Table 4. Pharmacodynamic Parameters, Interaction Terms, and Weighted Residuals for the Median and Worst Fits Using Each Model Design

Median and worst fits were chosen based on their ability to recapture the original model by the criteria of achieving the lowest possible MDARSE, using trials of 20 patients.

MDWR = median weighted residual; MDAWR = median absolute weighted residual; MDRSE = median residual surface error; MDARSE = median absolute residual surface error.