Fig. 6. Isoflurane induced shifts in reversal potential. (A ) Dose-dependent effects of isoflurane on the apparent reversal potential (E^rev) in atrial (shaded gray) and ventricular (hatch bars) L-type Ca²⁺channel currents are shown. The average E^revfor the atrial and ventricular L-type calcium channels were 59.7 ± 2.3 and 59.1 ± 0.7 mV, respectively; shifts in reversal potential are depicted as ΔE^revfrom control. *Significantly different (P < 0.05) from control. (B) Increased extracellular Ca²⁺concentration attenuates the magnitude of shift in E^revinduced by 0.9 mm isoflurane. #Shift in E^revis significantly (P ≤ 0.05) less when compared with 2 mm extracellular Ca²⁺. #Significant difference between 10 and 20 mm extracellular Ca²⁺in reducing isoflurane-induced hyperpolarizing shift in E^rev.