Fig. 9. (A ) ω-Agatoxin IVA did not affect bupivacaine anesthesia. Baseline tail-flick latencies were obtained before injecting vehicle or ω-agatoxin IVA (0.063–0.48 μm) mixed with 0.12% bupivacaine. Local anesthesia was tested 30 min later. (B ) ω-Conotoxin MVIIC did not affect bupivacaine anesthesia. Baseline tail-flick latencies were obtained before injecting vehicle or ω-conotoxin MVIIC (3.64–72.8 μm) mixed with 0.12% bupivacaine. The mice were tested for local anesthesia 30 min later. %MPE = percentage of maximum possible effect.