Fig. 1. (A ) The traditional management of traumatic brain injury involves a stair-step addition of treatments as necessary to control intracranial pressure (ICP). CSF = cerebrospinal fluid. (B ) The cerebral perfusion pressure (CPP) management strategy is based on the vasodilatory cascade (from Rosner et al. 2). Increasing blood pressure breaks the vasodilatory stimulus for intracranial hypertension. SBP = systolic blood pressure; CBF = cerebral blood flow; CBV = cerebral blood volume. (C ) The Lund strategy is based on knowledge of the forces that govern transcapillary filtration of fluid. Reduction in the hydrostatic pressure in the capillaries reduces edema formation and therefore lowers ICP. Jv= transcapillary filtration of fluid; Kf= filtration coefficient; (Pc− Pi) = hydrostatic pressure difference between plasma and interstitial fluid; (πp−πi) = oncotic pressure difference between plasma and interstitial fluid; ς= solute reflection coefficient.