November 2011: 115(5):1003–1011

DOI: https://doi.org/10.1097/ALN.0b013e3182343660

Published: November 2011

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Articles

Disruption of the Transient Receptor Potential Vanilloid 1 Can Affect Survival, Bacterial Clearance, and Cytokine Gene Expression during Murine Sepsis

Virginia Guptill, Ph.D., Xizhong Cui, M.D., Ph.D., Alfia Khaibullina, Ph.D., Jason M. Keller, B.S., Nicholas Spornick, B.S., Andrew Mannes, M.D., Michael Iadarola, Ph.D., Zenaide M. N. Quezado, M.D.

Anesthesiology. May 2011: 114(5):1190–1199

DOI: https://doi.org/10.1097/ALN.0b013e318212515b

Published: May 2011

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Articles

2009 in Review: Advancing Medicine in Anesthesiology

Alain Borgeat, M.D., Timothy J. Brennan, Ph.D., M.D., James C. Eisenach, M.D., Hugh C. Hemmings, M.D., Ph.D., Shiroh Isono, M.D., Judy R. Kersten, M.D., Eberhard Kochs, M.D., Ph.D., Bruno Riou, M.D., Ph.D., David S. Warner, M.D., Ph.D.

Anesthesiology. December 2009: 111(6):1192–1196

DOI: https://doi.org/10.1097/ALN.0b013e3181c1879b

Published: December 2009

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Articles

Neurotoxicity of General Anesthetics: Cause for Concern?

Misha Perouansky, M.D., Hugh C. Hemmings, M.D., Ph.D., Bruno Riou, M.D.

Anesthesiology. December 2009: 111(6):1365–1371

DOI: https://doi.org/10.1097/ALN.0b013e3181bf1d61

Published: December 2009

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Articles

Hemoglobin-based Oxygen Carriers: Current Status and Future Directions

Toby A. Silverman, M.D., Richard B. Weiskopf, M.D., for the Planning Committee and the Speakers

Anesthesiology. November 2009: 111(5):946–963

DOI: https://doi.org/10.1097/ALN.0b013e3181ba3c2c

Published: November 2009

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Articles

“Above All, Do No Harm”: Hippocrates

Peter Gerner, M.D.

Anesthesiology. November 2009: 111(5):938–939

DOI: https://doi.org/10.1097/ALN.0b013e3181bbcd2c

Published: November 2009

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Articles

Role for Metallothioneins-I/II in Isoflurane Preconditioning of Primary Murine Neuronal Cultures

Scott D. Edmands, M.A., Adam C. Hall, Ph.D.

Anesthesiology. March 2009: 110(3):538–547

DOI: https://doi.org/10.1097/ALN.0b013e3181974bba

Published: March 2009

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NARROW

Local Anesthetic Cardiac Toxicity Is Mediated by Cardiomyocyte Calcium Dynamics

Advances in Reversal Strategies of Opioid-induced Respiratory Toxicity

Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity

Novel Clinical Trial Designs to Improve the Efficiency of Research

Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion

Neosaxitoxin in Rat Sciatic Block: Improved Therapeutic Index Using Combinations with Bupivacaine, with and without Epinephrine

Discovery of a Novel General Anesthetic Chemotype Using High-throughput Screening

Preclinical Toxicity Screening of Intrathecal Oxytocin in Rats and Dogs

Despite Differences in Cytosolic Calcium Regulation, Lidocaine Toxicity Is Similar in Adult and Neonatal Rat Dorsal Root Ganglia In Vitro

Assessing the Utility of the Utility Function

Evaluation of Spinal Toxicity and Long-term Spinal Reflex Function after Intrathecal Levobupivaciane in the Neonatal Rat

Case Reports Are Leaving ANESTHESIOLOGY, but Not the Specialty

Lipid Resuscitation of Bupivacaine Toxicity: Long-chain Triglyceride Emulsion Provides Benefits over Long- and Medium-chain Triglyceride Emulsion

TASK Channel Deletion Reduces Sensitivity to Local Anesthetic-induced Seizures

Disruption of the Transient Receptor Potential Vanilloid 1 Can Affect Survival, Bacterial Clearance, and Cytokine Gene Expression during Murine Sepsis

2009 in Review: Advancing Medicine in Anesthesiology

Neurotoxicity of General Anesthetics: Cause for Concern?

Hemoglobin-based Oxygen Carriers: Current Status and Future Directions

“Above All, Do No Harm”: Hippocrates

Role for Metallothioneins-I/II in Isoflurane Preconditioning of Primary Murine Neuronal Cultures

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