Fig. 4. Effects of propofol on diazoxide (25 μm)-induced flavoprotein oxidation. Propofol concentrations presented are the actual concentrations measured in the current study. (A ) Representative example of the effects of diazoxide alone or in combination with propofol on flavoprotein fluorescence. The periods of drug treatment are marked with horizontal bars. Propofol attenuated diazoxide-induced flavoprotein oxidation in a concentration-dependent manner. The redox signal was normalized to the fluorescence value obtained with 5 μm of 2,4-dinitrophenol (DNP) at the end of experiments. (B ) Concentration-dependent effects of propofol on diazoxide-induced flavoprotein oxidation. Each vertical bar constitutes measurements from 12 single ventricular myocytes (mean ± SD). *P < 0.05 versus  diazoxide alone.