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Table 1. Standardized Population Pharmacokinetic Parameter Estimates

%CV is the coefficient of variation for the population parameter estimate, except for Vstdand CLstd, where between subject (BSV) and between occasion variability (BOV) were estimated.

CLstd= population estimate for CL/Foral; CL/Foral = clearance after oral administration (l · h−1· 70 kg−1); Vstd= population estimate for V/Foral; V/Foral = volume of distribution (l/70 kg); Tabs = absorption half-life after nasogastric (elixir) in children out of the neonatal period; triglyceride base suppository and capsule suppository administration (h); Tlag = absorption lag time after nasogastric (elixir), triglyceride base suppository and capsule suppository administration (h); Frectal/oral = relative bioavailability of the rectal compared to the oral formulation at 28 weeks postconception age (PCAGE).

Table 1. Standardized Population Pharmacokinetic Parameter Estimates
Table 1. Standardized Population Pharmacokinetic Parameter Estimates
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