American Society of Anesthesiologists

Fig. 5. Effects of propofol on depolarization-induced whole cell inward Ba2+currents (IBa). (A ) Typical recordings of IBainduced by pulses to +10 mV without or with propofol (10−4m). The dashed line denotes zero current. (B ) The relation between peak whole cell IBaand applied potential before (filled circles) and after (open circles) exposure to propofol. (C ) The relation between peak IBaat +10 mV, expressed as a percentage of control, and the propofol concentrations in the bath. Propofol significantly inhibited peak IBaat +10 mV in a dose-dependent manner, and there was no apparent shift in the voltage dependence of IBawith propofol. Symbols represent mean ± SD (n = 6 at each point). *P < 0.05, **P < 0.01 versus control without propofol.

Fig. 5. Effects of propofol on depolarization-induced whole cell inward Ba²⁺currents (I^Ba). (A ) Typical recordings of I^Bainduced by pulses to +10 mV without or with propofol (10⁻⁴m). The dashed line denotes zero current. (B ) The relation between peak whole cell I^Baand applied potential before (filled circles) and after (open circles) exposure to propofol. (C ) The relation between peak I^Baat +10 mV, expressed as a percentage of control, and the propofol concentrations in the bath. Propofol significantly inhibited peak I^Baat +10 mV in a dose-dependent manner, and there was no apparent shift in the voltage dependence of I^Bawith propofol. Symbols represent mean ± SD (n = 6 at each point). *P < 0.05, **P < 0.01 versus control without propofol.

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