Fig. 3. Regression analysis of plasma osmolality and brain water for mannitol (○) and mannitol with furosemide (▪). Brain water content correlated with plasma osmolality in both the mannitol groups (brain water %= 87.599–0.030 × plasma osmolality; r2= 0.869) and the mannitol with furosemide groups (brain water %= 89.335–0.036 × plasma osmolality; r2= 0.956). The slope of the mannitol-with-furosemide line is numerically greater (0.036) than for mannitol alone (0.030), although this did not achieve statistical significance (P = 0.05).