Table 2. The Population Pharmacokinetic Model of Alfentanil (± SE) with Mean Arterial Pressure as Covariate

The coefficient of variation was calculated as the square root of the variance of η. With α= 0, mean arterial pressure is not a significant covariate.

CV = coefficient of variation; V¹= central volume of distribution; V²= small peripheral volume of distribution; V³= large peripheral volume of distribution; Cl¹= elimination clearance; Cl²= rapid distribution clearance; Cl³= slow distribution clearance; t^lag= lag time.