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Table 1. Pharmacokinetic Parameters of M6G and Morphine Used for Dosage Calculation

Pharmacokinetic parameters of M6G and morphine used to calculate the doses to achieve predefined target plasma concentrations. Both morphine and M6G plasma concentrations are described by standard two-compartment models. CL = body clearance; Q = intercompartment clearance; V1 and V2 = volume of distribution of compartments 1 and 2, respectively. The parameters of the pharmacokinetic model were estimated by a naïve pooled NONMEM analysis of a data set that was available from a previous investigation with administration of M6G and morphine to healthy men. 13 

Table 1. Pharmacokinetic Parameters of M6G and Morphine Used for Dosage Calculation
Table 1. Pharmacokinetic Parameters of M6G and Morphine Used for Dosage Calculation
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