Table 4. ED50Values (mg/kg) of Morphine (MS), Clonidine (CL), and Their 1:1 Combination (MS + CL) in Controls (SS) and Mice with Intestinal Inflammation (INF); Type of Interaction of the Morphine–Clonidine Combination at the ED50
ED50values were obtained from the linear segments of the log dose–response curves shown in figure 5. Synergy and antagonism represent statistically significant deviations from additivity. The numbers in parentheses are the values of the interaction indexes.
*P < 0.05 (Student t test).
**P < 0.01 (Student t test).