Fig. 1. Mean arterial pressure (MAP), heart rate, cardiac index, and systemic vascular resistance (SVR). Each variable was recorded every 15 min before and after administration of CNS 5161A. Data are presented at minimum alveolar concentration and as mean ± SD. Isoflurane at minimum alveolar concentration significantly decreased all hemodynamic parameters compared with CNS 5161A alone (P < 0.01). There was no significant difference in any of the hemodynamic parameters with CNS 5161A alone versus  control (animal awake). Baseline values in awake animals were as follows: MAP, 101.5 ± 8 mmHg; HR, 164.8 ± 9 beats/min; CI, 6.6 ± 1 l · min⁻¹· m⁻²; and SVR, 4,795 ± 578 dyn · s⁻¹· cm⁻⁵.