Table 1. Trial Designs and Target Concentrations Chosen

In all cases target concentrations were calculated so that 96–97% of the E^maxconcentration using the combination would be attained.

* Higher concentrations of drug, above its C⁵⁰, were not explored because pilot testing demonstrated that the hysteresis loop between concentration and effect for the other drug could not be reliably collapsed using the type of data in this study.