Fig. 1. Effects of propofol on the adenosine triphosphate–sensitive potassium (K^ATP) channel activities in the cell-attached configuration. Membrane potentials were clamped at −50 mV. Propofol concentrations presented are the actual concentrations measured in the current study. (A ) Representative example of the effects of 25 μm 2,4-dinitrophenol (DNP) alone or in combination with propofol on K^ATPcurrents. The periods of drug treatment are marked with horizontal bars. Propofol attenuated 2,4-dinitrophenol–induced K^ATPcurrents in a concentration-dependent manner. (B ) Concentration-dependent effects of propofol on 2,4-dinitrophenol–induced K^ATPchannel activities. Each vertical bar constitutes measurements from 15–20 patches (mean ± SD). *P < 0.05 versus  baseline (2,4-dinitrophenol alone).