Fig. 5. Morphine antinociceptive responses in μ-opioid receptor (OR)−/−(open circles) and μOR+/+(closed circles) mice (0 mg/kg morphine = NaCl 0.9%). (A ) Hot-plate test; (B ) tail-immersion test. Values on the y -axis represent the latencies in seconds of the nociceptive thresholds. Cutoff latencies were 30 s for the hot-plate test and 15 s for the tail-immersion test. Values are mean ± SD. * P < 0.05 versus  saline and μOR knockout mice (two-way analysis of variance).

Fig. 5. Morphine antinociceptive responses in μ-opioid receptor (OR)−/−(open circles) and μOR+/+(closed circles) mice (0 mg/kg morphine = NaCl 0.9%). (A ) Hot-plate test; (B ) tail-immersion test. Values on the y -axis represent the latencies in seconds of the nociceptive thresholds. Cutoff latencies were 30 s for the hot-plate test and 15 s for the tail-immersion test. Values are mean ± SD. * P < 0.05 versus  saline and μOR knockout mice (two-way analysis of variance).

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