Fig. 9. Histologic assessment of the antiinflammatory effects of κ-opioid treatment and antagonism by nor-BNI (200 μg intraplantarly) or naloxone methiodide (NLXM; 10 mg/kg). Histologic scores judged by periarticular inflammtion, pannus, and new bone formation (maximum obtainable score = 24). *Significant difference from controls, P < 0.05, analysis of variance (Dunnett test).