Fig. 6. Endogenous analgesia during inflammation. Paw pressure thresholds are given as raw values (n = 6 per group, mean ± SD). Values in inflamed (filled circle) and noninflamed paw (open square) before (baseline [BL]) and 1 min after cold water swim stress (CWS) are shown. CWS-induced endogenous analgesia increased steadily during the course of inflammation (P < 0.01 by analysis of variance).