Table 1. Effects of Atracurium at α4β2, α3β4, α3β4α5, and α7 nAChRs
Acetylcholine (ACh) concentration of half activation (EC50) measured in control and during atracurium exposures (10 or 5 μm) are given. Mean and SD values corresponding to the best fits obtained with the empirical equation (1)are indicated. Atracurium concentration–response inhibition curves, measured as in figure 2A, were characterized with their respective concentration of half inhibition (IC50) values. Mean and SD values obtained by curve-fitting with the Hill equation (2)are indicated. Numbers in parentheses indicate the number of cells tested in each condition. No statistical difference was observed in EC50, IC50, and Hill coefficient between α3β4 and α3β4α5.
cDNA = complementary DNA; nAChR = neuronal nicotinic acetylcholine receptor; nH = apparent cooperativity.
