Fig. 3. Hind paw withdrawal threshold over time in rats receiving intraperitoneal injections of the allosteric adenosine receptor modulator T62, 15 mg/kg, alone (▪) or preceded by intrathecal (i.t.) injection of 9 μg of the A1 adenosine receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX, •). Data are median ± 25th and 75th percentiles. * P < 0.05 compared with preinjection value. Groups differ by two-way analysis of variance. s.c. = subcutaneous.