Fig. 1. (Top ) The influence of plasma alfentanil concentration (x-axis) at fixed concentrations of end-tidal sevoflurane concentration (ETSEVOFLURANE) on the hypoxic drive or ΔV̇1/ΔSpo2(y-axis) in one subject (subject 926). Note the parallel displacements of the alfentanil dose–hypoxic response curve caused by sevoflurane. (Bottom ) A three-dimensional graph of the individual Bayesian estimate of the response surface of subject 926 for ΔV̇i/ΔSpo2. The open and closed circles denote data points above and below the surface, respectively. The surface gives an impression of the nature of the interaction at all possible drug combinations, which, in this case, is additive. (Inset ) A slice through the surface representing the concentrations of alfentanil and sevoflurane causing 25% depression of V̇i. Calf= alfentanil blood concentration.

Fig. 1. (Top ) The influence of plasma alfentanil concentration (x-axis) at fixed concentrations of end-tidal sevoflurane concentration (ETSEVOFLURANE) on the hypoxic drive or ΔV̇1/ΔSpo2(y-axis) in one subject (subject 926). Note the parallel displacements of the alfentanil dose–hypoxic response curve caused by sevoflurane. (Bottom ) A three-dimensional graph of the individual Bayesian estimate of the response surface of subject 926 for ΔV̇i/ΔSpo2. The open and closed circles denote data points above and below the surface, respectively. The surface gives an impression of the nature of the interaction at all possible drug combinations, which, in this case, is additive. (Inset ) A slice through the surface representing the concentrations of alfentanil and sevoflurane causing 25% depression of V̇i. Calf= alfentanil blood concentration.

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