Fig. 1. Deoxyribonucleic acid strand breaks as assessed by TUNEL staining using horseradish peroxidase with TACS Blue labeling and Red Counterstain C staining of myocytes grown on coverslips. (A ) Mean percentages of TUNEL-positive myocytes exposed to norepinephrine (NE; 10 μm) for 3, 6, 12 and 24 h. Data are mean ± SD. *P < 0.0001 versus  time control. (B ) Mean percentages of TUNEL-positive myocytes exposed to NE (10 μm) alone or in presence of diltiazem (DIL; 1 μm), propranolol (PRO; 2 μm), and increasing concentrations of isoflurane (ISO; 0.4, 0.8, and 1.6 MAC) and halothane (HAL; 0.3, 0.6, and 1.2 MAC) for 12 h. Data are mean ± SD. *P versus  NE, †not significant versus  control (CTL).

Fig. 1. Deoxyribonucleic acid strand breaks as assessed by TUNEL staining using horseradish peroxidase with TACS Blue labeling and Red Counterstain C staining of myocytes grown on coverslips. (A ) Mean percentages of TUNEL-positive myocytes exposed to norepinephrine (NE; 10 μm) for 3, 6, 12 and 24 h. Data are mean ± SD. *P < 0.0001 versus  time control. (B ) Mean percentages of TUNEL-positive myocytes exposed to NE (10 μm) alone or in presence of diltiazem (DIL; 1 μm), propranolol (PRO; 2 μm), and increasing concentrations of isoflurane (ISO; 0.4, 0.8, and 1.6 MAC) and halothane (HAL; 0.3, 0.6, and 1.2 MAC) for 12 h. Data are mean ± SD. *P versus  NE, †not significant versus  control (CTL).

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