Fig. 3. Effect of glibenclamide (1 μm) treatment and endothelial removal with the nonionic detergent CHAPS (0.4%) on arteriolar responses to increasing concentrations of sodium nitroprusside. Neither glibenclamide nor endothelial denudation affected the dose response of vessels to sodium nitroprusside. Baseline ID in control vessels was 76 ± 3 μm and was not affected by either treatment. Vertical bars represent 1 ± SEM.