Table 4. MAC-awake of Xenon and N2O Administered in Combination with the 0.5-MAC-awake Concentrations of Isoflurane or Sevoflurane
The values predicted assuming additivity were calculated by multiplying the minimum alveolar concentration (MAC)-awake of xenon and nitrous oxide (N2O) presented in table 3by 0.5 because the assumption of additivity between xenon or N2O and isoflurane or sevoflurane predicts that the addition of the 0.5 MAC-awake concentrations of these volatile anesthetics would halve the MAC-awake of xenon and N2O. These predicted values were then compared to those determined in the presence of isoflurane or sevoflurane.
*P < 0.01 versus the value predicted assuming additivity, analysis of variance and Dunnett test, indicating infraadditivity between N2O and isoflurane or sevoflurane.