..., Maryland) grants R01 NS109255, grant R01 NS106902 from the National Institute of Neurological Disorders and Stroke (Bethesda, Maryland), and grant P30DA051355 from the National Institute on Drug Abuse (Bethesda, Maryland). Dr. Roberts is a paid consultant for Neumora (Watertown, Massachusetts) and has...

..., neurocognitive tests, cold pressor test, and plasma drug concentrations were obtained at regular intervals. Population pharmacokinetic–pharmacodynamic analyses served as the basis for construction of a utility function, which is an objective function of probability of benefit minus probability of harm...

... pharmacologic and pathologic interactions including anesthetic drugs. Phase-contrast magnetic resonance imaging enables fast and accurate quantitative measurement of blood flow. It is currently the reference standard for noninvasive intravascular flow measurements 11 and useful in experimental settings...

... as previously described 9 , 10 ( appendix 1 ): (1) use of multimodal anesthesia (including peripheral nerve block, nonsteroidal anti-inflammatory drugs, cyclooxygenase-2 inhibitors, paracetamol or acetaminophen, gabapentin or pregabalin, or ketamine) on the day of surgery or postoperative day 1, (2) use...

... interactions. 7 , 9 Talbot et al. suggested that ablating Nav1.8(+) sensory neurons or silencing them substantially could reduce pathogen-induced airway infiltration of macrophages and bronchial hyperresponsiveness. 35 It has also been proven that peripheral noxious stimuli induce an abnormal...

...-inflammatory drugs (NSAIDs), diuretics, and intravascular contrast agents ( table 2 ). Commonly used antibiotics, including aminoglycosides, β-lactams, and vancomycin, mediate AKI through immune and nonimmune mechanisms. Aminoglycosides accumulate in proximal tubular cells and cause apoptosis and acute tubular...

... also treating hypotension. 9 Therefore, both drugs correct hypotension, but ephedrine may retain better cerebral perfusion. We tested the research hypothesis that intraoperative administration of phenylephrine for treating intraoperative hypotension, compared to ephedrine, is associated...

... and the development of polygenic risk scores. An important element to consider is how nongenetic and nonsurgical factors interact with genetic influences on the development of postsurgical pain. Patient age, body mass index, and psychologic factors such as preoperative anxiety and catastrophizing have all been...

... The drug effect was then modified using a competitive interaction model. For RO48-6791, the hypothetical tolerance compartment followed the pharmacokinetic behavior of the metabolite, and therefore tolerance was also described using a model where the metabolite concentration of RO48-6791 was driving...

... occurred ( both handover The association of study outcomes and type of handover was performed using IPTW analysis for each handover type. Second, we investigated the interaction of handovers for different study outcomes using the IPTW and further adjusted for anesthesia duration and anesthesia start hour...

... All individual pain scores are presented in figure 3 , while the worst and resting numerical rating scale scores at each time point are shown in Supplemental Figure 1 ( https://links.lww.com/ALN/D236 ). The general linear model detected a significant effect of the group-by-time interaction...

... tactile allodynia, conditioned place aversion, and memory deficits and decreased the excitability of pyramidal neurons in naive mice. ( A ) Changes in the tactile threshold in the hind paw (contralateral to the drug injection) of naive mice after 1,4-dideoxy-1,4-imino- d -arabinitol or saline...

... concentrations, the major determinants of the noncarbonic buffer power. 4 Nevertheless, they are commonly applied to critically ill patients, in whom these factors are often altered by acute illness, drug administration, or intravenous fluid infusion. 5 , 6 Third, they do not give any insight...

... of machine learning. The United Kingdom Department of Health and Social Care issued a code of conduct in 2018, while the U.S. Food and Drug Administration has developed a regulatory framework and action plan. The primary aim of these initiatives is to establish a reliable structure that ensures secure...

... model. This model incorporated coefficients for the interaction between indicators representing the lead or lag time for each quarter relative to the reference quarter ( i.e. , the quarter immediately before enactment of the law) and an indicator for whether the payment was for an anesthesia procedure...

... (95%CI 1.90, 1.78) bpm / (1%ET). The interaction terms were also significant though with smaller coefficients. With mean 12 Accepted Preproof individual heart rate included as a regressor, no demographic parameters were significant, suggesting that the drug effects on the heart rate may...

... lower pain scores 3 h after consumption than both meperidine and hydromorphone. This trend continued as 48.9% of patients had no pain 19 h and longer after lysergic acid diethylamide-25 administration (compared to 0% in the other two drug groups). A later case-report of a patient (n = 1) with depression...

... of 10 μl/g of body weight. Anesthesia was maintained with isoflurane 1.5 to 2 vol% in 30% oxygen. Fluid-filled microcatheters (PE-10, Becton Dickinson, USA) were inserted into the left femoral artery and vein, respectively, for monitoring blood pressure and for drug administration. Invasive blood...

... Copyright © 2023 American Society of Anesthesiologists. All Rights Reserved. Unauthorized reproduction of this article is prohibited Accepted Preproof diagnosis to surgery, and their interaction. Length of time from diagnosis to surgery was binned into two-week segments: 0-2 weeks, 2-4 weeks, 4-6 weeks, 6-8...

..., inotropic drugs and vasopressors (including dobutamine, dopamine, milrinone, epinephrine, and norepinephrine) remain the first-line treatment for primary graft dysfunction. These medications may potentially be combined with vasopressin and inhaled nitric oxide 8 (see figure in Supplemental Digital...