Kidney transplantation is limited by available organs. The use of organs from human leukocyte antigen (HLA)-incompatible living donors would potentially increase the available organ pool. According to a recent retrospective matched-cohort study, patients receiving an incompatible live-donor kidney after desensitization were most likely to demonstrate which of the following compared to patients remaining on the waiting list or receiving a deceased-donor transplant?

Kidney transplantation remains the preferred treatment for end-stage renal disease. Ideally, the donor organs are selected for the recipient using human leukocyte antigen (HLA) matching. However, many patients develop anti-HLA antibodies, making matching difficult or impossible. These patients can undergo a desensitizing protocol and then receive an HLA-incompatible kidney from a live donor. Questions remain regarding the outcomes of patients who receive incompatible organs, as these patients do worse than those receiving matched organs, but outcomes may...

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