American Society of Anesthesiologists

Fig. 3. Effects of nitric oxide (NO) synthase inhibition (l-NAME, 10−4m), calcium-activated potassium (KCa) channel inhibition (TBA, 10−3m), alone and in combination, on the relaxant response to acetylcholine (A ), bradykinin (B ), and A23187 (C ) in rings pretreated with ibuprofen (IBU, 10−5m). Pulmonary arterial rings were precontracted to the ED50level of tension with phenylephrine. l-NAME alone and TBA alone inhibited the relaxant responses to these three endothelial activators, whereas combined inhibition abolished the responses (* P < 0.05, ** P < 0.01, compared with respective control; ##P < 0.01 compared with rings pretreated with l-NAME plus ibuprofen in each group).

Fig. 3. Effects of nitric oxide (NO) synthase inhibition (l-NAME, 10⁻⁴m), calcium-activated potassium (KCa) channel inhibition (TBA, 10⁻³m), alone and in combination, on the relaxant response to acetylcholine (A ), bradykinin (B ), and A23187 (C ) in rings pretreated with ibuprofen (IBU, 10⁻⁵m). Pulmonary arterial rings were precontracted to the ED⁵⁰level of tension with phenylephrine. l-NAME alone and TBA alone inhibited the relaxant responses to these three endothelial activators, whereas combined inhibition abolished the responses (* P < 0.05, ** P < 0.01, compared with respective control; ^##P < 0.01 compared with rings pretreated with l-NAME plus ibuprofen in each group).

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