![Fig. 6. Changes in intracellular calcium concentration ([Ca2+]i) (340/380 ratio) of cultured bovine pulmonary artery endothelial cells in response to consecutive applications of bradykinin (10−8m) in the absence (A ) or presence of anesthetic (B ) (n = 6 each). Peak and sustained increases in [Ca2+]iin response to the second application of bradykinin were expressed as a percentage of the first response. Etomidate (10−4m) and ketamine (10−4m) attenuated both the peak and sustained increases in endothelial [Ca2+]iin response to bradykinin (C ) (* P < 0.05, ** P < 0.01, compared with control).](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/94/4/10.1097_00000542-200104000-00022/2/22ff6.png?Expires=1716639827&Signature=R1Y2Oygtb8tVSq3QmIQixfdHLyY0S6UmpAlptiCCDdRm20XacM1ZVoGIf9EpUknJpKWV6UURN7jFM~9eWcY7g8tk-wJe~oH72DBXRdRAomaCyjWTvtf0v4gME9Pt4sg9AOiQO84GXlq2yxBKrd6uaQCHRTdbSOf89Y~hhMQbqjX94H9s~uhFtGeLo61F7RM9zu1JsNSHJ3QkiV1Sf-HTBHfsSgMwaJecFzrl-jlSsIJL7ZJ9DO1VmHQgX7XmThQpf6IXlzQfRVPYUSAkdMLfgwvlenGGsTEJge27hrfSGasxalQK225wWkSSjZi5~Pciz8lFRljB8GPOSgFRai9YVA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fig. 6. Changes in intracellular calcium concentration ([Ca2+]i) (340/380 ratio) of cultured bovine pulmonary artery endothelial cells in response to consecutive applications of bradykinin (10−8m) in the absence (A ) or presence of anesthetic (B ) (n = 6 each). Peak and sustained increases in [Ca2+]iin response to the second application of bradykinin were expressed as a percentage of the first response. Etomidate (10−4m) and ketamine (10−4m) attenuated both the peak and sustained increases in endothelial [Ca2+]iin response to bradykinin (C ) (* P < 0.05, ** P < 0.01, compared with control).
