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Table 2. Covariate Models and Estimates for Pooled Population Parameters

βvol and βcl = parameters estimating the fraction above or below V/Foral and CL/Foral, respectively, at 28 weeks’ postconception age (PCAGE); Tvol and Tcl = the maturation half-lives of the age-related changes of V/Foral and CL/Foral; βabs = a parameter estimating the fraction above Tabs at birth; Telix = the maturation half-life of the postnatal age-related change in oral absorption in weeks.

V/Foral = volume of distribution (l/70 kg); CL/Foral = clearance after oral administration (l · h−1· 70 kg−1).

Table 2. Covariate Models and Estimates for Pooled Population Parameters
Table 2. Covariate Models and Estimates for Pooled Population Parameters
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