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For patients with chronic cancer-related pain who are receiving long-acting opioids, breakthrough pain may be targeted with one of the newer rapid-onset, transmucosal immediate release fentanyl (TIRF) formulations, which are specifically indicated for opioid-tolerant cancer patients. In the United States, all of these products, including generics, have a mandatory shared risk evaluation and mitigation strategy, the purpose of which is to reduce the risk of misuse and unintentional overdose. Because of...

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