1-20 of 484 Search Results for

Analgesics: alfentanil

Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
This article has a Visual Abstract This article has an Audio Podcast
Publication: Anesthesiology
Anesthesiology. June 2024: 140(6):1076–1087
Published: June 2024
... and analgesics that can lead to serious complications in perioperative patients. 1 Since receptor-specific antagonists are not available for most of the nonopioid anesthetics, agnostic respiratory stimulants that increase breathing activity regardless of the underlying cause of respiratory depression...
Articles
Publication: Anesthesiology
Anesthesiology. March 2024: 140(3):632–633
Published: March 2024
... present in humans, because opiorphin rapidly cycles into STR-324 under physiologic conditions. 2 Experimental studies demonstrated the strong analgesic properties of STR-324 in a rodent model of plantar-incision pain. 3 Potentiation of endogenous opioid peptides represents a novel approach to pain...
Articles
This article has a Visual Abstract This article has a Video Abstract This article has an Audio Podcast
Publication: Anesthesiology
Anesthesiology. July 2023: 139(1):16–34
Published: July 2023
... in perioperative, emergency department, and other acute care settings. Morphine and hydromorphone are postoperative analgesic standards. Nevertheless, their comparative effects and side effects, timing, and respective variabilities remain poorly understood. This study tested the hypothesis that IV morphine...
Articles
Articles
Publication: Anesthesiology
Anesthesiology. December 2022: 137(6):735–741
Published: December 2022
... but not widely recognized concept associated with respiratory depression is a pain–sedation mismatch, 33 in which a sedated postoperative patient reports severe pain and receives further opioid analgesic treatment despite excessive sedation. 33 Episodes of respiratory depression identified during...
Articles
This article has a Video Abstract
Publication: Anesthesiology
Anesthesiology. October 2022: 137(4):446–458
Published: October 2022
...) pretreatment followed by induction of alfentanil-induced respiratory depression (alfentanil target concentration, 100 ng/ml) was tested. Primary endpoint was ventilation at an extrapolated end-tidal carbon dioxide concentration of 55 mmHg (V̇ E 55). Next, the ability of four subsequent and increasing infusions...
Articles
Publication: Anesthesiology
Anesthesiology. June 2022: 136(6):888–900
Published: June 2022
... with analgesia. 10 For neostigmine, we injected a drug in a lumbar interspace, leaving the needle in place for 2 h for CSF sampling; Steve Shafer successfully modeled the spinal cord analgesic effects in the foot and in the hand from CSF levels at the injection site, using a concept he called observation from...
Articles
This article has a Visual Abstract
Publication: Anesthesiology
Anesthesiology. May 2022: 136(5):792–801
Published: May 2022
... of chronic pain, and patient compliance can be low due to fear of dissociation. It has been suggested that ketamine analgesia and antidepressant properties are highly associated and possibly even generated by its dissociative effects. 3–5 This would suggest that the dissociative and analgesic effects...
Articles
Publication: Anesthesiology
Anesthesiology. April 2022: 136(4):618–632
Published: April 2022
..., immunization against fentanyl reduced respiratory depression, and showed cross-reactivity with sufentanil, albeit only for its analgesic effects, but not with alfentanil or remifentanil. 76 In this same study, immunization did not interfere with propofol, dexmedetomidine, or isoflurane anesthesia...
Articles
Publication: Anesthesiology
Anesthesiology. August 2021: 135(2):350–365
Published: August 2021
... on the dose and lipophilicity of the opioid administered. 12 , 20 , 21 Dose-response relationships between spinal morphine, analgesic duration, and pruritus have indicated that escalating doses of morphine improve analgesia but are correlated with higher incidences and severity of pruritus. 22 , 23...
Articles
Publication: Anesthesiology
Anesthesiology. July 2021: 135(1):69–82
Published: July 2021
...). The authors declare no competing interests. References 1. Angst MS , Ramaswamy B , Davies MF , Maze M : Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans. A nesthesiology . 2004 ; 101 : 744 – 52 2...
Articles
Publication: Anesthesiology
Anesthesiology. March 2021: 134(3):421–434
Published: March 2021
... clinical staff on all weekdays, at all hours, to minimize the risk of selection bias. Figure 1 depicts the study flow diagram for the analytical sample of the current paper. Given that the cohort consisted of multiple surgical services, it was not possible to consider a universal analgesic strategy...
Articles
Publication: Anesthesiology
Anesthesiology. December 2020: 133(6):1283–1305
Published: December 2020
..., it is important that acute hypertension be promptly controlled. Control of headache with analgesics, anxiolysis and bed rest is important. According to the American Heart Association/American Stroke Association guidelines, strict control of blood pressure is necessary after aneurysmal subarachnoid hemorrhage. 63...
Articles
Publication: Anesthesiology
Anesthesiology. May 2020: 132(5):1229–1234
Published: May 2020
...” analgesics for anesthesiologists consisted of fentanyl, discovered by Paul Janssen, M.D., founder of Janssen Pharmaceutica in Beerse, Belgium, and approved for use in 1968, along with sufentanil and alfentanil, both discovered by Janssen et al. and approved for clinical use in the mid-1980s ( fig. 1...
Articles
Publication: Anesthesiology
Anesthesiology. July 2020: 133(1):154–164
Published: July 2020
... Ketamine is often used for the management of refractory chronic pain. There is, however, a paucity of trials exploring its analgesic effect several weeks after intravenous administration or in association with magnesium. The authors hypothesized that ketamine in neuropathic pain may provide pain relief...
Articles
Publication: Anesthesiology
Anesthesiology. May 2020: 132(5):981–991
Published: May 2020
..., several additional variables were included as covariates in the regression models. Intraoperative opioids including morphine, fentanyl, alfentanil, and an indicator for whether remifentanil was administered were included as covariates. Preoperative gabapentin use (less than 3% incidence), intraoperative...
Articles
Publication: Anesthesiology
Anesthesiology. March 2020: 132(3):491–503
Published: March 2020
.... Fentanyl plasma concentrations, pupil diameter, analgesic response to experimental pain (cold pressor), subjective side effects, and cognitive effects were measured. Plasma fentanyl concentrations and changes in pupil diameter were subjected to pharmacokinetic–pharmacodynamic modeling. Results St. John’s...
Articles
Publication: Anesthesiology
Anesthesiology. March 2020: 132(3):571–580
Published: March 2020
... in postbaseline measurements in both treatment branches. Baseline cortisol was not associated with the placebo effect or strength applied of current to reach defined pain ratings. Conclusions Open label placebos might play a role in multimodal analgesic concepts. Editor’s Perspective What We Already Know about...
Articles
Publication: Anesthesiology
Anesthesiology. December 2019: 131(6):1327–1339
Published: December 2019
... depression induced by the activation of the μ-opioid receptor. In this study in healthy volunteers, we assessed the respiratory and analgesic effects of R-7,8-dihydro-7α-[1-( R )-hydroxy-1-methylbutyl]-6,14- endo -ethanotetrahydro-oripavine (R-dihydroetorphine; fig. 1 ), an opioid with full agonism...
Articles
Publication: Anesthesiology
Anesthesiology. November 2019: 131(5):1004–1017
Published: November 2019
... . Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans A nesthesiology . 2004 ; 101 : 744 – 52 21. Bouillon TW , Bruhn J , Radulescu L , Andresen C , Shafer TJ , Cohane C , Shafer SL...