Todd C. Sacktor, M.D. will present the Severinghaus Lecture at the ANESTHESIOLOGYTM2013 annual meeting in San Francisco this October.

Dr. Sacktor, a Distinguished Professor of Physiology, Pharma-cology and Neurology at SUNY Downstate Medical Center, worked for 20 years on the molecular mechanisms of long-term memory storage. He discovered an isoform of protein kinase C, called PKMζ, which appears to have remarkable properties that allow it to store long-term memories. Inhibiting PKMζ erases old memories, and increasing the kinase enhances them. Next door was the laboratory of Ira Kass, Professor of Anesthesiology and Physiology and Pharmacology, and Jim Cottrell, Distinguished Professor and Chairman of the Department of Anesthesiology. While discussing science in the hallway, the three decided to look at the role of PKMζ in anesthesia. Together, they found that PKMζ plays a critical role in anesthesia-induced preconditioning....

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