Table 1. Shifts in Steady-state Inactivation V^1/2(Δ mV) of I^Ca,Land I^Ca,T

Summary of the effects of isoflurane on steady-state inactivation of the Ca²⁺channel currents in atrial and ventricular cells. Data are mean ± SEM of changes in V^1/2from control for the different doses of isoflurane. The changes are denoted as Δ mV. Control V^1/2(half maximal voltage) values of −57.4 ± 0.6, −15.1 ± 0.6, and −14.9 ± 0.3 mV were obtained for atrial T-, L-, and ventricular L-type Ca channels (I^Ca,T,I^Ca,L), respectively. The slope factors k were not significantly affected by isoflurane (see Results).

* Values are significantly different (P < 0.05) from control.

† Significant difference in the hyperpolarizing shift in steady-state inactivation from atrial T- and ventricular L-type Ca channels.

‡ Significant (P < 0.05) differences in the hyperpolarizing shift in steady-state inactivation from atrial T-type Ca channels.