Table 3. Hemodynamic Measurements: Intratracheal Scavenger Group
Hemodynamic parameters before (baseline) and 5 min after left mainstem bronchus occlusion (LMBO). Mice were challenged with intraperitoneal saline or endotoxin (lipopolysaccharide) 22 h before hemodynamic measurements. Control mice received saline, N -acetylcysteine, or EUK-8 intratracheally 1 h after saline challenge. Mice in the endotoxin group received intratracheal saline (lipopolysaccharide + saline), N -acetylcysteine (lipopolysaccharide +N -acetylcysteine) or EUK-8 (lipopolysaccharide + EUK-8) 1 h after endotoxin challenge.
All values at baseline and LMBO were compared between saline-challenged mice and endotoxin-challenged mice:*P < 0.05, †P < 0.01, ‡P < 0.001 versus corresponding control; §P < 0.05 versus endotoxin. The effect of LMBO on each parameter was analyzed in each group:P < 0.05, #P < 0.01, **P < 0.001 versus baseline.
HR = heart rate; SAP = mean systemic arterial pressure; PAP = mean pulmonary artery pressure; QLPA = flow through left pulmonary artery; bw = body weight; LPVR = left pulmonary vascular resistance.