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Anesthetics, intravenous: alfentanil

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Articles
This article has a Visual Abstract This article has an Audio Podcast
Publication: Anesthesiology
Anesthesiology. June 2024: 140(6):1076–1087
Published: June 2024
... a role in this process. 9 Hypoxia is a common occurrence in postoperative patients and those undergoing sedation for minor procedures. 10 The causes of hypoxia vary, but impairment of ventilatory control by anesthetic agents, such as inhalational and intravenous anesthetics, can...
Articles
CME Article
Publication: Anesthesiology
Anesthesiology. March 2024: 140(3):409–416
Published: March 2024
.... Vinik HR , Bradley EL , Jr. , Kissin I : Midazolam–alfentanil synergism for anesthetic induction in patients. Anesth Analg 1989 ; 69 : 213 – 7 16. Loscalzo LM , Wasowski C , Paladini AC , Marder M : Opioid receptors are involved in the sedative...
Articles
Publication: Anesthesiology
Anesthesiology. January 2024: 140(1):157–163
Published: January 2024
... index of less than 35 kg/m 2 who had total intravenous anesthesia with an endotracheal tube, neuromuscular blockade with rocuronium, and surgery lasting at least 1 h. A total of 4,584 anesthetics met these inclusion criteria. We further reduced the data set by focusing on the propofol target...
Articles
Publication: Anesthesiology
Anesthesiology. March 2023: 138(3):249–263
Published: March 2023
... of intravenous 0.5 or 2 mg oliceridine and 2 or 8 mg morphine in 18 healthy male and female volunteers, aged 55 to 89 yr, on four separate occasions. Participants’ CYP2D6 genotypes were determined, hypercapnic ventilatory responses were obtained, and arterial blood samples were collected before and for 6 h after...
Articles
This article has a Video Abstract
Publication: Anesthesiology
Anesthesiology. June 2022: 136(6):985–996
Published: June 2022
... anesthesia, as well as intravenous anesthesia, and with or without opioids or other intravenous anesthetics or adjuvants. Disadvantages include the proprietary algorithms, the processing delay, and the lack of exact thresholds that guarantee unconsciousness. Although MAC itself is not quantal...
Articles
Publication: Anesthesiology
Anesthesiology. June 2022: 136(6):888–900
Published: June 2022
... methods. Lumbar epidural analgesia using local anesthetics was the primary technique during my medical training, but case reports of untreatable cardiac arrest 4 and paralysis 5 appeared, leading to new Food and Drug Administration (Silver Spring, Maryland) regulations and drug withdrawals. Also...
Articles
Publication: Anesthesiology
Anesthesiology. April 2022: 136(4):618–632
Published: April 2022
..., Cotten’s research group studied the effect of thyrotropin-releasing hormone and taltirelin on opioid-induced respiratory depression in the rat. 26 , 27 Intravenous thyrotropin-releasing hormone and taltirelin reversed morphine-induced respiratory depression in the isoflurane-anesthetized rat. Reversal...
Articles
This article has a Visual Abstract
Publication: Anesthesiology
Anesthesiology. May 2022: 136(5):792–801
Published: May 2022
... -norketamine had a small antagonistic effect for both endpoints. Ketamine is a versatile drug that is used by anesthesiologists, pain physicians, and more recently by psychiatrists. 1 At high doses, ketamine produces a dissociative anesthetic state; at low (subanesthetic) doses, it produces...
Articles
Publication: Anesthesiology
Anesthesiology. January 2022: 136(1):176–180
Published: January 2022
... volatile anesthetic (isoflurane/nitrous oxide), a pure intravenous anesthetic (propofol/fentanyl), and a “default” fentanyl/nitrous oxide/low-dose volatile anesthetic, as in our previous project. 3 This time, in addition to the standard clinical assessments, we were able to measure ICP at the time...
Articles
Publication: Anesthesiology
Anesthesiology. August 2021: 135(2):350–365
Published: August 2021
... opioid administration, which comprised 2.6% of all cases of anaphylaxis caused by anesthetics. 63 For these reasons, MRGPRX2 should be considered a target for IgE-independent allergic reactions to perioperative drugs such as morphine administered subcutaneously and intravenously. Opioid-induced...
Articles
Publication: Anesthesiology
Anesthesiology. July 2021: 135(1):69–82
Published: July 2021
... anesthetics, at sedative doses, in an experimental memory paradigm using periodic pain. The primary outcome, recollection memory performance, was quantified with d ′ (a difference of z scores between successful recognition versus false identifications). Secondary outcomes were familiarity memory performance...
Articles
Publication: Anesthesiology
Anesthesiology. March 2021: 134(3):421–434
Published: March 2021
... for nerve block placement generally consisted of 1 to 5 mg of midazolam and up to 1,000 μg of alfentanil, titrated ideally to anxiolysis. Select candidates for orthopedic surgery received neuraxial anesthetics with sedation maintained with propofol for lower extremity procedures, and distal upper extremity...
Articles
Publication: Anesthesiology
Anesthesiology. December 2020: 133(6):1283–1305
Published: December 2020
... hemodynamic stability; (5) provide neuroprotection; (6) not interfere with neurophysiological monitoring, and; (7) be easily titrated to the required anesthetic depth allowing rapid emergence. Obviously, a single agent with all these properties does not exist. Intravenous and inhaled anesthetic agents differ...
Articles
Publication: Anesthesiology
Anesthesiology. July 2020: 133(1):154–164
Published: July 2020
... Ketamine is often used for the management of refractory chronic pain. There is, however, a paucity of trials exploring its analgesic effect several weeks after intravenous administration or in association with magnesium. The authors hypothesized that ketamine in neuropathic pain may provide pain relief...
Articles
Publication: Anesthesiology
Anesthesiology. June 2020: 132(6):1317–1332
Published: June 2020
..., and bucking should be applied. Appropriate levels of sedation, such as dexmedetomidine (0.4 mcg · kg -1 · h -1 ) 23 or remifentanil (1 to 4 ng/ml target organ concentration) 24 infusion, should be considered. Intravenous lidocaine (1 to 1.5 mg/kg) is effective for cough reduction. 25 , 26 Alfentanil...
Articles
Publication: Anesthesiology
Anesthesiology. May 2020: 132(5):981–991
Published: May 2020
... 15,010 patients who received intraoperative hydromorphone as part of an anesthetic at the University of California, Los Angeles hospitals from February 2016 to March 2018. Before July 2017, hydromorphone was available as a 2-mg unit dose. From July 1, 2017 to November 20, 2017, hydromorphone was only...
Articles
Publication: Anesthesiology
Anesthesiology. April 2020: 132(4):652–666
Published: April 2020
... : Exploratory Data Analysis Addison-Wessley Publishing Company , 1977 15. Hughes MA , Glass PS , Jacobs JR : Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs. A nesthesiology 1992 ; 76 : 334 – 41 16. Kuizenga K...
Articles
Publication: Anesthesiology
Anesthesiology. March 2020: 132(3):491–503
Published: March 2020
... One study found that as many as 70% of patients taking herbal supplements were not forthcoming about their use during preoperative evaluation. 2 Presurgical use of herbal therapy, together with multiple drug use during anesthesia, presents a high potential for adverse herb–anesthetic interaction...
Articles
Publication: Anesthesiology
Anesthesiology. November 2019: 131(5):1004–1017
Published: November 2019
... ; 23 : 301 – 7 11. Peden CJ , Cloote AH , Stratford N , Prys-Roberts C . The effect of intravenous dexmedetomidine premedication on the dose requirement of propofol to induce loss of consciousness in patients receiving alfentanil Anaesthesia . 2001 ; 56 : 408 – 13...
Articles
This article has a Visual Abstract This article has an Audio Podcast
Publication: Anesthesiology
Anesthesiology. December 2019: 131(6):1223–1238
Published: December 2019
... Observer’s Assessment of Alertness/Sedation (MOAA/S) scale Anesthetic drug effects between and within individuals can also be quantified using processed, electroencephalographic-derived indices. 9 The Patient State Index (Masimo, USA) is such an index and is calculated by a proprietary algorithm...